geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Cardiovascular effects of basal insulins


, : Cardiovascular effects of basal insulins. Drug, Healthcare and Patient Safety 7: 113-120

Basal insulin is an important component of treatment for both type 1 and type 2 diabetes. One of the principal aims of treatment in patients with diabetes is the prevention of diabetic complications, including cardiovascular disease. There is some evidence, although controversial, that attainment of good glycemic control reduces long-term cardiovascular risk in both type 1 and type 2 diabetes. The aim of this review is to provide an overview of the potential cardiovascular safety of the different available preparations of basal insulin. Current basal insulin (neutral protamine Hagedorn [NPH], or isophane) and basal insulin analogs (glargine, detemir, and the more recent degludec) differ essentially by various measures of pharmacokinetic and pharmacodynamic effects in the bloodstream, presence and persistence of peak action, and within-subject variability in the glucose-lowering response. The currently available data show that basal insulin analogs have a lower risk of hypoglycemia than NPH human insulin, in both type 1 and type 2 diabetes, then excluding additional harmful effects on the cardiovascular system mediated by activation of the adrenergic system. Given that no biological rationale for a possible difference in cardiovascular effect of basal insulins has been proposed so far, available meta-analyses of publicly disclosed randomized controlled trials do not show any signal of increased risk of major cardiovascular events between the different basal insulin analogs. However, the number of available cardiovascular events in these trials is very small, preventing any clear-cut conclusion. The results of an ongoing clinical trial comparing glargine and degludec with regard to cardiovascular safety will provide definitive evidence.

US$19.90

PMID: 26203281

DOI: 10.2147/DHPS.S43300


Other references

Fuhrmann, O., 1913: Die Atmungsorgane von Typhlonectes. Zoologischer Anzeiger Leipzig, 42 229-234

Obraztsov V.V.; Selishcheva A.A.; Danilov V.S., 1975: Study of the rate of interaction of ferri cytochrome c with negatively charged liposomes of natural lecithin effect of the physicochemical state of the membrane hydrophobic layer. Biophysics (English Translation of Biofizika) 20(6): 1052-1057

Mowszowicz J., 1968: Relations between plant phylogeny and phytochemistry. Kosmos Seria A Biologia (Warsaw) 17(1): 17-22

Beveridge, I.; Turni, C., 2003: Progamotaenia capricorniensis sp nov from wallabies from Queensland, Australia. Progamotaenia capricorniensis sp. nov. (Cestoda: Anoplocephalidae) is described from the wallabies Macropus dorsalis (Gray, 1837) and Petrogale assimilis Ramsay, 1877 from Queensland, Australia. The new species is characterised by a fimbriated vel...

Wiklund, L.; Mcgregor, C.G.A.; Miller, V.M., 1994: Effects of antioxidants on endothelium-dependent relaxations in pulmonary arteries following long-term exposure of oxygen-derived free radicals. Clinical Research 42(2): 325A

Newton, Stephen F. al Suhaibani, Abdullah H., 1996: Survey of summer breeding seabirds in the Saudi Arabian Red Sea. Phoenix. December; 13: 5-6

Fitzgerald, S.D.; Alstine, W. van, 1990: Diagnosing the underlying cause of end-stage kidney disease in a Shar Pei puppy. A PM examination was made on a 19 week old Shar Pei bitch puppy with a history of tracheobronchitis, pruritic pustular dermatitis, polyuria, polydipsia and convulsions. 3 of 6 littermates died within 38 h of birth. The puppy had azotemia, indicati...

Out, Dée.; Bakermans-Kranenburg, M.J.; Granger, D.A.; Cobbaert, C.M.; van Ijzendoorn, M.H., 2012: State and trait variance in salivary α-amylase: a behavioral genetic study. This is the first behavior genetic study of salivary α-amylase (sAA), focusing on genetic and environmental influences on stability and change in sAA during baseline and exposure to infant crying. The sample consisted of 184 adult twin pairs. Alt...

Henn, M.W.; Schopf, R., 2001: Response of beech to elevated CO2 and N Influence on larval performance of the gypsy moth Lymantria dispar. Two-year-old beech seedlings were kept from germination to bioassays with Lymantria dispar under the following conditions: ambient CO2/low N, elevated CO2/low N, ambient CO2/elevated N, and elevated CO2/elevated N. The effect of these growing cond...

Pastor-Galan, D.; Gutierrez-Alonso, G., 2010: Syn-orocline brittle deformation in the core of the Ibero-Armorican Arc; timing orocline formation. Geophysical Research Abstracts 12