geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Development and experimental design of a novel controlled-release matrix tablet formulation for indapamide hemihydrate


, : Development and experimental design of a novel controlled-release matrix tablet formulation for indapamide hemihydrate. Pharmaceutical Development and Technology (): 1-9

Development, experimental design and in vitro in vivo correlation (IVIVC) of controlled-release matrix formulation. Development of novel oral controlled delivery system for indapamide hemihydrate, optimization of the formulation by experimental design and evaluation regarding IVIVC on a pilot scale batch as a confirmation of a well-established formulation. In vitro dissolution profiles of controlled-release tablets of indapamide hemihydrate from four different matrices had been evaluated in comparison to the originator's product Natrilix (Servier) as a direction for further development and optimization of a hydroxyethylcellulose-based matrix controlled-release formulation. A central composite factorial design had been applied for the optimization of a chosen controlled-release tablet formulation. The controlled-release tablets with appropriate physical and technological properties had been obtained with a matrix: binder concentration variations in the range: 20-40w/w% for the matrix and 1-3w/w% for the binder. The experimental design had defined the design space for the formulation and was prerequisite for extraction of a particular formulation that would be a subject for transfer on pilot scale and IVIV correlation. The release model of the optimized formulation has shown best fit to the zero order kinetics depicted with the Hixson-Crowell erosion-dependent mechanism of release. Level A correlation was obtained.

US$19.90

PMID: 26402027

DOI: 10.3109/10837450.2015.1089898


Other references

Kamemoto, H., 1952: Further studies on polyploid Cattleyas. Chromosome numbers were established for several horticultural vars. of orchids belonging to the Cattleya group. Twelve diploids (2n = 40), 17 triploids (2n = ca. 60), and 26 tetraploids (2n = ca. 80) were recorded. Triploid and tetraploid vars. ar...

Gol'din, L.S., 1968: Submicroscopic organisation of the cerebellar cortex cells in the rat. Tsitologiia 10(6): 675-683

Bubenik, G.A.; Miller, K.V.; Lister, A.L.; Osborn, D.A.; Bartos, L.; Van Der Kraak, G.J., 2005: Testosterone and estradiol concentrations in serum, velvet skin, and male white-tailed deer. The growth and mineralization of antlers correlate with the seasonal variation of serum androgens. Whereas seasonal levels of testosterone (T) in plasma are well established, steroid concentrations have not yet been determined in the tissues of gr...

Lee, J.; Kim, Y-Seong.; Choi, D-Hee.; Bang, M.Suk.; Han, T.Ryoon.; Joh, T.H.; Kim, S-Youl., 2004: Transglutaminase 2 induces nuclear factor-kappaB activation via a novel pathway in BV-2 microglia. Transglutaminase 2 (TGase 2) expression is increased in inflammatory diseases. We demonstrated previously that inhibitors of TGase 2 reduce nitric oxide ( NO) generation in a lipopolysaccharide (LPS)-treated microglial cell line. However, the prec...

Oesterreich, L.S.irer, K., 1992: Understanding abuse: transform addictive work patterns. PM Iowa State University Cooperative Extension Service: 92 (1478-14)

Clarke, H.J.; Carroll, J.; Mclay, D.W., 2001: The ability of murine oocytes to assemble histones onto sperm chromatin is acquired coincident with meiotic competence and may involve Ca2+-regulated mechanisms. Biology of Reproduction 64(Supplement 1): 294-295

Dierckx, E.; Engelborghs, S.; D.R.edt, R.; D.D.yn, P.P.; Ponjaert-Kristoffersen, I., 2006: Differentiation between mild cognitive impairment, Alzheimer's disease and depression by means of cued recall. Discriminating Alzheimer's disease (AD) and mild cognitive impairment (MCI) from depression is a challenge in psychogeriatric medicine. A study was set up to ascertain whether cued recall could be useful in differentiating early AD and MCI fr...

Diachenko, V.V., 1997: The use of x-ray contrast methods in the differential diagnosis of the causes of ascites. Transcutaneous transhepatic lymphography was conducted in 116 patients with hepatic cirrhosis 127 times in total to study up the type of plasma flow. An inguinal nodulolymphography was performed additionally in several patients. Peripheral type of...

Saugstad, L.F., 1980: Birth weight of children with phenylketonuria. Pediatrics 65(1): 190-192

Bailey, J.S.; Buhr, R.J.; Cox, N.A.; Berrang, M.E., 1994: Prevention of Salmonella cross-contamination in hatching cabinets. Poultry Science 73(SUPPL 1): 102