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Crude Aloe vera Gel Shows Antioxidant Propensities and Inhibits Pancreatic Lipase and Glucose Movement In Vitro

, : Crude Aloe vera Gel Shows Antioxidant Propensities and Inhibits Pancreatic Lipase and Glucose Movement In Vitro. Advances in Pharmacological Sciences 2016: 3720850-3720850

Aloe vera gel (AVG) is traditionally used in the management of diabetes, obesity, and infectious diseases. The present study aimed to investigate the inhibitory potential of AVG against α-amylase, α-glucosidase, and pancreatic lipase activity in vitro. Enzyme kinetic studies using Michaelis-Menten (K m ) and Lineweaver-Burk equations were used to establish the type of inhibition. The antioxidant capacity of AVG was evaluated for its ferric reducing power, 2-diphenyl-2-picrylhydrazyl hydrate scavenging ability, nitric oxide scavenging power, and xanthine oxidase inhibitory activity. The glucose entrapment ability, antimicrobial activity, and total phenolic, flavonoid, tannin, and anthocyanin content were also determined. AVG showed a significantly higher percentage inhibition (85.56 ± 0.91) of pancreatic lipase compared to Orlistat. AVG was found to increase the Michaelis-Menten constant and decreased the maximal velocity (V max) of lipase, indicating mixed inhibition. AVG considerably inhibits glucose movement across dialysis tubes and was comparable to Arabic gum. AVG was ineffective against the tested microorganisms. Total phenolic and flavonoid contents were 66.06 ± 1.14 (GAE)/mg and 60.95 ± 0.97 (RE)/mg, respectively. AVG also showed interesting antioxidant properties. The biological activity observed in this study tends to validate some of the traditional claims of AVG as a functional food.


PMID: 26880905

DOI: 10.1155/2016/3720850

Other references

de Strihou, v.Y., 1976: Complications Renales De L'Hypertension. High blood pressure has a deleterious effect on the kidney. It significantly modifies renal handling of water and electrolytes partially, at least, as a result of haemodynamic changes in the kidney. These disorders, which are observed only under c...

Larsen, A.K.agh; Filhol, O.; Cochet, C.; Chambaz, E.M.; Bojanowski, K., 1994: Association of topoisomerase II and casein kinase II in a molecular complex which is catalytically active. Journal of Cellular Biochemistry Supplement 0(18C): 102

Verchere, D.S.utereau, H.P.scault, J.; Moschiar, S.; Riccardi, C.; Williams, R., 1990: Rubber-modified epoxies. I. Influence of carboxyl-terminated butadiene-acrylonitrile random copolymers (CTBN) on the polymerization and phase separation processes. A bisphenol‐A diglycidylether (DGEBA) based epoxy was cured with a cycloaliphatic diamine (4,4′‐diamino‐3,3′‐dimethyldicyclohexylmethane, 3DCM), in the presence of an epoxy terminated butadiene‐acrylo...

Hliniak, A.; Tenner, J.; Wieckowski, B.; Galecki, W., 1964: Some Notes On The Role Of The P-32 Test In The Diagnosis Of Malignant Melanoma. Nowotwory 14: 341-344

Elderfield, R.C.; Gensler, W.J.; Birstein, O., 1946: Synthesis of 1-aminophenazines and conversion of them to potential antimalarials. Journal of Organic Chemistry 11(6): 812-822

Anahosur, K.H.; Patil, S.H., 1983: Effective spray schedule of metalaxyl (25 WP) for the sorghum downy mildew therapy. This fungicide at 2 g a.i./litre sprayed at 10 and 40 d or 20 and 50 d after emergence gave complete control of systemic infection by Peronosclerospora sorghi and increased grain yields.

Grabenwöger, F.; Bardach, G., 1983: Gas- and fluid-containing cavities in the small pelvis and their differential diagnosis. Since untreated intra-abdominal abscesses are associated with a high mortality rate, early diagnosis is important. In abscesses involving gas formation, plain radiographs of the abdomen in various projections are sufficient for diagnosis. In this...

Arikoglu, T.; Aslan, G.; Batmaz, S.Birgul.; Eskandari, G.; Helvaci, I.; Kuyucu, S., 2016: Diagnostic evaluation and risk factors for drug allergies in children: from clinical history to skin and challenge tests. Parent or self-reported drug allergy claims frequently overestimate the real incidence of hypersensitivity reactions. A detailed and algorithmic diagnostic evaluation of drug reactions may allow a proper diagnosis. The aim of this study was to det...

Payne, J.; Shibasaki, F.; Mercola, M., 1997: Spina bifida occulta in homozygous Patch mouse embryos. In normal embryos, mRNA encoding platelet-derived growth factor A (PDGF A) and the platelet-derived growth factor receptor alpha (PDGFR alpha) are found within and adjacent to the site of vertebral development, the sclerotome. These patterns of ex...

Ding, D.; Zhang, Y.; Liu, J., 2003: Some extensions of the Gaussian beam expansion: radiation fields of the rectangular and the elliptical transducer. A straightforward extension of Gaussian beam expansion is presented for calculation of the Fresnel field integral [J. J. Wen and M. A. Breazeale, J. Acoust. Soc. Am. 83, 1752-1756 (1988)]. The source distribution function is expanded into the supe...