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Current and Future Approaches to Target the Epidermal Growth Factor Receptor and Its Downstream Signaling in Metastatic Colorectal Cancer

, : Current and Future Approaches to Target the Epidermal Growth Factor Receptor and Its Downstream Signaling in Metastatic Colorectal Cancer. Clinical Colorectal Cancer 14(4): 203-218

The discovery of the key role of the epidermal growth factor receptor (EGFR) and its downstream signaling effectors in the pathophysiology of colorectal cancer (CRC) has ushered in the clinical use of targeted therapies in the treatment of metastatic CRC (mCRC). The anti-EGFR monoclonal antibodies cetuximab and panitumumab improve overall survival when combined with chemotherapy in first-line treatment of Kirsten rat sarcoma viral oncogene homolog (KRAS) and neuroblastoma RAS viral oncogene homolog (NRAS) wild type mCRC and also improve progression-free survival and response rate in first-line treatment and treatment of refractory mCRC. There are ongoing efforts to discover mechanisms of innate and acquired resistance to anti-EGFR therapies in KRAS wild type mCRC patients and to take therapeutic advantage of this knowledge by using rational combinations of targeted therapies. In this review we will discuss the evidence for current use of anti-EGFR therapies and several recent and ongoing investigations to refine treatment for KRAS wild type mCRC, including more complete inhibition of the EGFR, HER2 inhibition, and MET proto-oncogene, receptor tyrosine kinase (MET) inhibition.


PMID: 26077270

DOI: 10.1016/j.clcc.2015.05.006

Other references

Kim, H.; Boor, K.J.; Marquis, Hélène., 2004: Listeria monocytogenes sigmaB contributes to invasion of human intestinal epithelial cells. The role ofB in Listeria monocytogenes infection of human intestinal epitheliall cells was investigated. Invasion defects associated with loss of GB paralleled those of a DELTAinl4 strain independently of the sigmaB-dependent P2prfA promoter. Conc...

Febbraio, M.A.; Steensberg, A.; Fischer, C.P.; Keller, C.; Hiscock, N.; Pedersen, B.K.arlund, 2002: IL-6 activates HSP72 gene expression in human skeletal muscle. To determine whether the cytokine interleukin (IL)-6 induces heat shock protein (HSP) 72 gene expression in skeletal muscle, 18 healthy, young men had either a high dose of IL-6 (HiIL-6; n = 6), low dose IL-6 (LoIL-6; n = 6), or saline (CON; n = 6...

Punturieri, A.; Alviani, R.S.; Polak, T.; Copper, P.; Sonstein, J.; Curtis, J.L., 2004: Specific engagement of TLR4 or TLR3 does not lead to IFN-beta-mediated innate signal amplification and STAT1 phosphorylation in resident murine alveolar macrophages. The innate immune response must be mobilized promptly yet judiciously via TLRs to protect the lungs against pathogens. Stimulation of murine peritoneal macrophage (PMphi) TLR4 or TLR3 by pathogen-associated molecular patterns (PAMPs) typically ind...

Podor T.J.; Kumar S.; West D., 1984: Modulation of endothelial cell elastolytic activity by heparin and tumor angiogenesis factor. American Heart Association Monograph (107): II-71

Ohlmann, P.; Morel, O.; Radulescu, B.; Kindo, M.; Faure, A.; Billaud, P.; Petit, Hélène.; Meyer, N.; Jesel, L.; Desprez, D.; Mazzucotelli, J-Philippe.; Eisenmann, B.; Bareiss, P., 2008: D-Dimer in ruling out acute aortic dissection: sensitivity is not 100%. European Heart Journal 29(6): 828-9; Author Reply 829

Hurst, F.J.; Posey, F.A., 1982: Long-term potential of uranium recovery from H3PO4. [TVA].

Watanabe T.; Moran D.; E.T.mer E.; Staneloni L.; Salvaneschi J.; Altschuler N.; Degrossi O.J.; Niepominiszcze H., 1974: Iodized oil in the prophylaxis of endemic goiter in argentina. Pan American Health Organization Scientific Publication 292: 231-241

Monticelli, S., 1887: Osservazioni intorno ad alcuue specie di Acantocefali. Regards the Echinorhynchus ruber of Collett as identical with E. turbinella; notes on other species.

Birocale, A.Marcos.; Medeiros, A.Raquel.Santos.; Ruffoni, L.Dias.Gonçalves.; Takayama, L.; de Oliveira, Jé.Martins.; Nonaka, K.Okino.; Pereira, R.Maria.Rodrigues.; Bissoli, Né.Souza., 2016: Bone mineral density is reduced by telmisartan in male spontaneously hypertensive rats. Telmisartan, an angiotensin AT1 receptor blocker, and treadmill running were compared for their effects on bone mineral density (BMD) and biomechanical properties of male spontaneously hypertensive rats (SHR). It was hypothesized that running (18m...

Wang, C-Ta.; Chou, W-Lung.; Kuo, Y-Ming., 2008: Removal of COD from laundry wastewater by electrocoagulation/electroflotation. The removal efficiency of COD in the treatment of simulated laundry wastewater using electrocoagulation/electroflotation technology is described. The experimental results showed that the removal efficiency was better, reaching to about 62%, when a...