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Changes in apoptotic factors and caspase activation pathways during the postmortem aging of beef muscle

, : Changes in apoptotic factors and caspase activation pathways during the postmortem aging of beef muscle. Food Chemistry 190: 110-114

The pathway of apoptosis (effector caspase activation) in beef muscle cells was investigated by examining the expression of apoptotic factors during postmortem (PM) storage of beef muscle. Results showed that caspase-3 could be activated in PM beef muscle. The expression of cytochrome c increased in the cytosolic fraction but significantly decreased in the mitochondrial fraction in the early PM period, which demonstrated that cytochrome c was released from mitochondrion to cytoplasm. The expression of the anti-apoptotic factor Bcl-2 did not show any visible change, and that of pro-apoptotic factor Bax increased during PM storage. Expression of the heat-shock protein Hsp27 significantly decreased with increased PM time. These results demonstrated that the mitochondrial pathway was one of the apoptosis pathways in PM beef muscle and that Bax and Hsp27 were two key regulation factors in apoptosis in PM beef muscle.


PMID: 26212948

DOI: 10.1016/j.foodchem.2015.05.056

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Hiller, N.Luisa.; Chauhan, A.; Palmer, M.; Jain, S.; Sotereanos, N.G.; Altman, G.T.; Nistico, L.; Kreft, R.; Post, J.Christopher.; Demeo, P.J., 2015: Presence of bacteria in failed anterior cruciate ligament reconstructions. Novel microbial detection technologies have revealed that chronic bacterial biofilms, which are recalcitrant to antibiotic treatment, are common in failed orthopedic procedures. Are bacteria present on failed anterior cruciate ligament (ACL) recon...

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Vernaglione, E., 1961: Considerations on the antalgic treatment of painful syndromes due to neoplasms in pelvic site. Minerva Anestesiologica 27: 84-87

Mason, D.Y., 1975: Measurement of kappa:lambda light chain ratios by haemagglutination techniques. Haemagglutination techniques are described for quantitating kappa:lambda ratios in human immunoglobulin. The techniques have been evaluated using monoclonal light chains from myeloma patients, but are applicable to a variety of clinical situations...

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