geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Current insights into the molecular mechanisms of hypoxic pre- and postconditioning using hypobaric hypoxia


, : Current insights into the molecular mechanisms of hypoxic pre- and postconditioning using hypobaric hypoxia. Frontiers in Neuroscience 9: 388-388

Exposure of organisms to repetitive mild hypoxia results in development of brain hypoxic/ischemic tolerance and cross-tolerance to injurious factors of a psycho-emotional nature. Such preconditioning by mild hypobaric hypoxia functions as a "warning" signal which prepares an organism, and in particular the brain, to subsequent more harmful conditions. The endogenous defense processes which are mobilized by hypoxic preconditioning and result in development of brain tolerance are based on evolutionarily acquired gene-determined mechanisms of adaptation and neuroprotection. They involve an activation of intracellular cascades including kinases, transcription factors and changes in expression of multiple regulatory proteins in susceptible areas of the brain. On the other hand they lead to multilevel modifications of the hypothalamic-pituitary-adrenal endocrine axis regulating various functions in the organism. All these components are engaged sequentially in the initiation, induction and expression of hypoxia-induced tolerance. A special role belongs to the epigenetic regulation of gene expression, in particular of histone acetylation leading to changes in chromatin structure which ensure access of pro-adaptive transcription factors activated by preconditioning to the promoters of target genes. Mechanisms of another, relatively novel, neuroprotective phenomenon termed hypoxic postconditioning (an application of mild hypoxic episodes after severe insults) are still largely unknown but according to recent data they involve apoptosis-related proteins, hypoxia-inducible factor and neurotrophins. The fundamental data accumulated to date and discussed in this review open new avenues for elaboration of the effective therapeutic applications of hypoxic pre- and postconditioning.

US$19.90

PMID: 26557049

DOI: 10.3389/fnins.2015.00388


Other references

Hartman, A.A.; Nicolay, R.C.; Hurley, J., 1968: Unique personal names as a social adjustment factor. Journal of Social Psychology 75(1): 107-110

Hauer, K.E.; Boscardin, C.; Fulton, T.B.; Lucey, C.; Oza, S.; Teherani, A., 2016: Using a Curricular Vision to Define Entrustable Professional Activities for Medical Student Assessment. The new UCSF Bridges Curriculum aims to prepare students to succeed in today's health care system while simultaneously improving it. Curriculum redesign requires assessment strategies that ensure that graduates achieve competence in enduring...

Yilmaz, S.; Karakayali, O.; Kale, E.; Akdogan, A., 2017: Could serum S100B be a predictor of neuronal damage and clinical poor outcomes associated with the use of synthetic cannabinoids? S100B to predict neuronal damage of SC in the ED. This study aims to evaluate the serum S100B levels to predict neuronal damage and poor clinical outcomes associated with the use of synthetic cannabinoids. Thirty patients identified as synthetic cannabinoid users and 30 healthy controls were incl...

Angermann, H.; Rossler, E., 1975: Efficiency criteria in livestock production. In order to analyze the factors which influence the profitability of livestock production, factor analyses were carried out in 40 pig fattening farms, 23 cattle fattening farms, 32 beef cattle rearing farms and 38 dairy cattle farms. The variance...

Rosalbino, F.; Macciò, D.; Scavino, G.; Saccone, A., 2012: In vitro corrosion behaviour of Ti-Nb-Sn shape memory alloys in Ringer's physiological solution. The nearly equiatomic Ni-Ti alloy (Nitinol) has been widely employed in the medical and dental fields owing to its shape memory or superelastic properties. The main concern about the use of this alloy derives form the fact that it contains a large...

Komiya, Y., 1964: The prevention of schistosomiasis japonica. Work on the prevention of Schistosoma japonicum infection in man in Japan both before and after the discovery of the vector snail, Oncomelania nosophora, is reviewed. There are 165 references.

Guo, X.; Zhao, Z.; Chen, J.; Hu, X.; Luo, D., 2006: A putative CENTRORADIALIS/TERMINAL FLOWER 1-like gene, Ljcen1, plays a role in phase transition in Lotus japonicus. CENTRORADIALIS/TERMINAL FLOWER 1 (CEN/TFL1) genes play an important role in the phase transition of plant flowering. Here we characterized the expression pattern of a CEN/TFL1-like gene, Ljcen1, from Lotus japonicus. Sequence analysis revealed tha...

Erice, A.; Sannerud, K.J.; Mayers, D.L.; Balfour, H.H.Jr, 1994: Variable phenotypic expression of zidovudine resistant genotypes of human immunodeficiency virus type 1 in susceptibility assays. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 34(0): 233

Jensen, N.Koitzsch.; Nielsen, S.Smith.; Krasnik, A., 2010: Expert opinion on "best practices" in the delivery of health care services to immigrants in Denmark. Delivery of health care to immigrants is an emerging field of interest. Immigrants are frequently characterised by health outcomes that are inferior to those of other groups with regard to morbidity and mortality. In addition, health professionals...

Bass Nathan Wood, 1946: Geological Survey completes new structure map for Rangely field. Oil and Gas Journal 45(30): 86-87