+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Depression and hypomania symptoms are associated with high dose corticosteroids treatment for MS relapses

, : Depression and hypomania symptoms are associated with high dose corticosteroids treatment for MS relapses. Journal of Affective Disorders 187(): 142-146

Psychiatric side effects are known to occur with low dose corticosteroids. Standard of care for Multiple Sclerosis (MS) relapses is high dose corticosteroids (HDC), at least 1g/day for 3-5 days, and yet the relationship between this treatment and mood is not known. We sought to determine the frequency and potential predictors of (hypo)manic and depressive symptoms with HDC treatment for MS relapses. Consecutive MS subjects requiring HDC treatment were identified. The Mood Disorders Questionnaire (MDQ) and the Beck Depression Inventory-Fast Screen (BDIFS) were administered for (hypo)manic and depressive symptoms, respectively, prior to HDC, 3 days and one month post-HDC. Eighty eight subjects completed the study. At relapse diagnosis, the mean BDIFS score was 4.2 (SD 3.1); the mean number of (hypo)manic symptoms endorsed on the MDQ was 4.3 (SD 3.5). Three days after completing HDC, 22.5% had an increase on the BDIFS and 38.2% endorsed more symptoms on the MDQ. A history of depression (p=0.006) and low reported quality of life (p=0.029) predicted an increase on the MDQ; the odds of an increase in (hypo)manic symptoms was 5.6 times higher with a history of any psychiatric disease/substance abuse (p=0.005). No predictors for worsening on the BDIFS were found. Self-reported measures were used, anxiety was not evaluated and 17 subjects were lost to follow up. Depressive and hypo(manic) symptoms are commonly associated with HDC for MS relapses. It is important for clinicians and MS patients to be aware of this risk.


PMID: 26334182

DOI: 10.1016/j.jad.2015.08.040

Other references

von Rohden, C.; Ilmberger, J.; Boehrer, B., 2009: Assessing ground water coupling and vertical exchange in a meromictic mining lake with an SF6 tracer experiment. Groundwater-lake interaction in conjunction with surface mixing and vertical exchange were quantitatively examined for the monimolimnion in a small stratified mining lake. Although the lake is shallow ( approximately 4.7 m), it shows a strong mero...

Kales A.; Preston T.A.; Slye E.I.; Bixler E.O., 1972: Sleep patterns of insomniac subjects further studies. Psychophysiology 9(1): 137

Perry Eugene Sheridan; Cooke Strathmore Ridley Barnott, 1946: Spectrographic prospecting for beryllium in pegmatites of western Montana. American Mineralogist 31(9-10): 499-502

Gray, D.G.; White, R.; Russell, F.; Cooper, P.J., 2002: Secondary wound dressings: an evaluation of Alldress. Nurses are increasingly faced with the need to balance clinical efficacy with economic advantages when selecting wound management products. Compared to 20 or 30 years ago the money spent by the NHS in the UK on wound dressings has risen dramatical...

Amir, I.; Gurion, Y.; Dalins, B., 1989: Trade-off of resources in regional agricultural production. The agricultural production of a region is planned using two successive linear programming (LP) models: (a) the family farm model (FFM), for which the objective function is to minimize capital investments provided that a predetermined annual net i...

Higashi, T.; Baba, S.; Kakuta, H., 2004: A three-dimensional model of fish schooling behavior. A model of fish schooling behavior in a three-dimensional coordinate frame is proposed, drawing from observed fish behavior and theoretical behavior domains. Although fish schooling has been studied extensively, most models are based on a two-dime...

Poghosyan, T.; Gaujoux, S.; Sfeir, R.; Larghero, J.; Cattan, P., 2011: Bioartificial oesophagus in the era of tissue engineering. Journal of Pediatric Gastroenterology and Nutrition 52 Suppl 1: S16-S17

Lowe, A-Marie., 2016: Once again Lyme disease. Perspective Infirmiere 12(5): 44-46

Wilde, D.W.; Furspan, P.B.; Szocik, J.F., 1994: Calcium current in smooth muscle cells from normotensive and genetically hypertensive rats. Genetic hypertension results from numerous phenotypic expressions. We hypothesized that increased calcium current in vascular smooth muscle of genetically hypertensive animals is partly responsible for observed increases in agonist sensitivity, co...

Weber H.W.; Schultz L., 1978: Noble gases in 10 stony meteorites from Antarctica and their exposure ages. Meteoritics 13(4): 658-660