geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Decreased expression of BRCA1-associated protein 1 predicts unfavorable survival in gastric adenocarcinoma


, : Decreased expression of BRCA1-associated protein 1 predicts unfavorable survival in gastric adenocarcinoma. Tumour Biology 37(5): 6125-6133

BRCA1-associated protein 1 (BAP1) has been reported as a novel tumor suppressor, while in gastric adenocarcinoma, the function of this protein was still await to be uncovered. Based on a large group of patients with gastric adenocarcinoma, our study aimed to have a further understanding about the correlation of BAP1 expression and patients' clinical outcomes. We performed quantitative PCR and Western blot to examine BAP1 expression in 38 cases of gastric adenocarcinoma samples and adjacent non-cancerous tissues. Immunochemistry was used to evaluate BAP1 expression in a large cohort of 474 paraffin-embedded specimens. The clinical and prognostic significance of BAP1 expression was statistically analyzed. Postoperative survival between groups was using Kaplan-Meier analysis. BAP1 was overexpressed in paracancerous normal mucosa compared with gastric cancer. Decreased BAP1 expression was associated with higher histologic grade (P = 0.044), tumor infiltration (P < 0.001), metastasis status (P = 0.023), and TNM stage (P < 0.001). Patients with low expression of BAP1 had shorter overall survival compared with those with high expression (P < 0.001). Patients' survival in stage N0 could be stratified by the expression of BAP1. Multivariate analysis showed that in gastric adenocarcinoma, BAP1 expressing level was an independent prognostic factor (RR = 0.575, P < 0.001). Decreased expression of BAP1 suggests pessimistic prognosis for gastric adenocarcinoma patients. Further studies are warranted.

US$19.90

PMID: 26611647

DOI: 10.1007/s13277-015-3983-0


Other references

Henriksen, T.H.; Brorson, O.; Schöyen, R.; Thoresen, T.; Setegn, D.; Madebo, T., 1995: Rapid growth of Helicobacter pylori. The ability of six variants of a new charcoal medium and Skirrow's medium to grow Helicobacter pylori in 3 and 5 days was studied using 20 different strains of Helicobacter pylori. The main admixtures for the charcoal media were serum, whole...

Schena, F.P., 2012: Management of patients with chronic kidney disease. Chronic kidney disease (CKD) is a silent disease which worsens gradually to end-stage kidney disease (ESKD). US kidney disease outcomes quality initiative (KDOQI) guidelines indicate five stages of CKD based on the severity of kidney function whic...

O.J.T.; Baron L.S.; Rubin F.A.; Kopecko D.J., 1987: Specific insertion and deletion of an is1 like dna element is the controlling mechanism for reversible expression of the vi antigen in enteric bacteria. Plasmid 17(1): 77

Zaets, T.L.; Borisova, T.A., 1965: Changes in protein metabolism in experimental burns during the action of chlorpromazine. Healthy rabbits and those with burns were used to study the autolytic activity of the tissues, the level of nucleic acids within them, and incorporation of S35-methionine in protein following administration of chlorpromazine. Chlorpromazine does n...

Phillips, P.; Denman, A.; Gillmore, G., 2000: Radon, schools and health: implications for policy and practice of a comparative study of programmes in Poland and the UK. Two radon in-schools programmes are compared in markedly different regions in an attempt to determine issues of policy and practice that require further research. The Northamptonshire programme was part of a mature UK programme, driven by enforced...

Chudoba, S., 1930: Appareil de Golgi, vacuome et chondriome pendant la spermatogenese de Dytiscus marginalis L Coleoptere. Compte Rendu des Seances de la Societe de Biologie Paris, 104: 1094-1095

Foguet, J.; Oste, C.; Alvarez, S.G.nzalez, J.; Delfini, A., 1977: Growth, yield and fruit quality of Eureka lemon on nine rootstocks. Revista industrial y agricola de Tucuman: 4 (1) 17-27

Khotib, J.; Narita, M.; Suzuki, M.; Yajima, Y.; Suzuki, T., 2004: Functional interaction among opioid receptor types: up-regulation of mu- and delta-opioid receptor functions after repeated stimulation of kappa-opioid receptors. It has been widely accepted that repeated administration of kappa-opioid receptor agonists leads to the development of antinociceptive tolerance. The present study was designed to investigate the effect of repeated administration of a selective ka...

Mochizuki, Y.; Tanaka, H.; Matsumoto, K.; Sano, H.; Shimoura, H.; Ooka, J.; Sawa, T.; Ryo-Koriyama, K.; Hirota, Y.; Ogawa, W.; Hirata, K-Ichi., 2016: Impaired Mechanics of Left Ventriculo-Atrial Coupling in Patients With Diabetic Nephropathy. Diabetic nephropathy is independently associated with longitudinal systolic dysfunction of the left ventricle (LV) in asymptomatic diabetes mellitus (DM) patients with preserved LV ejection fraction (LVEF). However, the effect of diabetic nephropa...

Read J.F.ed; Wynn Thomas C., 2006: Carbon-oxygen isotope signal of Mississippian slope carbonates, Appalachians, USA; a complex response to climate driven fourth order glacio-eustasy. Mississippian ramp slope muds, Virginia were not significantly reset isotopically by meteoric aquifer systems, because of their location in a rapidly subsiding foreland basin. The carbon and oxygen isotopes tend to covary with negative excursions...