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Clinical significance of urothelial carcinoma associated 1 in colon cancer

, : Clinical significance of urothelial carcinoma associated 1 in colon cancer. International Journal of Clinical and Experimental Medicine 8(11): 21854-21860

This study aimed to investigate the expression levels of urothelial carcinoma associated 1 (UCA1) in cancer tissues and plasma of colon cancer patients, and evaluate its clinical significance. Quantitative real-time PCR was used to determine the expression levels of UCA1 in 80 pairs of colon cancer and adjacent normal tissues, plasma samples from 20 healthy controls, 20 colon cancer patients before and after tumor removal. The relationships between UCA1 expression and clinical features and overall survival were analyzed. Compared with adjacent normal tissues, UCA1 was significantly upregulated in colon cancer tissues, especially in cases with LNM and advanced TNM stages (P < 0.05). High UCA1 expression was associated with LMN, higher pT category, and advanced TNM stages (P < 0.05). Patients with high UCA1 expression had worse survival time than those with low UCA1 expression (adjusted HR = 2.002, 95% CI 1.007-3.981, P = 0.048). Furthermore, plasma levels of UCA1 in colon cancer patients were significantly higher than those of controls (P = 0.016). There was significant difference in plasma level of UCA1 between samples taken before and after surgery (P = 0.048). In conclusion, tissue expression of UCA1 is related to prognosis in colon cancer. Plasma UCA1 may serve as a potential biomarker for early diagnosis and disease monitoring of colon cancer patients.


PMID: 26885155

Other references

Nurunnaher ; Rahman, K.M.; Ali, M.H., 2003: Productivity and efficiency measurement of rice production by member and non-member farmers in selected cooperative societies of Bangladesh. This study was conducted to investigate the impact of institutional credit on rice (cv. boro, aus, aman) production, investment and income of the member and non-member farmers in selected cooperatives in Bangladesh during 2001-02. It was found tha...

Finkel'shteĭn, S.I., 1985: Intraosseous nodes (ganglia). Vestnik Rentgenologii i Radiologii: 52-55

Nelson A.E. (investigator), 1979: Thrust plates in the Blue Ridge. U S

Plattner, H.; Schneider, E., 1969: Beitrag zur Verbreitung der Lederwanzen Heteroptera, Coreidae in Rumanien. Nachrichtenblatt der Bayerischen Entomologen, 18(1): 7-13

Ubaldi, A.; Gobbi, L.; Quintavalla, F., 1986: Clinical safety of a lincomycin spectinomycin combination in dairy cows. Spectinomycin at 10 mg/kg and lincomycin at 5 mg/kg were given in daily i/m injections for 4 consecutive days to 4 cows, and the same antibiotics at 30 mg/kg and 15 mg/kg, respectively, were given i/m for 3 consecutive days to another 4 cows. Ther...

Arshad, M.P.ulsson, M.D.jmek, P., 1993: Rheology of buildup, breakdown, and rebodying of acid casein gels. Dynamic oscillations were measured during in situ buildup and breakdown of acid casein gels induced by glucono-delta-lactone at varying temperatures and skim milk solids concentrations. The gel structure was gradually broken down by continuous osc...

Hirszfeld, L.; Zborowsi, H., 1926: The principles of the serological relations of mother and embryo. Klin Wochenschr 5(17): 741-744

Huma, P.O., 1990: A comparison of diprivan and thiopentone when used as induction agents for short surgical procedures. Anaesthetic properties of Diprivan and thiopentone as intravenous induction agents were compared on patients presenting for short surgical or investigative procedures at the Kenyatta National Hospital, Nairobi, Kenya. Each group of the comparative...

Fortic, B., 1965: Possibilities and results of surgical therapy in bronchial carcinoma. (3-year results in 201 cases). Tuberkuloza 17(1): 135-149

Walls R.A.; Harris W.B.rleigh; Nunan W.E., 1973: Subaerial diagenesis; Carboniferous carbonate mud banks, northeastern Kentucky. Abstracts with Programs Geological Society of America: Pages 448-449. 1973.