geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Cerebral Blood Flow Alterations as Assessed by 3D ASL in Cognitive Impairment in Patients with Subcortical Vascular Cognitive Impairment: A Marker for Disease Severity


, : Cerebral Blood Flow Alterations as Assessed by 3D ASL in Cognitive Impairment in Patients with Subcortical Vascular Cognitive Impairment: A Marker for Disease Severity. Frontiers in Aging Neuroscience 8: 211-211

Abnormal reductions in cortical cerebral blood flow (CBF) have been identified in subcortical vascular cognitive impairment (SVCI). However, little is known about the pattern of CBF reduction in relation with the degree of cognitive impairment. CBF measured with three-dimensional (3D) Arterial Spin Labeling (ASL) perfusion magnetic resonance imaging (MRI) helps detect functional changes in subjects with SVCI. We aimed to compare CBF maps in subcortical ischemic vascular disease (SIVD) subjects with and without cognitive impairment and to detect the relationship of the regions of CBF reduction in the brain with the degree of cognitive impairment according to the z-score. A total of 53 subjects with SVCI and 23 matched SIVD subjects without cognitive impairment (controls), underwent a whole-brain 3D ASL MRI in the resting state. Regional CBF (rCBF) was compared voxel wise by using an analysis of variance design in a statistical parametric mapping program, with patient age and sex as covariates. Correlations were calculated between the rCBF value in the whole brain and the z-score in the 53 subjects with SVCI. Compared with the control subjects, SVCI group demonstrated diffuse decreased CBF in the brain. Significant positive correlations were determined in the rCBF values in the left hippocampus, left superior temporal pole gyrus, right superior frontal orbital lobe, right medial frontal orbital lobe, right middle temporal lobe, left thalamus and right insula with the z-scores in SVCI group. The noninvasively quantified resting CBF demonstrated altered CBF distributions in the SVCI brain. The deficit brain perfusions in the temporal and frontal lobe, hippocampus, thalamus and insula was related to the degree of cognitive impairment. Its relationship to cognition indicates the clinical relevance of this functional marker. Thus, our results provide further evidence for the mechanisms underlying the cognitive deficit in patients with SVCI.

US$19.90

PMID: 27630562

DOI: 10.3389/fnagi.2016.00211


Other references

Wilson, R.C.; Cooper, J.B., 1994: Characterization of PRP1 and PRP2 from Medicago truncatula. Plant Physiology 105(1): 445-446

Evans, M.J.; Kovacs, C.J., 1994: Cytokine-induced accelerated recovery of myelosuppressed murine bone marrow is mediated through the high proliferative potential-1 colony forming cell. Proceedings of the American Association for Cancer Research Annual Meeting 35(0): 523

Molina, R.; Allred, G.; Tandom, A.; Fuqua, S.; Chamness, G.; Clark, G.; Mcguire, W.L., 1992: PS2 expression in node-positive breast cancer patients. Anticancer Research 12(6A): 1908

Griffith, G.L.; Mattingly, W.T.; Tood, E.P., 1981: Current diagnosis and management of blunt thoracic aortic trauma. Journal of the Kentucky Medical Association 79(9): 588-593

Slusarz, M.J., 2012: Molecular modeling study of the opioid receptor interactions with series of cyclic deltorphin analogues. In this study, ten tetra- and heptapeptide analogues of deltorphin containing the urea bridges between residues 2 and 4 have been docked into the δ- and µ-opioid receptors to explain their different biological activities. The important factors e...

Kahn, A., 1985: Weight losers and gainers on seemingly identical diets. Journal of the Arkansas Medical Society 82(3): 158-159

Benlloch, M., 1940: Dust Insecticides. The author briefly discusses the advantages and disadvantages of dust insecticides as compared with sprays. Dusts are not generally employed in Spain, the main reason being that the quantity of insecticide needed is greater than with a spray, but...

Anonymous, 1987: Proceedings of the Sixth Entomological Congress organized by the Entomological Society of Southern Africa. Stellenbosch, 6-9 July, 1987. Abstracts are presented of over 100 papers, posters and workshops that were presented at the Sixth Entomological Congress of the Entomological Society of Southern Africa, held at Stellenbosch in July 1987. Most contributions related to the biology...

Steward, J.A.; White, C.; Reynolds, S., 2008: Leukaemia incidence in Welsh children linked with low level radiation--making sense of some erroneous results published in the media. A series of self-published epidemiological reports purporting to show a major excess risk of leukaemia in pre-school children living near the Irish Sea coast of Wales have been presented in the media as evidence of the harmful effects of low leve...

Ghosh, S.; Sahoo, T.; Adhikari, S.; Sharma, R.; Varandas, Aónio.J.C., 2015: Coupled 3D Time-Dependent Wave-Packet Approach in Hyperspherical Coordinates: The D(+)+H2 Reaction on the Triple-Sheeted DMBE Potential Energy Surface. We implement a coupled three-dimensional (3D) time-dependent wave packet formalism for the 4D reactive scattering problem in hyperspherical coordinates on the accurate double many body expansion (DMBE) potential energy surface (PES) for the ground...