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Clinical experiences and success rates of acromegaly treatment: the single center results of 62 patients

, : Clinical experiences and success rates of acromegaly treatment: the single center results of 62 patients. Bmc Endocrine Disorders 14(): 97-97

This study aimed to report the clinical and outcome data from a large cohort of patients diagnosed with acromegaly and treated at our institution over a 20-year period. Sixty-two acromegaly patients (32 women and 30 men) treated and monitored at the endocrinology polyclinic between 1984 and 2013 were enrolled in this retrospective study. Clinical features and patients' treatment outcomes were evaluated. A level of growth hormone (GH) of <2.5 ng/ml was considered as the criterion for remission, and the normal insulin-like growth factor (IGF) range was based on gender and age. The mean age at the time of diagnosis was 38.8 ± 1.4 years, the time to diagnosis was 4.5 ± 0.3 years, and the follow-up duration was 7.3 ± 0.8 years. Among patients' symptoms, growth in hands and feet and typical facial dysmorphism were the most prominent (92%). The number of patients with diabetes mellitus, hypertension and hyperprolactinemia were 22 (35%), 13 (21%) and 13 (21%), respectively. Microadenomas and macroadenomas were found in eight and 54 patients, respectively. A significant correlation was found between the initial tumor diameters and GH levels (p = 0.002). The mean GH and IGF-1 levels were 39.18 ± 6.1 ng/ml and 993.5 ± 79 ng/ml, respectively. Visual field defect was found in 16 patients (32%). Thirty-one patients were treated by transsphenoidal surgery. Four of these were cured, 10 patients developed postoperative anterior pituitary hormone deficiency, and one patient developed diabetes insipidus. Twenty patients were treated by transcranial surgery, of which two were cured, while 17 patients developed postoperative anterior pituitary hormone deficiency. In total, five of the patients who were not cured after surgery were given conventional radiotherapy, of which two were cured. Four of 15 patients, on whom Gamma Knife radiosurgery was performed, were cured. Biochemical remission was achieved in 32 of 52 patients who received octreotide treatment, and in two of five patients who received lanreotide treatment. The rate of surgical success in our patients was found to be low. This could be explained by an absence of experienced pituitary surgical centers or surgeons in our region, and the fact that most patients presented late at the macroadenoma stage.


PMID: 25511633

DOI: 10.1186/1472-6823-14-97

Other references

Torres, R.; de la Piedra, C.; Rapado, A., 1991: Clinical usefulness of serum tartrate-resistant acid phosphatase in Paget's disease of bone: correlation with other biochemical markers of bone remodelling. Tartrate resistant acid phosphatase (TRAP) has been proposed as a new biochemical marker for bone resorption. We have compared this new marker, TRAP, with the classical biochemical markers of bone remodelling, serum alkaline phosphatase (sAP), ser...

Van-Der-Schyff, J.; Theron, P.D.; Ueckermann, E.A., 2005: Descriptions of seven new species of the genus Bdella Latreille (Acari: Prostigmata: Bdellidae) from southern Africa and a redescription of B. neograndjeani Meyer & Ryke. Seven new southern African species in the family Bdellidae, namely Bdella aloios, B. nylsvleyensis, B. malawiensis, B. boskopensis, B. carolae, B. vates and B. consobrinae, are described and illustrated and B. neograndjeani Meyer & Ryke is redescr...

Collins, N.J.; Vicenzino, B.; van der Heijden, R.A.; van Middelkoop, M., 2016: Pain During Prolonged Sitting Is a Common Problem in Persons With Patellofemoral Pain. Study Design Retrospective cohort. Background Although persons with patellofemoral pain (PFP) often report pain with prolonged sitting, little is known about the prevalence and characteristics of sitting pain. Objectives To describe the proportion...

Pyl, G., 1953: A concentrated adsorbate vaccine against foot and mouth disease prepared from purified antigen. From experiments in cattle and pigs it was concluded that the normal vaccinating dose could be reduced to about one-fiftieth by carrying out a preliminary concentration of the antigen in the original unfiltered tissue suspension. This was done by...

Reich, T.; Schmidt, S.; Fortnagel, P., 1999: Metabolism of phenylbenzoate by Pseudomonas sp. strain TR3. A bacterial isolate, tentatively identified as Pseudomonas sp. strain TR3, was found to utilize the diaryl ester phenylbenzoate as sole source of carbon and energy. This strain has the ability to productively degrade phenylbenzoate and some substi...

Wiecko, E., 1975: The world forest resources economy with special reference to the socialist countries. Przeglad geograficzny Polish geographical review: 7 (1) 35-61

Uberall, M.A., 2014: Use of strong opioids in general practice. Mmw Fortschritte der Medizin 155 Spec No 2: 62-7; Quiz 68

Anonymous, 1998: Solicitation of information and recommendations for developing OIG compliance program guidance for certain Medicare+Choice organizations--OIG, HHS. Correction. Federal Register 63(190): 52799-52799

Holmes, J.A.; Stevenson, C.A., 1990: Differential effects of avoidant and attentional coping strategies on adaptation to chronic and recent-onset pain. Examined the effectiveness of attentional and avoidant coping strategies for somatic, behavioral, and psychological adaptation to clinical pain. Subjects were 30 chronic and 30 recent-onset pain patients who used either attentional or avoidant cop...

Wolff, M.; Vogel, W.; Safronov, B., V., 1998: Uneven distribution of K+ channels in soma, axon and dendrites of rat spinal neurones: Functional role of the soma in generation of action potentials. 1. A novel method of 'entire soma isolation' was used to describe the distribution of voltage-gated K+ channels between soma, axon and dendrites of dorsal horn neurones identified in spinal cord slices of newborn rat. 2. The soma contain...