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Collagenase clostridium histolyticum in Dupuytren's contracture: a systematic review


, : Collagenase clostridium histolyticum in Dupuytren's contracture: a systematic review. British Medical Bulletin 118(1): 149-158

In the last few years, the use of collagenase clostridium histolyticum for management of Dupuytren's contracture has increased. The procedure of enzymatic fasciectomy has become popular because it is non-invasive, safe and fast to perform. A systematic search was performed on Medline (PubMed), Web of Science and Scopus databases using the combined keywords 'Dupuytren collagenase' and 'Dupuytren clostridium histolyticum'. Forty-three studies were identified. The quality of the studies was assessed using the Coleman Methodological Score. The use of collagenase clostridium histolyticum provides better outcomes in patients with mild-moderate joint contracture, with lower complications and side effects than open fasciectomy. Manipulation can be performed 2-7 days after the injection. The use of collagenase is cost-effective. Most of the studies did not report patient-related outcomes. The role of dynamic splint has to be investigated with randomized clinical trials. The shorter recovery time and the low incidence of serious or major adverse effects are the main advantages of this new technology. There is a need to perform studies with longer follow-up because the recurrence rate seems to increase with time. Further investigations are necessary to assess whether it is safe and effective to inject two or more cords at the same time.

US$19.90

PMID: 27151958

DOI: 10.1093/bmb/ldw020


Other references

Coleman, H.M., 1970: An analysis of the visual status of an entire school population. Journal of the American Optometric Association 41(4): 341-347

Baddesha, H.S.; Kuldip Singh, 1997: Evaluation of various chemical extractants for predicting cobalt availability to cowpea. A pot experiment with ten soils using cowpea (Vigna unguiculata) as a test crop was conducted with five levels of Co (0, 0.5, 1.0, 2.0, 3.0 ppm) with and without Rhizobium inoculation to investigate the relationship between the amount of Co extrac...

Smeets, E.E.J.W.; Span, P.N.; van Herwaarden, A.E.; Wevers, R.A.; Hermus, A.R.M.M.; Sweep, F.C.G.J.; Claahsen-van der Grinten, H.L., 2015: Molecular characterization of testicular adrenal rest tumors in congenital adrenal hyperplasia: lesions with both adrenocortical and Leydig cell features. Testicular adrenal rest tumors (TART) are one of the major long term complications in patients with congenital adrenal hyperplasia. Although several adrenal-like properties have been assigned to these benign lesions, the etiology has not been conf...

Anonymous, 1890: Observations sur quelques Scalidae du Bassin de Paris et description d'une Especs Nouvelle. Gyroscala stueri, n. sp., p. 142.

Mack, A.H.; Trías, M.K.; Mochrie, S.G.J., 2009: Precision optical trapping via a programmable direct-digital-synthesis-based controller for acousto-optic deflectors. We describe a simple-to-construct programmable direct-digital-synthesis-based controller for use with acousto-optic deflectors. Our controller corrects for nonlinear diffraction efficiency versus diffraction angle, provides superior stability, fun...

W.D., 1984: Experimental studies on a transplantable pulmonary adeno carcinoma in 615 strain mice p 615. The present transplantable pulmonary adenocarcinoma in the strain 615 mice (P615) is the 1st transplantable mouse lung tumor established in China. It was derived from a spontaneous pulmonary adenocarcinoma of a 615-strain mouse. After 58 generatio...

Anonymous, 2012: Evaluation of SDHB, SDHD and VHL gene susceptibility testing in the assessment of individuals with non-syndromic phaeochromocytoma and paraganglioma and head and neck paraganglioma HNPGL. Research studies have reported that about a third of individuals with phaeochromocytoma/paraganglioma (PPGL) have an inherited predisposition, though the frequency of specific mutations can vary between populations. We evaluated VHL, SDHB and SDHD...

Benter, W., 1952: Syncopal, vasomotoric attacks. Die Medizinische 20(37): 1155-1157

Duff, H.J.; Lester, W.; Kondo, C.S., 1994: Hypomagnesemia A model of sudden death. Circulation 90(4 PART 2): I248

Simmonds, John, 1995: ICES acoustic survey procedures. Canadian Technical Report of Fisheries & Aquatic Sciences 0(2083): 117-124