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Comparing Effects of Biologic Agents in Treating Patients with Rheumatoid Arthritis: A Multiple Treatment Comparison Regression Analysis


, : Comparing Effects of Biologic Agents in Treating Patients with Rheumatoid Arthritis: A Multiple Treatment Comparison Regression Analysis. Plos One 10(9): E0137258-E0137258

Rheumatoid arthritis patients have been treated with disease modifying anti-rheumatic drugs (DMARDs) and the newer biologic drugs. We sought to compare and rank the biologics with respect to efficacy. We performed a literature search identifying 54 publications encompassing 9 biologics. We conducted a multiple treatment comparison regression analysis letting the number experiencing a 50% improvement on the ACR score be dependent upon dose level and disease duration for assessing the comparable relative effect between biologics and placebo or DMARD. The analysis embraced all treatment and comparator arms over all publications. Hence, all measured effects of any biologic agent contributed to the comparison of all biologic agents relative to each other either given alone or combined with DMARD. We found the drug effect to be dependent on dose level, but not on disease duration, and the impact of a high versus low dose level was the same for all drugs (higher doses indicated a higher frequency of ACR50 scores). The ranking of the drugs when given without DMARD was certolizumab (ranked highest), etanercept, tocilizumab/ abatacept and adalimumab. The ranking of the drugs when given with DMARD was certolizumab (ranked highest), tocilizumab, anakinra/rituximab, golimumab/ infliximab/ abatacept, adalimumab/ etanercept [corrected]. Still, all drugs were effective. All biologic agents were effective compared to placebo, with certolizumab the most effective and adalimumab (without DMARD treatment) and adalimumab/ etanercept (combined with DMARD treatment) the least effective. The drugs were in general more effective, except for etanercept, when given together with DMARDs.

US$19.90

PMID: 26356639

DOI: 10.1371/journal.pone.0137258


Other references

Purser, Philip A., 2003: Chorus of the night. Care and maintenance of five popular treefrogs. Reptilia (GB). June; 28: 22-25

Pflueger S.M.V.; Covall D.J.; Kruger L.M., 1987: Marfanoid habitus with bowing of the long bones hypertrophy hyperplasia of the great toe with short 2 5 metatarsals and slipped capital femoral epiphyses a new syndrome. American Journal of Human Genetics 41(3 SUPPL): A78

Yang, S.-Yung; Suh, J.-Hwa; Min, M.-Sook; Kang, Y.-Jin; Kim, J.-Bum, 2000: Genetic variation and divergency in two Korean Bufo species, Bufo gargarizans and B. stejnegeri (Anura, Bufonidae). To elucidate genetic variability and genetic relationships of 21 populations of two Bufo species in Korea and China, allozyme analysis was performed. The average genetic variability of B. stejnegeri (Ho=0.090 and He=0.088) was moderate in comparis...

Harkness, R.D., 1964: The structure and metabolism of collagen. Progress in the biological sciences in relation to dermatology 3-23

Becklake, M.R.; Irwig, L.; Kielkowski, D.; Webster, I.; de Beer, M.; Landau, S., 1987: The predictors of emphysema in South African gold miners. Environmental and host factors have been implicated in the pathogenesis of emphysema. To assess the role of gold mining exposure (an environmental factor) and of various clinical features recorded early in a miner's career (host factors), a c...

Arthur J.Flexser,Gordon H.Bower, 1975: Further evidence regarding instructional effects on frequency judgments. Bulletin of the Psychonomic Society 6(3): 321-324

Inoue, M.; Kofuji, H.; Yamamoto, M.; Komura, K., 2005: Seasonal variation of 228Ra/226Ra ratio in seaweed: implications for water circulation patterns in coastal areas of the Noto Peninsula, Japan. To examine water circulation patterns of coastal water, 72 seaweed (Sargasso) samples and 27 coastal water samples were collected from coastal areas of the Noto Peninsula, Japan, during the period from December 1998 to June 2002. The 228Ra and 226...

Achour, A.; Picard, O.; Mbika, J.-Pierre; Willer, A.; Snart, R.; Bizzini, B.; Carelli, C.; Burny, A.; Zagury, D., 1993: Envelope protein and p18(IIIB) peptide recognized by cytotoxic T lymphocytes from humans immunized with human immunodeficiency virus envelope. Cytotoxic T cells are the main antigen-specific effector cells of the cellular immune system and MHC class I restricted cytotoxic T-lymphocyte (CTL) responses in mice, acting against the HIV-1 envelope protein, are known to be predominantly direct...

Guttmann R.D., 1976: Lymphocyte determinant relationship to the rejection and enhancement of rat cardiac allo grafts. Federation Proceedings 35(3): 649

Borland, C.A.; Barber, M.C.; Travers, M.T.; Vernon, R.G., 1993: Inhibition of adipose tissue lipogenesis by growth hormone: role of polyamines. Biochemical Society Transactions 21(4): 400s-400s