+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Comparison of efficacy and safety of topical versus intravenous tranexamic acid in total hip arthroplasty: A meta-analysis

, : Comparison of efficacy and safety of topical versus intravenous tranexamic acid in total hip arthroplasty: A meta-analysis. Medicine 95(36): E4689-E4689

The study aimed to compare the effectiveness and safety of topical versus intravenous (IV) tranexamic acid (TXA) for reducing blood loss in primary total hip arthroplasty (THA). This systematic review and meta-analysis were performed according to the preferred reporting items for systematic reviews and meta-analyses statement criteria. PubMed, Embase, the Cochrane Library, Web of Science, Chinese Biomedicine Literature (CBM), Wanfang Database, China National Knowledge Infrastructure (CNKI), and Google Scholar were searched for randomized controlled trials (RCTs) and non-RCTs that compare topical versus IV-TXA administration for reducing blood loss during TKA from their inception to February, 2016. Meta-analysis was performed by Stata 12.0 software. Seven studies comprising 2056 patients were included in this meta-analysis. No significant difference is found between topical TXA groups and IV-TXA groups regarding transfusion requirements (RR = 1.37, 95% confidence interval [CI]: 0.96-1.97, P = 0.083), total blood loss (MD 17.09, 95% CI: -33.74-67.91, P = 0.510), and hemoglobin decline (MD 0.32, 95%CI: -0.04-0.69, P = 0.122). Meanwhile, there is no significant difference in terms of the occurrence of deep venous thrombosis (RR = 1.09, 95% CI: 0.40-3.90, P = 0.869). Topical TXA has a similar efficacy to IV-TXA in reducing both blood loss and transfusion rate without sacrificing safety in primary THA.


PMID: 27603364

DOI: 10.1097/MD.0000000000004689

Other references

Crawford, J.; Berry, R.J., 1900: The Stomach and Pylorus. Journal of Anatomy and Physiology 34(Pt 2): 153-158.7

Yoshida, Y.; Takei, K., 2006: Stimulation of dynamin GTPase activity by amphiphysin. Dynamin functions in the fission of endocytic pits in the process of clathrin-mediated endocytosis. Dynamin GTPase activity is essential for its fission activity, and it is stimulated by self-assembly as well as by interacting with its binding par...

Czarnecka, J.; Kitowski, I., 2013: The White Stork as an Engineering Species and Seed Dispersal Vector when Nesting in Poland. The white stork can affect plant population and community dynamics and structure in an agricultural landscape. It is a vector transporting large numbers of seeds along with nest material, and it is an ecosystem engineer which builds nests that fun...

Arnold, A.S.; Asakawa, D.J.; Delp, S.L., 2000: Do the hamstrings and adductors contribute to excessive internal rotation of the hip in persons with cerebral palsy?. Children with cerebral palsy frequently walk with excessive internal rotation of the hip. Spastic medial hamstrings or adductors are presumed to contribute to the excessive internal rotation in some patients; however, the capacity of these muscles...

Yoshida T.; Gomita Y.; Furuno K.; Itoh Y.; Oishi R.; Araki Y.; Saeki K., 1990: Effect of cigarette smoke on the pharmacokinetics of indomethacin administered orally and intrarectally to rats. European Journal of Pharmacology 183(6): 2289

Wu, C.J.; Huang, J.L.; Yang, M.H.; Yan, D.C.; Ou, L.S.; Ho, H.H., 2001: Clinical characteristics of juvenile rheumatoid arthritis in Taiwan. This study aimed to investigate the clinical features of juvenile rheumatoid arthritis among Taiwan children. The medical records of 228 children who had juvenile rheumatoid arthritis treated in the Chang Gung Medical Center in Taiwan from 1978 th...

Ness Norman F., 1966: Earth's magnetic field-a new look. Science 151(3714): 1041-1052

Magnée, T.; de Beurs, D.P.; de Bakker, D.H.; Verhaak, P.F., 2016: Consultations in general practices with and without mental health nurses: an observational study from 2010 to 2014. To investigate care for patients with psychological or social problems provided by mental health nurses (MHNs), and by general practitioners (GPs) with and without MHNs. An observational study with consultations recorded by GPs and MHNs. Data were...

Herrero, M.L.z; Klemsdal, S.S.etner, 1998: Identification of Pythium aphanidermatum using the RAPD technique. The suitability of random amplified polymorphic DNA for identification of Pythium aphanidermatum was investigated. Three oligoprimers were selected after testing three isolates of P. aphanidermatum and one isolate of P. ultimum with a total of 40...

Argyroudi-Akoyunoglou, J.; Akoyunoglou, G., 1971: Analysis of chlorophyll and other porphyrin hydrolysates in the amino acid analyser. Photosynthetica (2) 153-159