geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Development of Pancreatic Cancer, Disease-specific Mortality, and All-Cause Mortality in Patients with Nonresected IPMNs: A Long-term Cohort Study


, : Development of Pancreatic Cancer, Disease-specific Mortality, and All-Cause Mortality in Patients with Nonresected IPMNs: A Long-term Cohort Study. Radiology 278(1): 125-134

To determine the cumulative incidence, disease-specific mortality, and all-cause mortality of pancreatic cancer (PC) in patients with intraductal papillary mucinous neoplasms (IPMNs) and to identify imaging findings that are associated with these outcomes. This retrospective study had institutional review board approval, and the need to obtain patient consent was waived. Data from an electronic database were analyzed and supplemented by chart reviews for 285 patients with nonresected IPMNs who were periodically followed up with imaging (1273 multidetector computed tomography and 750 magnetic resonance cholangiopancreatography examinations). The Kaplan-Meier method was used to estimate the cumulative development of PC, PC mortality, and all-cause mortality (factors were compared by using the log-rank test). Over a median imaging follow-up period of 39 months, 12 (4.2%) of 285 patients developed PC; the cumulative 5-year PC incidence was 3.9% for branch duct (BD)-IPMNs, 45.5% for main duct (MD)-IPMNs (P < .01), 7.7% for cysts 30 mm or larger, and 5.3% for cysts smaller than 30 mm (P = .82). Over a median survival follow-up period of 47.5 months, seven (2.5%) of 285 patients died of PC and 14 (4.9%) patients died of other causes. Cumulative 5-year PC mortality was 2.1% for BD-IPMNs, 18.5% for MD-IPMNs (P < .01), 2.6% for cysts 30 mm or larger, and 2.8% for cysts smaller than 30 mm (P = .90). Cumulative 5-year all-cause mortality was 5.5% for BD-IPMNs, 18.5% for MD-IPMNs (P < .01), 12.5% for cysts 30 mm or larger, and 5.9% for cysts smaller than 30 mm (P = .89). Five-year PC development, disease-specific mortality, and all-cause mortality were approximately 4%, 2%, and 6% for BD-IPMNs and 46%, 19%, and 19% for MD-IPMNs, respectively. The presence of an MD-IPMN, but not cyst size, was significantly associated with PC development and subsequent mortality.

US$19.90

PMID: 26172534

DOI: 10.1148/radiol.2015150131


Other references

Debari V.A.; Cruz R.A.; Needle M.A.; Bennun A., 1985: Dinucleotide oxidation by the fenton reaction. Federation Proceedings 44(4): 922

Chan, Y.K., 1997: Performance and stability of pineapple hybrids in G x E trials in Malaysia. Six promising hybrids developed from a hybridization programme ar MARDI were evaluated in 3 environments (drought, peat and mineral soil) in Malaysia together with 2 control varieties. The peat environment was favourable for development of suckers...

Yang; Wang; Cho; Kishimoto; Hashizume; Sakurai, 1995: Superstructures of the Pb/Ge(001) system. Physical Review. B, Condensed Matter 51(12): 7571-7582

Middleton, P.; Crowther, C.A.; Simmonds, L., 2016: Different intensities of glycaemic control for pregnant women with pre-existing diabetes. The optimal glycaemic control target in pregnant women with pre-existing diabetes is unclear, although there is a clear link between high glucose concentrations and adverse birth outcomes. To assess the effects of different intensities of glycaemi...

Gheissari, A.; Naseri, F.; Pourseirafi, H.; Merrikhi, A., 2012: Postnatal kidney function in children born very low birth weight. There are scarce data on estimating the time of completing kidney maturation in very-low-birth-weight (VLBW) infants. The aim of this study was to determine whether different aspects of kidney function differ between VLBW infants and normal babies...

Shen, S-C., 1971: A new genus of clinid fishes from the Indo-west-Pacific, with a redescription of Clinus nematopterus. Copeia, 697-707

Ghosh, S.; Dorsey, F.C.; Cox, J.V., 2000: Casein kinase II A regulator of Ank1 and Ank3 function. Molecular Biology of the Cell 11(Supplement): 386a, Dec

Srivastava; Klooster; Koetzle, 2000: Neutron structures of ammonium tetrafluoroberyllate. It is thought that hydrogen bonding is responsible for the ferroelectricity in ammonium tetrafluoroberyllate, (NH(4))(2)BeF(4). In the past X-ray data have been collected, but these did not permit accurate determination of the H-atom positions. In...

Makarov, F.N.; Granstrem, E.E.; Markova, L.A., 2000: A morphological analysis of the cluster organization of the cortico-cortical neurons in area 17 of the cat visual cortex. Spatial organisation and quantitative features of cortico-cortical neurons in area 17 that project to area 21a of cat visual cortex were investigated. We used the HRP technique and two-dimensional reconstruction from serial sections of brain. Patt...

Demek J., 1980: The geographical prognosis in present-day Czech geography. Sbornik Ceskoslovenske Geograficke Spolecnosti 85(1): 3-8