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Delayed dopamine signaling of energy level builds appetitive long-term memory in Drosophila


, : Delayed dopamine signaling of energy level builds appetitive long-term memory in Drosophila. Cell Reports 10(7): 1023-1031

Sensory cues relevant to a food source, such as odors, can be associated with post-ingestion signals related either to food energetic value or toxicity. Despite numerous behavioral studies, a global understanding of the mechanisms underlying these long delay associations remains out of reach. Here, we demonstrate in Drosophila that the long-term association between an odor and a nutritious sugar depends on delayed post-ingestion signaling of energy level. We show at the neural circuit level that the activity of two pairs of dopaminergic neurons is necessary and sufficient to signal energy level to the olfactory memory center. Accordingly, we have identified in these dopaminergic neurons a delayed calcium trace that correlates with appetitive long-term memory formation. Altogether, these findings demonstrate that the Drosophila brain remembers food quality through a two-step mechanism that consists of the integration of olfactory and gustatory sensory information and then post-ingestion energetic value.

US$19.90

PMID: 25704807

DOI: 10.1016/j.celrep.2015.01.036


Other references

Waldmann, T.A., 1992: Immune receptors: targets for therapy of leukemia/lymphoma, autoimmune diseases and for the prevention of allograft rejection. Immune receptor-directed therapy has been applied clinically to an array of human disorders. However, effective therapy using unmodified murine monoclonal antibodies was elusive because these antibodies are immunogenic and elicit a human immune re...

Hsieh, S.C., 1972: Agricultural development in Asia - problems and strategies. Part I. Asian agriculture is characterized by lack of infrastructure, particularly flood controls, communication and marketing. The new technology cannot, therefore, be effectively applied in many cases. Adoption of new techniques is often also hampered b...

Tammali, R.; Ramana, K.V.; Singhal, S.S.; Awasthi, S.; Srivastava, S.K., 2006: Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells. Inhibition of prostaglandin E-2 (PGE(2)) and cyclooxygenase (COX)-2 by nonsteroidal anti-inflammatory drugs reduces the progression of colon cancer. Inhibition of aldose reductase (AR; EC. 1.1.1.21.) by sorbinil or by antisense ablation prevented...

Ozbun, J.L.; Volk, R.J.; Jackson, W.A., 1965: Effect of potassium deficiency on photosynthesis, respiration and the utilization of photosynthetic reductant by immature bean leaves. Gas-exchange rates of immature leaflets excised from normal and K-deficient bean plants (Phaseolus vulgaris) were determined in light and darkness using mass spectrometric techniques. Labeled oxygen, 02 18, and carbon dioxide, C13O2,were utilized...

Fujita T., 1987: A molecular modeling based upon an x ray crystal structure the enzyme ligand complexes between porcine pancreatic elastase and acetyl alanine alanine glycine alanine. Molecular models of the complexes betweeen porcine pancreatic elastase (PPE, EC 3.4.4.7), and acetyl-alanine-alanine-alanine (AAA) and acetyl-alanine-glycine-alanine (AGA) are constructed by means of molecular mechanics (MM) calculation, based upo...

Mateo A.; Teijeiro J.; Carreras J.L.; Garcia F.; Banzo J.; Abos M.D.; Banzo I., 1978: Detection of bone metastases with technetium 99m phosphate complexes semiology. Oncologia (Madrid) 3(4): 132-142

Maksimak, M.; Ament, M.E.; Fonkalsrud, E.W., 1982: Comparison of the pediatric Broviac silastic catheter with a standard no. 3 French silastic catheter for central venous alimentation. Two No. 3 French silastic central venous catheters designed for infants, a pediatric Broviac catheter, and a standard infant catheter were used in 41 (group I) and 33 infants (group II), respectively, to compare the effectiveness of each in provid...

Boulegue J.; Jedwah J., 1985: Deep-sea hydrothermal activity, East Pacific Rise at 13 degrees N. Comptes-Rendus des Seances de l'Academie des Sciences, Serie 2: Mecanique-Physique, Chimie, Sciences de l'Univers, Sciences de la Terre 300(7): 273-276

Chandana, S.; Mahadevan, D., 2010: Translational advances and novel therapies for pancreatic ductal adenocarcinoma: hope or hype?. Biological complexity, inaccessible anatomical location, nonspecific symptoms, lack of a screening biomarker, advanced disease at presentation and drug resistance epitomise pancreatic ductal adenocarcinoma (PDA) as a poor-prognosis, lethal disease...

Beasley, TM.; Heyraud, M.; Higgo, JJW.; Cherry, RD.; Fowler, SW., 1978: 210Po and 210Pb in zooplankton fecal pellets. 210Po and 210Pb concentrations in fecal pellets from the zooplanktonic euphausiid Meganyctiphanes norvegica are reported. The 210Po:210Pb activity ratio is 2.2 .+-. 0.3, a value in agreement with that found in suspended particulate matter in surfa...