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Concurrent sorafenib therapy extends the interval to subsequent TACE for patients with unresectable hepatocellular carcinoma

, : Concurrent sorafenib therapy extends the interval to subsequent TACE for patients with unresectable hepatocellular carcinoma. Journal of Surgical Oncology 113(6): 672-677

To compare the impact of concurrent TACE + sorafenib versus TACE alone on overall survival (OS) and time to progression (TTP) in patients with unresectable hepatocellular carcinoma (uHCC). A secondary goal was to determine if sorafenib use increases the interval between courses of TACE. This study enrolled 150 patients with uHCC from June 2011 to June 2014, including 50 treated with TACE + sorafenib and 100 treated with TACE alone. Factors associated with OS and TTP were identified by univariate and multivariate Cox-regression model analyses. Average TACE interval was defined as TTP/TACE frequency. The median OS (21.7 vs. 11.5 months) and TTP (10.2 vs. 6.7 months) were longer in the TACE + sorafenib group compared to the TACE group. Patients receiving combination therapy had higher survival rate (P < 0.032) and longer average interval to TACE (P < 0.001), but lower progression rate (P < 0.001). TACE + sorafenib therapy was associated with improved OS (P ≤ 0.009) and TTP (P ≤ 0.021). The majority of AEs identified in patients receiving the combination therapy were classified as Grades 1 and 2, and skin-related reactions and fatigue were the most common. Concurrent sorafenib with TACE provides survival benefits over TACE monotherapy, which may be related to a prolonged interval between subsequent TACE courses. J. Surg. Oncol. 2016;113:672-677. © 2016 Wiley Periodicals, Inc.


PMID: 26989044

DOI: 10.1002/jso.24215

Other references

Schlett, C., 1993: Determination of pesticides by HPLC. Using solid phase extraction followed by HPLC, various pesticides of different chemical structure, thermolabile or polar components included, can be separated and quantitated chromatographically in a single run. Due to longer elution times compare...

Cone L.A.; Woodard D.R.; Potts B.E.; Byrd R.G.; Alexander R.M.; Last M.D., 1986: An update on the acquired immunodeficiency syndrome associated disorders of the alimentary tract. The pandemic, acquired immunodeficiency syndrome (AIDS) has been described in 40 nations throughout the world. This paper describes the wide spectrum of gastrointestinal tract manifestations seen in this syndrome, with particular attention to the...

Ogilvie, J., 2001: Swimming with dolphins. Trends in Cognitive Sciences 5(6): 234-234

Janerich, D.T., 1971: Sex ratio and season of birth. Lancet 1(7704): 865-865

Rabano I.; Arbizu M., 1999: Cases of trilobite malformations in Spain. Revista Espanola de Paleontologia Numero extraordinario: 109-113

Linke, G.; Schröder, K., 1968: The loudness determination by workers in noisy surroudings. On problems of getting accustomed to noise. Zeitschrift für Laryngologie, Rhinologie, Otologie und Ihre Grenzgebiete 47(1): 53-57

Saxl, O.; Keleti, J.; Janouskova, I.; Mlynarcik, D.; Nemcova, J., 1968: Importance of dried milk preparations for the development and prevention of dietary methaemoglobinaemia. Capacity of reconstituted dried milk preparations Lakton, Eviko, Relakton and Sunar (for composition see DSA 32 &) to reduce nitrate to nitrite was tested in the presence and absence of Escherichia coli and Bacillus subtilis preparations and in th...

Mercken L.; Pillen R., 1987: Coelambus lautus new species schaum 1843 to the belgian fauna coleoptera dytiscidae hydroporinae. Bulletin & Annales de la Societe Royale Belge d'Entomologie 123(10-12): 360-362

Finney, D.J., 1951: Biological assay. Methods of biological assay are discussed and the statistical design and analysis of results for each method are outlined.

Pantuliano, S., 2009: Letters raised points about food aid intervention of international organisations. Disasters 33(3): 498-500