geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Cost of skeletal complications from bone metastases in six European countries


, : Cost of skeletal complications from bone metastases in six European countries. Journal of Medical Economics 19(6): 611-618

Objective Patients with bone metastases or lesions secondary to solid tumors or multiple myeloma often experience bone complications (skeletal-related events [SREs]-radiation to bone, pathologic fracture, surgery to bone, and spinal cord compression); however, recent data that can be used to assess the value of treatments to prevent SREs across European countries are limited. This study aimed to provide estimates of health resource utilization (HRU) and cost associated with all SRE types in Europe. HRU data were reported previously; cost data are reported herein. Methods Eligible patients from 49 centers across Austria (n = 57), the Czech Republic (n = 59), Finland (n = 60), Greece (n = 59), Portugal (n = 59), and Sweden (n = 62) had bone metastases or lesions secondary to breast, lung, or prostate cancer, or multiple myeloma, and ≥1 index SRE (a SRE preceded by a SRE-free period of ≥ 6.5 months). SRE-related costs were estimated from a payer perspective using health resource utilization data from patient charts (before and after the index SRE diagnosis). Country-specific unit costs were from 2010 and local currencies were converted to 2010 euros. Results The mean costs across countries were €7043, €5242, €11,101, and €11,509 per radiation to bone, pathologic fracture, surgery to bone, and spinal cord compression event, respectively. Purchasing power parity (PPP)-adjusted mean cost ratios were similar in most countries, with the exception of radiation to bone. Limitations The overall burden of SREs may have been under-estimated owing to home visits and evaluations outside the hospital setting not being reported here. Conclusions All SREs were associated with substantial costs. Variation in SRE-associated costs between countries was most likely driven by differences in treatment practices and unit costs.

US$19.90

PMID: 26849381

DOI: 10.3111/13696998.2016.1150852


Other references

Salk, J.E., 1958: How many injections of poliomyelitis vaccine for effective and durable immunity. Journal of the American Medical Association 167(1): 1-7

Hassankhani, G.Ghayyem.; Moradi, A.; Vahedi, E.; Hoseinian, S.Hadi.Sayyed.; Jahani, Z.; Rahmani, M.; Ebrahimzadeh, M.H., 2017: Psychometric Properties of the Persian Version of the Patient Rated Wris t Evaluation. The patient-rated wrist evaluation (PRWE) score is one of the most common clinical instruments used as an outcome measurement tool for distal radius fractures and other upper extremity conditions. The purpose of this study was to translate the PRW...

Flood, A.A.; Fitzgerald, K.T., 2007: The poison-proof practice. Toxicology is the medical discipline that studies the often dramatic effects that poisons can have on living organisms. The body of toxicological information that the practicing veterinarian must deal with is growing exponentially. The veterinary...

Stancanelli, V.; Georgacopulo, P.; Azzena, G.F., 1965: Aortic Compressor For Partial Flow. Minerva Chirurgica 20: 184-186

Ogawva, K.; Yamawaki, I.; Matsusita, Y.I.; Nomura, N.; Kador, P.F.; Kinoshita, J.H., 1993: Syntheses of substituted 2,4-dioxothienopyrimidin-1-acetic acids and their evaluation as aldose reductase inhibitors. A series of 2,4-dioxo-thieno(2,3-d), (3,2-d) and (3,4-d)pyrimidin-1-acetic acids (2) with a benzyl moiety at the N-3 position were prepared and tested in vitro for aldose reductase inhibitory activity against partially purified enzyme from rat len...

Todorova, A.; Pesheva, M.; Iliev, I.; Bardarov, K.; Todorova, T., 2017: Antimutagenic, Antirecombinogenic, and Antitumor Effect of Amygdalin in a Yeast Cell-Based Test and Mammalian Cell Lines. Amygdalin is a major component of the seeds of Rosaceae family of plants such as apricots, peaches, cherry, nectarines, apples, plums, and so on, as well as almonds. It is used in alternative medicine for cancer prevention, alleviation of fever, c...

Gordon, J.D.M., 1977: The fish populations in inshore waters of the west coast of scotland the food and feeding of the whiting merlangius merlangus. The food and feeding of M. merlangus along the inshore waters and sea lochs of the west of Scotland were studied from 1969-1973. Fish and crustacea were the main food items and their occurrence in the stomachs was clearly related to the size of th...

Gemayel, C.Y.; Habboub, A.; Boden, W.E.; Gallagher, R.C.; Smith, B.; Carl, L.V.; Gillam, L.D., 2001: Impact of general anesthesia on the severity of functional tricuspid regurgitation An argument for surgical decision-making based on physiologic data from the awake patient. Circulation 104(17 Supplement): II 676-II 677, October 23

Bohle, D.S.; Helms, J.B., 1993: Synthesis of beta-hematin by dehydrohalogenation of hemin. beta-Hematin, the metalloporphyrin coordination polymer present in malaria pigment, is prepared in high yield by the abstraction of HCl from hemin with a non-coordinating base in strictly anhydrous conditions. The product of this preparation is ch...

Price, T.E., 1993: Global budgets--the golden rule. Journal of the Medical Association of Georgia 82(4): 165-167