+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Cognitive impairment and magnetic resonance imaging correlates in primary progressive multiple sclerosis

, : Cognitive impairment and magnetic resonance imaging correlates in primary progressive multiple sclerosis. Acta Neurologica Scandinavica (): -

To characterize cognitive impairment in primary progressive multiple sclerosis (PPMS) and to correlate the pattern of cognitive deficits with brain magnetic resonance imaging (MRI) volumetric data. In a multicenter cross-sectional study, we recruited consecutive patients with PPMS as well as age, sex, and education level-matched healthy controls (HC). All participants underwent neuropsychological (NP) assessment, and brain MRI was performed in patients with PPMS for analysis of lesion load, subcortical GM volumes, and regional cortical volumes. We recruited 55 patients with PPMS and 36 HC. Thirty-six patients were included in the MRI analysis. Patients with PPMS performed significantly worse than HC in all NP tests. Subcortical GM volume was significantly correlated with all NP tests, except for Stroop Test, with the largest effect for the thalamus (r=-.516 [BVMT-R DR, P=.016 FDR-corrected] to r=.664 [SDMT, P<.001 FDR-corrected]). In the stepwise linear regression model, thalamic volume was the only predictor of performance in all NP tests. Cognitive impairment is common in PPMS and affects all evaluated cognitive domains. Subcortical GM volume, particularly of the thalamus, is a strong predictor of cognitive performance, suggesting it has a central role in the pathophysiology of PPMS-related cognitive dysfunction.


PMID: 27778334

DOI: 10.1111/ane.12702

Other references

Knabe, G.W., 1960: The development of a school of medical technology in El Salvador. American Journal of Clinical Pathology 34: 550-551

Gaur V.P.; Eldred W.; Sarthy P.V., 1988: Distribution of mueller cells in the turtle retina an immunocytochemical study. Mueller cells are the major type of glial cell in the vertebrate retina, and appear to participate in important structural and metabolic functions. Although the morphological features of Mueller cells have been extensively studied, their topograph...

Winkelmann, S.E.; Llorens, A.S., 1990: Metastatic basal cell carcinoma of the vulva. Basal cell carcinoma of the vulva is rare and was initially thought to be nonmetastasizing; however, there are four reports in the literature of metastasis to regional lymph nodes. We present the case report of a fifth patient with well-documented...

Ball, P., 1987: Oestrus detection in dairy cattle. In practice 9(6): 223

Steffen, M.J.; Holt, S.C.; Ebersole, J.L., 2000: Porphyromonas gingivalis induction of mediator and cytokine secretion by human gingival fibroblasts. We hypothesized that bacterial viability and strain characteristics of Porphyromonas gingivalis could affect the induction of pro-inflammatory mediator secretion by human gingival fibroblast cultures. Both killed and viable P. gingivalis elicited...

Kieu, V.; Yuen, A.; Tassone, P.; Hobbs, C.G., 2012: Cervical paraganglioma presenting as thyroid neoplasia. Otolaryngology--Head and Neck Surgery 146(3): 516-518

Groves, R.W.; Toms, G.C.; Houghton, B.J.; Monson, J.P., 1988: Corticosteroid replacement therapy: twice or thrice daily?. Although glucocorticoid replacement is conventionally administered twice daily, the pharmacokinetics of hydrocortisone would predict very low levels of plasma cortisol by mid-afternoon. This study compared plasma cortisol day profiles in 7 hypoadr...

Bhat K.G.; Dutt N.H.G., 1989: Histochemical localization of the steroidogenic enzymes in the ovary of puntius sarana hamilton. The ovary of Puntius sarana was histochemically studied for the distribution of glucose-6-phosphate dehydrogenase (G-6-PDH), .DELTA.5-3.beta.-hydroxysteroid dehydrogenase (.DELTA.5-3.beta. HSDH) and 17.beta.-hydroxysteroid dehydrogenase (17.beta.-...

O'Keefe, J.C.; Butrous, G.S.; Dymond, D.S.; Littlejohns, P.; Peters, N.; Banim, S.O., 1985: Ventricular arrhythmias complicating weight reduction therapy in a patient with a prolonged QT interval. Serious ventricular arrhythmias are known to occur in patients with long QT intervals. We describe a case of torsade de pointes occurring in a patient with a prolonged QT interval while taking a 1000 calorie diet, diethylpropion hydrochloride (Ten...

Crenshaw, J.T.; Adams, E.D.; Amis, D., 2016: Trends in Perinatal Care and Implications for Frontline Nurse Leaders. The perinatal trends presented in this article are based on recent topics from conferences, journals, the media, as well as from input from perinatal nurses. Trends in patient care are influenced by evidence known for decades, new research, emergi...