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Correlation of molecular HLA typing and outcome in high-risk melanoma patients receiving adjuvant interferon


, : Correlation of molecular HLA typing and outcome in high-risk melanoma patients receiving adjuvant interferon. Journal of Clinical Oncology 24(18_suppl): 8029-8029

NlmCategory="UNASSIGNED">8029 Background: Serological typing for both HLA class I and class II antigen expression, has previously shown association of specific HLA antigen expression with clinical response and survival in patients with metastatic melanoma treated with IL-2 (e.g. HLA-DQ1). To evaluate the impact of HLA class I (low-resolution) and class II (high-resolution) expression, on the outcome of high-risk melanoma patients receiving adjuvant high-dose interferon. 181 stage IIB, IIC and III melanoma patients (88 female and 93 male), median age 52.1 years and 246 healthy controls were included in this study. DNA was used for the determination of HLA-A, HLA-B, HLA-Cw, HLA-DRB1 and HLA-DQB1 genotypes. With a median follow-up of 37 months, 59 (group 1) patients have remained with no evidence of recurrence and 122 have recurred (group 2). Statistical significant differences between the two groups, were found in the following genotypes: HLA-A*02 (42% vs. 57.3%, p=0.08), HLA-A*33 (15.2% vs. 6.5%, p=0.05), HLA-B*51 (15.2% vs. 34.4%, p=0.01), HLA-B*57 (11.8% vs. 2.4%, p=0.02). Statistical significant differences between group 1 and healthy controls, were found in the following genotypes: HLA-A*33 (15.2% vs. 6.5%, p=0.05), HLA-B*51 (15.2% vs. 28.5%, p=0.05), HLA-B*57 (11.8% vs. 4.5%, p=0.05), HLA-Cw*03 (23.7% vs. 11%, p=0.01), HLA-Cw*06 (27.1% vs. 16.1%, p=0.06), HLA-DRB1*0701 (27.1% vs. 13.4%, p=0.01), HLA-DRB1*1601 (35.6% vs. 22.3%, p=0.01), HLA-DQB1*0202 (23.8% vs. 10.1%, p=0.09). Statistical significant differences were seen in HLA-A and HLA-B alleles between the patients with high-risk melanoma free of recurrence and those who recurred after treatment with adjuvant interferon. Additionally, differences were seen between healthy controls and melanoma patients free of recurrence. No significant financial relationships to disclose.

US$29.90

PMID: 27955559


Other references

Serpell, R.; Mariga, L.; Harvey, K., 1993: Mental retardation in African countries Conceptualization, services, and research. Bray, N W International Review of Research in Mental Retardation : 1-39

Lu, Yun; Chen, Heping; Verkman, Alan S.; Skach, William R., 1998: Topologic reorientation of AQP1 at the ER membrane. Molecular Biology of the Cell 9(SUPPL ): 346A, Nov

Abrahamson, S., 1985: Risk estimate for genetic effects. Basic Life Sciences 33: 223-250

Meyers, P.H.; Becker, H.C.; Sweeney, J.W.; Nice, C.M.; Nettleton, W.J., 1963: Evaluation Of A Computer-Retrieved Radiographic Image. An evaluation of computer-retrieved radiographic images is presented. The method, results, and significance of this technic are discussed. It remains for a group composed of radiologists, bio-medical engineers, and computer experts, to design and...

Muench, M.V.; Baschat, A.A.; Oyelese, Y.; Kush, M.L.; Mighty, H.E.; Malinow, A.M., 2008: Gravid hysterectomy: a decade of experience at an academic referral center. OBJECTIVE: To evaluate the incidence of gravid hysterectomy (GH) and to examine the indications as well as risk factors and complications associated with the procedure at an academic perinatal referral center.STUDY DESIGN: Rctrospective chart rev...

Engel, J.; Luboshitz, S.; Israeli, A.; Ganel, A., 1981: Tenography in De Quervain's disease. This paper describes our diagnostic method, which enables an early and immediate differentiation between those patients who could benefit from a single or several local corticosteroid injections, and those who will probably require surgery. The au...

Bekeny G., 1981: Observations on dys kalemic myopathies. Zentralblatt fuer Allgemeine Pathologie und Pathologische Anatomie 125(1): 79

Thursby M.H.; Nevis A.H., 1975: Effects of brain excitability on the level of taurine in rat brain. Biophysical Journal 15(2 PT 2): 128A

Wild, J.M.; Paley, M.N.J.; Viallon, M.; Schreiber, W.G.; Van Beek, E.J.R.; Griffiths, P.D., 2002: K-space filtering in 2D gradient-echo breath-hold hyperpolarized 3He MRI: Spatial resolution and signal-to-noise ratio considerations. In this work some of the factors that can influence the signal-to-noise ratio (SNR) and spatial resolution in MR images of inhaled hyperpolarized gases are systematically addressed. In particular, the effects of RF depletion of longitudinal polari...

Crowson R.A.; Showers William J.; Riggs S.R., 1990: Oxygen isotope geochemistry of Miocene phosphate grains from Onslow Bay, N.C.; evidence for Miocene Western Boundary Current induced upwelling. Abstracts with Programs - Geological Society of America 22(7): 354-355