geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Cost-Value Analysis and the SAVE: A Work in Progress, But an Option for Localised Decision Making?


, : Cost-Value Analysis and the SAVE: A Work in Progress, But an Option for Localised Decision Making?. Pharmacoeconomics 33(12): 1281-1288

Cost-value analysis aims to address the limitations of the quality-adjusted life-year (QALY) by incorporating the strength of public concerns for fairness in the allocation of scarce health care resources. To date, the measurement of value has focused on equity weights to reflect societal preferences for the allocation of QALY gains. Another approach is to use a non-QALY-based measure of value, such as an outcome 'equivalent to saving the life of a young person' (a SAVE). This paper assesses the feasibility and validity of using the SAVE as a measure of value for the economic evaluation of health care technologies. A web-based person trade-off (PTO) survey was designed and implemented to estimate equivalent SAVEs for outcome events associated with the progression and treatment of early-stage breast cancer. The estimated equivalent SAVEs were applied to the outputs of an existing decision analytic model for early breast cancer. The web-based PTO survey was undertaken by 1094 respondents. Validation tests showed that 68 % of eligible responses revealed consistent ordering of responses and 32 % displayed ordinal transitivity, while 37 % of respondents showing consistency and ordinal transitivity approached cardinal transitivity. Using consistent and ordinally transitive responses, the mean incremental cost per SAVE gained was £ 3.72 million. Further research is required to improve the validity of the SAVE, which may include a simpler web-based survey format or a face-to-face format to facilitate more informed responses. A validated method for estimating equivalent SAVEs is unlikely to replace the QALY as the globally preferred measure of outcome, but the SAVE may provide a useful alternative for localized decision makers with relatively small, constrained budgets-for example, in programme budgeting and marginal analysis.

US$19.90

PMID: 26100285

DOI: 10.1007/s40273-015-0308-5


Other references

Calder, E.E., 1922: New Cicindelas of the fulgida group (Coleop.). Canadian Entomologist, 54: 62

Christopher, J.A.; Doré, A.S.; Tehan, B.G., 2016: Potential for the Rational Design of Allosteric Modulators of Class C GPCRs. NlmCategory="UNASSIGNED">Class C G protein-coupled receptors encompass a range of promising therapeutic targets for a variety of diseases, yet to date only two members of this sub-family of GPCRs have been drugged. Recent advances in...

Willi, H.; Bischoff, A., 1961: On an unusual, familial, endogenousdegenerative leuko-encephalopathy of earliest infancy. Helvetica Paediatrica Acta 16: 391-411

Sangaré, L.; Manhart, L.; Zehrung, D.; Wang, C.C., 2009: Intradermal hepatitis B vaccination: a systematic review and meta-analysis. To compare seroprotection achieved by intradermal versus intramuscular hepatitis B vaccine, we conducted a systematic review of observational studies and a meta-analysis of randomized trials. Meta-analysis of data from 757 adults demonstrated that...

Karlsson L.; Roos C., 1984: Combination of liquid chromatography with uv detection and gas chromatography with electron capture detection for the determination of delta 9 tetra hydro cannabinol 11 oic acid in urine. [To detect the abuse of cannabis, sensitive and selective or specific analytic methods are needed for the determination of tetrahydrocannabinol and its metabolites in body fluids.] A method is described for the determination of .DELTA.9-tetrahydro...

Sherman R.T.; Lyons H., 1969: The biological fate of implanted rigid poly urethan foam marrow cavity rat tibia. Journal of Surgical Research 9(3): 167-171

Schleifenbaum, J.; Köhn, C.; Voblova, N.; Dubrovska, G.; Zavarirskaya, O.; Gloe, T.; Crean, C.S.; Luft, F.C.; Huang, Y.; Schubert, R.; Gollasch, M., 2010: Systemic peripheral artery relaxation by KCNQ channel openers and hydrogen sulfide. Perivascular adipose tissue secretes an adipocyte-derived relaxing factor (ADRF) that opens voltage-dependent K (Kv) channels in peripheral arteries. We studied the role of KCNQ-type Kv channels and tested the hypothesis that hydrogen sulfide (H2S...

Varga, J.; Lami, G., 1994: Remarks on the forensic veterinary medical judgement of fowl cholera. Most important aspects of the development of fowl cholera have briefly been reviewed and - based on these - conclusions have been drawn for the forensic veterinary medical judgement of the disease. After buying and selling day-old poultry flocks,...

Bahler, C.D.; Cary, K.Clint.; Garg, S.; DeRoo, E.M.; Tabib, C.H.; Kansal, J.K.; Monn, M.Francesca.; Flack, C.K.; Masterson, T.A.; Sandrasegaran, M.Kumar.; Foster, R.S.; Sundaram, C.P., 2016: Differentiating reconstructive techniques in partial nephrectomy: a propensity score analysis. To assess whether volumetric measurements can differentiate functional changes between reconstructive techniques after partial nephrectomy. One hundred and fifty-six patients undergoing partial nephrectomy for a single renal mass were retrospectiv...

Cabrera de León, A.; Almeida González, D.; González Hernández, A.; Domínguez Coello, S.; Marrugat, J.; Juan Alemán Sánchez, Jé.; Brito Díaz, B.; Marcelino Rodríguez, I.; Pérez, Mía.del.Cristo.Rodríguez., 2015: Relationships between serum resistin and fat intake, serum lipid concentrations and adiposity in the general population. The serum resistin level is associated with the incidence of ischemic heart disease in the general population. We analyzed the associations between serum resistin and fat intake, serum lipid concentrations and adiposity in the general population....