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Co-assembly of doxorubicin and curcumin targeted micelles for synergistic delivery and improving anti-tumor efficacy


, : Co-assembly of doxorubicin and curcumin targeted micelles for synergistic delivery and improving anti-tumor efficacy. European Journal of Pharmaceutics and Biopharmaceutics

NlmCategory="UNASSIGNED">Chemotherapeutic drugs have a series of limitations in anti-tumor treatment, mainly including multidrug resistance (MDR) and serious adverse reactions. Co-delivery system with two or more synergistic therapeutic drugs is an effective strategy to settle these limitations. In this study, active tumor-targeted co-delivery micelles (DOX+Cur)-PMs, with two synergistic drugs of a therapeutic drug of doxorubicin (DOX) and a chemosensitizer of curcumin (Cur) co-encapsulated into hyaluronic acid-vitamin E succinate (HA-VES) graft copolymer, were prepared and delivered simultaneously into tumor cells for improving therapeutic effects of DOX. (DOX+Cur)-PMs had uniform particle size, high encapsulation efficacy, sustained release profile and good colloidal stability. In vitro cytotoxicity study, (DOX+Cur)-PMs exerted the strongest cytotoxicity and highest cell apoptosis-inducing activities against DOX-resistant MCF-7/Adr cells. Moreover, (DOX+Cur)-PMs more efficiently internalized into cancer cells and enhanced the cellular uptake of DOX via energy-dependent and caveolae-mediated endocytosis, and significantly reversed MDR effects via CD44 targeting delivery and the synergic effect of released Cur. More importantly, in vivo results illustrated that (DOX+Cur)-PMs not only displayed better tumor accumulation and tumor targeting, and more efficiently inhibited the growth of tumor in 4T1 tumor-bearing mice, but also induced significantly less pathological damage to the cardiac tissue in comparison with free DOX, even DOX-PMs and DOX-PMs+Cur. In summary, this targeted combinational micellar delivery system with DOX and Cur could be a promising vehicle in tumor therapy.

US$19.90

PMID: 27913127

DOI: 10.1016/j.ejpb.2016.11.033


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Landis, M.S.; Ryan, J.V.; ter Schure, A.F.H.; Laudal, D., 2015: Behavior of mercury emissions from a commercial coal-fired power plant: the relationship between stack speciation and near-field plume measurements. The reduction of divalent gaseous mercury (Hg(II)) to elemental gaseous mercury (Hg(0)) in a commercial coal-fired power plant (CFPP) exhaust plume was investigated by simultaneous measurement in-stack and in-plume as part of a collaborative study...

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Adair, T., 2007: HIV status and age at first marriage among women in Cameroon. Recent research has highlighted the risk of HIV infection for married teenage women compared with their unmarried counterparts (Clark, 2004). This study assesses whether a relationship exists, for women who have completed their adolescence (age 20...

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Plesnik, J.; Kuzinova, Z.; Kovalcikova, M., 1968: Results of crossing of Slovakian Pied with Danish Red cattle and dairy performance of F1 crosses in 1st-3rd lactations. In 26 Danish Red x Slovakian Pied (S.P.) in 1st, 2nd and 3rd lactations resp., milk yield averaged 3075.1, 2894.6 and 3187 kg, fat percentage 4.11, 4.08 and 3.82, and fat yield 127.1, 121.2 and 121.7 kg v 2292.0, 2582.1 and 2701 kg milk, 3.85, 3.9...

Sing, N.B.; Mostavan, A.; Hamzah, E.; Mantovani, D.; Hermawan, H., 2016: Degradation behavior of biodegradable Fe35Mn alloy stents. This article reports a degradation study that was done on stent prototypes made of biodegradable Fe35Mn alloy in a simulated human coronary arterial condition. The stent degradation was observed for a short-term period from 0.5 to 168 h, which sim...

Hermanson, J.W.; Moschella, M.C.; Ontell, M., 1988: Effect of neonatal denervation-reinnervation on the functional capacity of a 129ReJ dy/dy murine dystrophic muscle. The sciatic nerves of 14-day-old 129 ReJ normal (++) and dystrophic (dy/dy) mice were transected in the mid-thigh region. The cut ends of the nerves were approximated to facilitate regeneration. One hundred days after denervation, contractile prop...

Okólski, M., 1983: Abortion and contraception in Poland. Studies in Family Planning 14(11): 263-274