+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Clinical outcomes of adult inpatients treated with continuous subcutaneous insulin infusion for diabetes mellitus: a systematic review

, : Clinical outcomes of adult inpatients treated with continuous subcutaneous insulin infusion for diabetes mellitus: a systematic review. Diabetic Medicine 32(10): 1279-1288

To provide a systematic review of the current evidence concerning the diabetes-related outcomes of patients provided with continuous subcutaneous insulin infusion for treating diabetes mellitus while a hospital inpatient. Relevant publications were obtained from MEDLINE and EMBASE databases concerning hospital inpatients with diabetes being treated with continuous subcutaneous insulin infusion. Studies were assessed independently by two reviewers, and data on the following outcomes were extracted: inpatient mortality; clinical complications, e.g. diabetic ketoacidosis; hyperglycaemia; hypoglycaemia; length of hospital stay; mean bedside glucose level; and glucose level on discharge. Obstetric cases were examined separately to look at maternal and neonatal glycaemic outcomes. A total of 11 studies met the required criteria and were analysed in detail, 5 of which were predominantly obstetric. No significant complications were reported, with no incidences of death, ketoacidosis or severe hypoglycaemia. Length of hospital stay appeared to be shorter in those patients who remained on continuous subcutaneous insulin infusion, while data on mild hyperglycaemia and hypoglycaemia were inconclusive. There are limited data available to form a significant conclusion about the safety of continuous subcutaneous insulin infusion continuation in hospital; however, its use can be justified with the presence of a specialized inpatient diabetes team for advice and support and an alternative treatment regime (e.g. subcutaneous basal bolus) should be accessible if the need were to arise.


PMID: 25763540

DOI: 10.1111/dme.12740

Other references

Wang, Z.; Hu, P.; Tang, F.; Lian, H.; Chen, X.; Zhang, Y.; He, X.; Liu, W.; Xie, C., 2016: HDAC6 promotes cell proliferation and confers resistance to temozolomide in glioblastoma. Histone deacetylases are considered to be among the most promising targets in drug development for cancer therapy. Histone deacetylase 6 (HDAC6) is a unique cytoplasmic enzyme that regulates many biological processes involved in tumorigenesis thro...

Doreau M.; Michalet Doreau B., 1988: In sacco degradability of feed dry matter and cell walls in the rumen influence of fat content in diets fed to dairy cows. Reproduction Nutrition Developpement 28(1): 157-158

Evans, S., 1977: Competitive relationships between cotton and other crops, by region, 1976 and 1977. Breakeven prices of cotton in the four major producing regions are calculated for 1976 and early 1977. the breakeven prices are compared with cotton farm prices to determine the direction of acreage adjustments in the regions.

Krauze, Nĭ.Ieronimovich., 2005: Nikalaj Ieronimovich Krauze (1887-1950). Vestnik Khirurgii Imeni I. I. Grekova 163(4): 92-93

Lorin, M.I., 1982: Outpatient identification of children with bacteremia. Journal of Pediatrics 100(3): 510-511

Mcconachie I.; Healy T.E.J., 1989: Ace inhibitors and anesthesia. Postgraduate Medical Journal 65(763): 273-274

Hösgör, M.; Ijzendoorn, Y.; Mooi, W.J.; Tibboel, D.; D.K.ijger, R.R., 2002: Thyroid transcription factor-1 expression during normal human lung development and in patients with congenital diaphragmatic hernia. Thyroid transcription factor-1 (TTF-1) was detected in human respiratory epithelial cells from 11 weeks of gestation. TTF-1 is involved in both lung morphogenesis and in the regulation of surfactant proteins. Recently, low expression of TTF-1 in t...

Weseloh, RM., 1988: Host recognition by the gypsy moth (Lymantria dispar) (Lep.: Lymantriidae) hyperparasite, Eurytoma appendigaster (Hym.: Eurytomidae) of cocoons of Cotesia melanoscela (Hym.: Braconidae). The host recognition behaviour of the Lymantria dispar hyperparasitoid, Eurytoma appendigaster, towards its primary host, Cotesia melanoscela [Apanteles melanoscelus], was investigated in the laboratory. A variety of natural, modified and artifici...

M. van der Spiegel; H.J. van der Fels-Klerx; H.J.P.M.rvin, 2012: Effects of climate change on food safety hazards in the dairy production chain. The aim of this study is to analyse the effect of climate change on emerging food safety hazards in the dairy production chain. For this purpose, a holistic approach was used to select critical factors from inside and outside the production chain...

Liskow B.; Powell B.J.; Nickel E.J.; Penick E., 1990: Diagnostic subgroups of antisocial alcoholics outcome at 1 year. Of 233 alcoholics initially evaluated and subdivided into groups with an additional diagnosis of antisocial personality disorder (ASP) only (N = 38), ASP plus drug abuse (N = 30), ASP plus major depressive disorder (N = 18), and those with no addi...