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Classification of microvascular patterns via cluster analysis reveals their prognostic significance in glioblastoma


, : Classification of microvascular patterns via cluster analysis reveals their prognostic significance in glioblastoma. Human Pathology 46(1): 120-128

There are limited researches focusing on microvascular patterns (MVPs) in human glioblastoma and their prognostic impact. We evaluated MVPs of 78 glioblastomas by CD34/periodic acid-Schiff dual staining and by cluster analysis of the percentage of microvascular area for distinct microvascular formations. The distribution of 5 types of basic microvascular formations, that is, microvascular sprouting (MS), vascular cluster (VC), vascular garland (VG), glomeruloid vascular proliferation (GVP), and vasculogenic mimicry (VM), was variable. Accordingly, cluster analysis classified MVPs into 2 types: type I MVP displayed prominent MSs and VCs, whereas type II MVP had numerous VGs, GVPs, and VMs. By analyzing the proportion of microvascular area for each type of formation, we determined that glioblastomas with few MSs and VCs had many GVPs and VMs, and vice versa. VG seemed to be a transitional type of formation. In case of type I MVP, expression of Ki-67 and p53 but not MGMT was significantly higher as compared with those of type II MVP (P < .05). Survival analysis showed that the type of MVPs presented as an independent prognostic factor of progression-free survival (PFS) and overall survival (OS) (both P < .001). Type II MVP had a more negative influence on PFS and OS than did type I MVP. We conclude that the heterogeneous MVPs in glioblastoma can be categorized properly by certain histopathologic and statistical analyses and may influence clinical outcome.

US$19.90

PMID: 25455996

DOI: 10.1016/j.humpath.2014.10.002


Other references

Choi, J.; Park, H.; Lee, C-Hyun., 2016: Analysis of a blog for gastrointestinal disease in the view point of the big data: a single institutional study. With the enormous increase in the amount of data, the concept of big data has emerged and this allows us to gain new insights and appreciate its value. However, analysis related to gastrointestinal diseases in the viewpoint of the big data has not...

Agacino, E.Morales, 1936: Descripcion de un Antaxius nuevo de Francia. A. chopardi* (p.49); key to separate 4 spp. of Antaxius.

Mori, J.; Nagai, S.; Sakakibara, J.; Takeya, K.; Hotta, Y.; Ando, H., 1987: Studies on cardiac ingredients of plants. III. Structural confirmation and biological activity of reduced proscillaridins. Catalytic hydrogenation of proscillaridin (I) gave five compounds (II-VI) which were successfully separated by reversed-phase high performance liquid chromatography. The structures of II-VI were determined on the basis of the proton, carbon-13 and...

Hagen, S.; Kolbenstvendt, A.; Host, H., 1971: Pulmonary changes after postoperative 60cobalt-treatment of breast neoplasms. Nordisk Medicin 85(22): 707-707

Matsukawa, S.; Mawatari, K.; Yoneyama, Y., 1987: Structure and function relationship of abnormal hemoglobins with disturbed oxygen binding functions. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme 32(6): 635-642

Austin, D., F.; Tapia-Munoz, J.-Luis, 2001: Ipomoea sororia (Convolvulaceae), a new species from Yucatan, Mexico. Ipomoea sororia, a new species in Ipomoea section Leptocallis is described from the Yucatan Peninsula of Mexico. This species, apparently endemic to a small region of low deciduous forest in the NW of the peninsula, is similar to the more widespre...

Lad, P.M.; Lin, C.K.w E.; Chen, F.S.an; Nguyen, T.T.uan; Kalunta, C.I.; Yang, C.L.nzhi; Kaptein, J.S., 1994: Differential effects of anti-Ig and IFN-alpha on growth and apoptosis in EBV-positive Daudi and EBV-negative Ramos Burkitts lymphoma cell lines. Journal of Leukocyte Biology 0(SUPPL ): 36

Folnegović, Z.; Folnegović-Smalc, V.; Kulcar, Z., 1990: Characteristics of male and female schizophrenics at first admission. Based on information from a case register, patient age and diagnosis at first admission are analysed in a Croatian cohort of schizophrenics first admitted in 1972 and followed up through the register for 12 years. Diagnosis was analysed on the sam...

Van Hook, K.; Huang, T.; Alumkal, J.J., 2014: Orteronel for the treatment of prostate cancer. Orteronel (also known as TAK-700) is a novel hormonal therapy that is currently in testing for the treatment of prostate cancer. Orteronel inhibits the 17,20 lyase activity of the enzyme CYP17A1, which is important for androgen synthesis in the te...

Zottoli R., 1983: Amphisamytha galapagensis new species of ampharetid polychaete from the vicinity of abyssal hydro thermal vents in the galapagos rift pacific ocean and the role of this species in rift ecosystems. A. galapagensis, a new polychaete species of the family Ampharetidae, is described from hydrothermal vents of the Galapagos Rift. The placement of A. galapagensis in the genus Amphisamytha and its relationship with the other 2 spp. [A. japonica an...