+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Dehydroepiandrosterone alters vitamin E status and prevents lipid peroxidation in vitamin E-deficient rats

, : Dehydroepiandrosterone alters vitamin E status and prevents lipid peroxidation in vitamin E-deficient rats. Journal of Clinical Biochemistry and Nutrition 58(3): 223-231

In humans, dehydroepiandrosterone and its sulfate ester metabolite DHEA-S are secreted predominantly from the adrenal cortex, and dehydroepiandrosterone is converted to steroid hormones, including androgens and estrogens, and neurosteroid. Dehydroepiandrosterone exerts protective effects against several pathological conditions. Although there are reports on the association between dehydroepiandrosterone and vitamins, the exact relationship between dehydroepiandrosterone and vitamin E remains to be determined. Therefore, we attempted to elucidate the effect of dehydroepiandrosterone on vitamin E status and the expression of various vitamin E-related proteins, including binding proteins, transporters, and cytochrome P450, in vitamin E-deficient rats. Plasma α-tocopherol levels in vitamin E-deficient rats increased in response to dehydroepiandrosterone administration. The expression of hepatic α-tocopherol transfer protein was repressed in vitamin E-deficient rats compared to that in control rats; however, dehydroepiandrosterone administration significantly upregulated this expression. Hepatic expression of CYP4F2, an α-tocopherol metabolizing enzyme, in vitamin E-deficient rats was decreased by dehydroepiandrosterone administration, whereas hepatic expression of ATP-binding cassette transporter A1, an α-tocopherol transporter, was not altered following dehydroepiandrosterone administration. Dehydroepiandrosterone repressed lipid peroxidation in the liver of vitamin E-deficient rats. Therefore, adequate dehydroepiandrosterone supplementation may improve lipid peroxidation under several pathological conditions, and dehydroepiandrosterone may modulate α-tocopherol levels through altered expression of vitamin E-related proteins.


PMID: 27257348

DOI: 10.3164/jcbn.15-133

Other references

Dunstall, K., 1986: In poor health. New Zealand Nursing Journal. Kai Tiaki 79(10): 11-15

Dangy, B., 1976: The first permanent molar in orthodontic practice. Cahiers D'odonto-Stomatologie 8(3): 13-16

Dósa, G.; Kiss, G.; Fráter, L.; Varga, E., 1987: Management of pseudoarthrosis of the carpal navicular bone using Ender's small plate. Magyar Traumatologia, Orthopaedia Es Helyreallito Sebeszet 30(4): 247-250

Hirata, K.; Katayama, S.; Yamazaki, K.; Fujikane, M.; Ichimaru, Y., 1996: Efficacy of nefiracetam in dementia A study using event-related potentials. Ogura, C , Koga, Y , Shimokochi, M International Congress Series; Recent advances in event-related brain potential research 625-632

Munson, R.J.; Bridges, B.A., 1973: The LET factor in mutagenesis by ionizing radiations. I. Reversion to wild type of a bacteriophage T4 amber mutant. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine 24(3): 257-273

Yeager, J.Franklin, 1938: Mechanographic method of recording insect cardiac activity, with reference to effect of nicotine on isolated heart preparations of Periplaneta americana. An improved photographic method of obtaining mechano-grams from the insect heart, in isolated prepn., is descr. The mechanograms are of sufficient size and clarity to be submitted to analysis and to show the changes in mechanical activity of the h...

D.Tomasi, A., 1926: A transparent milk as culture medium. One may prepare from milk a good, fluid, transparent nutrient medium that coagulates either with acid or rennet. Skimmed sterile, heated milk is made alkaline with Na2 CO3 and NaCl. It is shaken with ethyl ether and filtered into sterile flasks. C...

Shaw, D.; Chappel, W.D.; Goldman, B.D., 1993: Effect of prenatal photoperiod on reproductive development in Siberian hamster. Society for Neuroscience Abstracts 19(1-3): 1561

Higashi, S., 1983: Polygyny and nuptial flight of Formica (Formica) yessensis Forel at Ishikari Coast, Hokkaido, Japan. The vertical distribution of queens and workers in a supercolony of Formica yessensis Forel on the Ishikara Coast of Hokkaido, Japan, fluctuated seasonally. All the queens in a nest tended to assemble in the same rooms without hostility. Inseminat...

Bergman, A.B.; Bechwith, J.B.; Ray, C.G., 1975: The apnea monitor business. Because of the unique age distribution of sudden infant death syndrome [SIDS], investigators are now quite logically focusing their studies on many types of physiologic variability in the 1-4 mo. age group. More specifically, attention is being gi...