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Correlation between red blood cell transfusion volume and mortality in patients with massive blood transfusion: A large multicenter retrospective study

, : Correlation between red blood cell transfusion volume and mortality in patients with massive blood transfusion: A large multicenter retrospective study. Experimental and Therapeutic Medicine 9(1): 137-142

This study aimed to explore the correlation between red blood cell (RBC) transfusion volume and patient mortality in massive blood transfusion. A multicenter retrospective study was carried out on 1,601 surgical inpatients who received massive blood transfusion in 20 large comprehensive hospitals in China. According to RBC transfusion volume and duration, the patients were divided into groups as follows: 0-4, 5-9, 10-14, 15-19, 20-24, 25-29, 30-39 and ≥40 units within 24 or 72 h. Mortality in patients with different RBC transfusion volumes was analyzed. It was found that patient mortality increased with the increase in the volume of RBC transfusion when the total RBC transfusion volume was ≥10 units within 24 or 72 h. Survival analysis revealed significant differences in mortality according to the RBC transfusion volume (χ2=72.857, P<0.001). Logistic regression analysis revealed that RBC transfusion volume is an independent risk factor [odds ratio (OR) = 0.52; confidence interval (CI): 0.43-0.64; P<0.01] for the mortality of patients undergoing a massive blood transfusion. When RBCs were transfused at a volume of 5-9 units within 24 and 72 h, the mortality rate was the lowest, at 3.7 and 2.3% respectively. It is concluded that during massive blood transfusion in surgical inpatients, there is a correlation between RBC transfusion volume within 24 or 72 h and the mortality of the patients. Patient mortality increases with the increase in the volume of RBC transfusion. RBC transfusion volume, the length of stay at hospital and intensive care unit stay constitute the independent risk factors for patient mortality.


PMID: 25452789

DOI: 10.3892/etm.2014.2068

Other references

Caicedo R.; Guadalupe; Vargas G.; Hector; Gaviria M.; Jaime, 1993: Evaluacion de Xylocopa spp. (Hymenoptera: Anthophoridae) como polinizadores en el cultivo del maracuya (Passiflora edulis var. flavicarpa Degener). Revista Colombiana de Entomologiajulio-septiembre; ): 107-110

Rondini, G.; Bozzola, M.; Altamura, D.; Livieri, C.; Ugazio, A.G., 1976: Early introduction of lyophilized meat in low-weight newborn infant diet. Growth and cell immunity parameters. Minerva Pediatrica 28(1): 44-49

Contoux, C.; Violette, S.; Vivona, R.; Goblet, P.; Patriarche, D., 2013: How basin model results enable the study of multi-layer aquifer response to pumping; the Paris Basin, France. The Albian aquifer of the Paris Basin (France) has been exploited since 1841 and shows drastic drawdown. A three-dimensional (3D) groundwater flow model is used to study the hydrodynamic response of the multi-layered aquifers to pumping activity i...

Moron, S.E.; Fernandes, M.N., 1996: Pavement cell ultrastructural differences on Hoplias malabaricus gill epithelia. Pavement cells from the leading and trailing edges of the gill filament of Hoplias malabaricus exhibit a complex system of microridges, a long tight junction and a large number of desmosomes. Pavement cells from the secondary lamellae are smooth s...

Posse, S.; Fitzgerald, D.; Habel, U.; Rosenberg, D.; Moore, G.J.; Schneider, F., 2002: Real time functional magnetic resonance imaging of amygdala hippocampus activation during self induced sadness. A new real-time multi-echo fMRI technique with gradient compensation of susceptibility related signal losses was used to measure activation in amygdala and hippocampus during 60 s trials of self-induced sadness. 9 healthy adults (3 males, 6 female...

Sagar, A.; Vaidyanath, K.; Prabhakar, M., 1990: Morphogenesis in cotyledon derived nodular callus of cajanus cajan l. millsp. Regeneration of plants from cotyledonary nodular callus has been achieved by a one-step method employing B5, Blaydes, or L6 medium supplemented with 0.1-2.25 mg/l 6-benzylaminopurine (BAP). The frequency of explanted cotyledons giving rise to rege...

Karle, H., 1968: Elevated body temperature and the survival of red blood cells. A study on experimental pyrexia in rabbits. Acta Medica Scandinavica 183(6): 587-592

Anonymous, 1986: Sightseeing in 1985. Statistics and information on trends in supply, revenue, overseas visitors, opening hours, admission charges, demand relative to capacity, capital expenditure and employment aspects of 2918 tourist attractions in England are provided. A special su...

Mayr, A., 1973: Environment and zoonoses. Das Offentliche Gesundheitswesen 35(11): 637-646

Chamoles, Néstor.A.; Blanco, M.; Gaggioli, D.; Casentini, C., 2002: Gaucher and Niemann-Pick diseases--enzymatic diagnosis in dried blood spots on filter paper: retrospective diagnoses in newborn-screening cards. Gaucher disease (GD) and Niemann-Pick (NP) disease are caused by deficient activity of the lysosomal enzymes acid beta-D-glucosidase (ABG) and acid sphingomyelinase (ASM), respectively. For diagnosis, these enzymes are usually measured in the extr...