geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Ciprofloxacin-loaded keratin hydrogels reduce infection and support healing in a porcine partial-thickness thermal burn


, : Ciprofloxacin-loaded keratin hydrogels reduce infection and support healing in a porcine partial-thickness thermal burn. Wound Repair and Regeneration 24(4): 657-668

Infection is a leading cause of morbidity and mortality in burn patients. Current therapies include silver-based creams and dressings, which display limited antimicrobial effectiveness and impair healing. The need exists for a topical, point-of-injury antibiotic treatment that provides sustained antimicrobial activity without impeding wound repair. Fitting this description are keratin-based hydrogels, which are fully biocompatible and support the slow-release of antibiotics. Here we develop a porcine model of an infected partial-thickness burn to test the effects of ciprofloxacin-loaded keratin hydrogels on infection and wound healing. Partial-thickness burns were inoculated with either Pseudomonas aeruginosa or Methicillin-resistant Staphylococcus aureus, resulting in infections that persisted for >2 weeks that exceeded 10(5) and 10(6) cfu per gram of tissue, respectively. Compared to silver sulfadiazine, ciprofloxacin-loaded keratin hydrogel treatment significantly reduced the amount of P. aeruginosa and S. aureus in the burn by >99% on days 4, 7, 11, and 15 postinjury. Further, burns treated with ciprofloxacin-loaded keratin hydrogels exhibited similar healing patterns as uninfected burns with regards to reepithelialization, macrophage recruitment, and collagen deposition and remodeling. The ability of keratin hydrogels to deliver antibiotics to fight infection and support healing of partial-thickness burns make them a strong candidate as a first-line burn therapy.

US$19.90

PMID: 27238250

DOI: 10.1111/wrr.12449


Other references

Claesson, A.; Asell, A.; Bjorkman, S.; Olsson, L.I., 1978: An allenic oxo tremorine analog. The synthesis of 1-[5-(1-pyrrolidinyl)-2,3-pentadienyl]-2-pyrrolidone from 1-(2-propynyl)-2-pyrrolidone in 2 steps is described. Alternative routes via organocuprate reactions failed. The allene was tested for oxotremorine agonism-antagonism in mi...

Richiardi, P.; Crepaldi, T.; Malavasi, F.; Carbonara, A.O., 1984: Contribution of monoclonal antibodies to the study of HLA class I antigens. La Ricerca in Clinica E in Laboratorio 14(3): 287-295

Todt, H.; Wünsche, W.; Korth, G., 1976: Results of Fali-lepsin therapy of cerebral convulsions in childhood. Kinderarztliche Praxis 44(4): 156-160

Sabljic, A.; Gusten, H., 1990: Predicting the night-time NO3 radical reactivity in the troposphere. A statistically significant linear correlation between the reaction rate constant, kN, for the NO3 free radical reaction with 69 organic compounds in the gas phase at 298 K and the corresponding vertical ionization energies, Ei,v, allows an a prio...

Lee, T.H., 1999: Ask the doctor. I have tried - and stopped - almost every medication known to man for treatment of high blood pressure. All of them have caused a serious side effect, impotence. Is there any medication out there or coming soon that can control blood pressure without causing impotence?. Harvard Heart Letter 9(11): 8-8

Cornelison, D.M.; Dillingham, T.R., 1997: Scanning tunneling microscopy and tunneling spectroscopy on vapor-deposited polythiophene. Scanning 19(3): 228-229

Meyers J.H.; Schwartz R.K.; DeCelles Peter G.; Suttner L.J., 1989: Jurassic and Cretaceous intraforeland tectonic events and sedimentation, southwestern Montana. Abstracts with Programs - Geological Society of America 21(5): 117

Luo, Y-ming.; Chen, R-chang.; Zhong, N-shan., 2005: Measurement of diaphragm compound muscle action potential with magnetic stimulation of the phrenic nerve and multipara esophageal electrode in intensive care unit. To investigate whether magnetic stimulation of the phrenic nerve and multipara esophageal electrode can be used to measure diaphragm compound muscle action potential (CMAP) in intensive care unit (ICU). Ten normal subjects and 10 patients in ICU w...

Peil, J.; Schmerling, S., 1986: Case studies of the use of the locally adjusted polynomial regression. Firstly the operation mode of the procedures of local adjusted polynomial regression is explained by an artificial example of data. After that, the properties of these nonparametric estimation procedures of unknown continuous functions from measur...

Rose, J.B.; Galinkin, J.L.; Jantzen, E.C.; Chiavacci, R.M., 2002: A study of lidocaine iontophoresis for pediatric venipuncture. In this randomized, double-blinded, placebo-controlled study, we evaluated the safety and efficacy of lidocaine iontophoresis for the prevention of pain associated with venipuncture in 59 children aged 6-17 yr. Children received either lidocaine H...