geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Controlled release of indomethacin from alginate-poloxamer-silicon carbide composites decrease in-vitro inflammation


, : Controlled release of indomethacin from alginate-poloxamer-silicon carbide composites decrease in-vitro inflammation. International Journal of Pharmaceutics 480(1-2): 92-100

Composites of biomorphic silicon carbides (bioSiCs) and hydrogels are proposed in order to obtain materials able to load and release poor soluble drugs with application in bone pathologies therapy. Hydrogels composed by alginate and poloxamer were loaded with indomethacin, incorporated into the ceramics and crosslinked. The indomethacin release profile is dependent on the microstructure of the bioSiC selected. The loaded oak and sapelli bioSiCs composites have adequate release profiles to promote the decreasing of the secretion of pro-inflammatory cytokines in LPS stimulated macrophages, showing stronger anti-inflammatory effects than pine bioSiC composites. The released indomethacin is able to modulate the degradation of chondrocytes extracellular matrix and promote the formation of new collagen by osteoarthritic chondrocytes. Particles derived from mechanical wear of biomorphic silicon carbides do not show high toxicity, being similar to the zirconia particles.

US$19.90

PMID: 25596416

DOI: 10.1016/j.ijpharm.2015.01.021


Other references

Hallam Anthony, 1960: Kulindrichnus langi, a new trace-fossil from the Lias. Kulindrichnus langi n.g. n.sp. from lower Liassic zones of England, Scotland, and Wuerttemberg, Germany, "is stumpy cylindrical or conical in shape and is formed of a shell aggregate often enveloped by a phosphatic sheath. It is interpreted a...

Signoret J.P.; Lindsay D.R., 1982: The male effect in domestic mammals effect on luteinizing hormone secretion and ovulation importance of olfactory cues. Breipohl, W (Ed ) Olfaction And Endocrine Regulation; Proceedings Of The 4th European Chemoreception Research Organization Symposium And The 2nd International Laboratory Workshop on Olfaction, Schloss Lembeck, West Germany, Oct 11-15, 1981 Xiv+409p Irl Press: London, England Illus Paper P63-72

Singh, T., 1982: Weight tables for important tree species in the Prairie Provinces. Tables are presented relating above-ground dry wt. (without foliage) to ht. and d.b.h., based on samples of 60 trees each of Abies balsamea, A. lasiocarpa, Betula papyrifera, Larix laricina, Picea glauca, P. mariana, Pinus banksiana, P. contorta,...

Schinckel, A.; Li, N.R.chert, B.; Preckel, P.; Foster, K.E.nstein, M., 2006: Development of a model to describe the compositional growth and dietary lysine requirements of pigs fed increasing dietary concentrations of ractopamine. Professional animal scientist 22(6): 438-449

Pérez Soler, J., 1972: Cancer of the cervix and pregnancy. Brief review of its current status. Acta Obstetrica Y Ginecologica Hispano-Lusitana 20(2): 105-126

el-Hag, T.A.; Mekkawi, M.F.; el-Sheyati, M.F.; Eid, S.Z., 1976: Blood vitamin "A" level and dark adaptation. Bulletin of the Ophthalmological Society of Egypt 69(73): 653-660

Pandya, M.; Wittum, T.; Tadesse, D.A.; Gebreyes, W.; Hoet, A., 2010: Environmental Salmonella surveillance in the Ohio State University Veterinary Teaching Hospital. Sampling was conducted at The Ohio State University's Veterinary Teaching Hospital (OSU-VTH) to evaluate the extent of environmental contamination with Salmonella enterica, at 1-week intervals beginning March 19, 2007, through May 21, 2007. E...

Woodrow, P., 2002: Assessing respiratory function in older people. Nursing Older People 14(3): 27-28

Pini, M.; D'Acunzo, L.; Giudici, G., 1966: The action of RNA on irradiated skin. Minerva Fisiconucleare 10(2): 175-177

Ishihara S.; Sasaki A.; Shibata K.; Terashima S.; Matsuhisa Yukihiro, 1985: Characteristics of Cretaceous magmatism and related mineralization of the lower Yangtze area, Eastern China. Pages 23-48 1985