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Comparison of Insulin Resistance to Coronary Atherosclerosis in Human Immunodeficiency Virus Infected and Uninfected Men (from the Multicenter AIDS Cohort Study)


, : Comparison of Insulin Resistance to Coronary Atherosclerosis in Human Immunodeficiency Virus Infected and Uninfected Men (from the Multicenter AIDS Cohort Study). American Journal of Cardiology 117(6): 993-1000

The relation between insulin resistance (IR) and coronary artery disease in patients with human immunodeficiency virus (HIV) infection remains incompletely defined. Fasting serum insulin and glucose measurements from 448 HIV-infected and 306 uninfected men enrolled in the Multicenter AIDS Cohort Study were collected at semiannual visits from 2003 to 2013 and used to compute the homeostatic model assessment of IR (HOMA-IR). Coronary computed tomographic angiography (CTA) was performed at the end of the study period to characterize coronary pathology. Associations between HOMA-IR (categorized into tertiles and assessed near the time of the CTA and over the 10-year study period) and the prevalence of coronary plaque or stenosis ≥50% were assessed with multivariate logistic regression. HOMA-IR was higher in HIV-infected men than HIV-uninfected men when measured near the time of CTA (3.2 vs 2.7, p = 0.002) and when averaged over the study period (3.4 vs 3.0, p <0.001). The prevalence of coronary stenosis ≥50% was similar between both groups (17% vs 15%, p = 0.41). Both measurements of HOMA-IR were associated with greater odds of coronary stenosis ≥50% in models comparing men with values in the highest versus the lowest tertiles, although the effect of mean HOMA-IR was stronger than the single measurement of HOMA-IR before CTA (odds ratio 2.46, 95% CI 1.95 to 3.11, vs odds ratio 1.43, 1.20 to 1.70). This effect was not significantly modified by HIV serostatus. In conclusion, IR over nearly a decade was greater in HIV-infected men than HIV-uninfected men, and in both groups, was associated with significant coronary artery stenosis.

US$19.90

PMID: 26830260

DOI: 10.1016/j.amjcard.2015.12.037


Other references

Enna, S.J.; Duman, R.S., 1983: beta-Adrenergic receptor regulation and antidepressants: the influence of adrenocorticotropin. Chronic administration of antidepressants reduces brain beta-adrenergic receptor number and function. Peptide and steroid hormones are also capable of modifying receptor activity, and because circulating levels of these substances are altered in d...

Kiriukhin, G., 1947: Les cochenilles farineuses et leurs parasites en Iran (sous-famille : Pseudoooccinae).. The author reviews the habits and control of mealybugs and gives a list of eight species that have been observed on cultivated plants in northern Persia, with notes on adult morphology and distribution. They are Pseudococcus adonidum (L.), which o...

Keeley, P.; Thullen, R., 1977: Metabolic fate of methazole in purple (Cyperus rotundus L.) and yellow nutsedge (Cyperus esculentus L.). Abstracts 3-94

Reynaud-Hautin, C., 2006: Neutrophilic eccrine hidradenitis in a healthy young woman. Annales de Dermatologie et de Venereologie 133(10): 806-807

Bernardi, F.; Genevieve, F.; Maschke, S.; Copin, M.C.; Bauters, F.; Facon, T.; Lai, J.L.; Zandecki, M., 1996: Chromatin network of plasma cells and occurrence of cytogenetic changes in multiple myeloma. British Journal of Haematology 93(SUPPL 2): 130

Stremme, H., 1916: Uber die durch Bandverknocherung hervorgerufene proximale Verschmelzung zweier Mittelhand- oder Mittelfussknochen eines Reptile. Arch. Berlin: 141-144

Paddick, R.G.; French, F.L., 1972: Suppression of tobacco yellow dwarf with systemic organophosphorus insecticides. DDT kills Orosius argentatus (Evans), the vector of the tobacco yellow dwarf virus, on tobacco in Victoria, but does not control the disease, which has recently become prevalent there. J.W. Meagher and the authors found in work with nematicides in...

Pens, F., 1926: Andrena nycthemera Imhoff im Munsterlande Hym Apid. Deutsche Entomologische Zeitschrift, 101-103

Hubrig, T.; Wohanka, K., 1959: Differentiation of vibrios isolated from the bovine genital system. I-VI. These six papers were read at a symposium on bovine genital vibriosis, organized by the German Academy of Agricultural Sciences and held at Jena in May 1958.

Nemeth, S., 1962: Considerations on thyrotoxicosis treatment with antithyroid drugs. Endokrynologia Polska 13: 59-62