geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Differential effects of mineralocorticoid and angiotensin II on incentive and mesolimbic activity


, : Differential effects of mineralocorticoid and angiotensin II on incentive and mesolimbic activity. Hormones and Behavior 79: 28-36

The controls of thirst and sodium appetite are mediated in part by the hormones aldosterone and angiotensin II (AngII). The present study examined the behavioral and neural mechanisms of altered effort-value in animals treated with systemic mineralocorticoids, intracerebroventricular AngII, or both. First, rats treated with mineralocorticoid and AngII were tested in the progressive ratio operant task. The willingness to work for sodium versus water depended on hormonal treatment. In particular, rats treated with both mineralocorticoid and AngII preferentially worked for access to sodium versus water compared with rats given only one of these hormones. Second, components of the mesolimbic dopamine pathway were examined for modulation by mineralocorticoids and AngII. Based on cFos immunohistochemistry, AngII treatment activated neurons in the ventral tegmental area and nucleus accumbens, with no enhancement by mineralocorticoid pretreatment. In contrast, Western blot analysis revealed that combined hormone treatment increased levels of phospho-tyrosine hydroxylase in the ventral tegmental area. Thus, mineralocorticoid and AngII treatments differentially engaged the mesolimbic pathway based on tyrosine hydroxylase levels versus cFos activation.

US$19.90

PMID: 26730722

DOI: 10.1016/j.yhbeh.2015.12.002


Other references

Sharif, N.R.; Dar, A.A., 1996: Stochastic frontiers and technical efficiency distributions: an analysis based on rice farming data for Bangladesh. A sample of farmers from Bangladesh is examined to study inter and intra crop patterns of technical efficiency in rice cultivation by estimating stochastic production frontiers, as well as to assess the role of household endowments and other chara...

Katzenstein, A.L.; Gordon, L.P.; Oliphant, M.; Swender, P.T., 1995: Chronic pneumonitis of infancy. A unique form of interstitial lung disease occurring in early childhood. We describe nine infants with a rare form of interstitial lung disease that is characterized by marked alveolar septal thickening, striking alveolar pneumocyte hyperplasia, and an alveolar exudate containing numerous macrophages and foci of eosino...

Menzies R.A.; Rier S.E.; Hall N.R.S.; O'grady M.P.; Oliver J., 1991: Recombinant interferon alpha inhibits opioid ligand binding to brain membranes. Society for Neuroscience Abstracts 17(1-2): 831

Hrdy, I., 1976: The influence of juvenile hormone analogues on caste development in termites. 71. Unknown

Hughes, D.W.; Galau, G.A., 1987: Translation efficiency of Lea mRNAs in cotton embryos: minor changes during embryogenesis and germination. In earlier studies, only two major patterns of transcript accumulation were seen for 18 late embryogenesis abundant (Lea) gene families in cotton (Gossypium hirsutum L.) during embryogenesis and early germination. Each of these gene families proba...

Dodds, A.W., 2002: Which came first, the lectin/classical pathway or the alternative pathway of complement?. It is a widely accepted canon of immunology that the alternative pathway is more primitive and hence older in evolutionary terms than the lectin/classical pathway. This idea has been reinforced by the discovery of "C3" and "factor B...

Y.H.J.; Takokoro K.; Stadler B.M.; D.W.ck A.L., 1985: Inhibitory effect of histamine on interleukin 2 production. The mechanism of histamine-induced suppression of lectin-stimulated lymphocyte proliferation was studied using interleukin-2 (IL-2) dependent and IL-2 producing T cell lines. Histamine inhibited the proliferation of human peripheral blood lymphocy...

Hata, Y.; Ishida, H.; Ichikawa, E.; Kawato, A.; Suginami, K.; Imayasu, S., 1998: Nucleotide sequence of an alternative glucoamylase-encoding gene (glaB) expressed in solid-state culture of Aspergillus oryzae. The DNA (glaB) and a cDNA-encoding glucoamylase produced in solid-state culture of Aspergillus oryzae were cloned using oligodeoxyribonucleotide probes derived from internal amino acid sequences of the enzyme. Comparison of the nucleotide sequence...

Calabrese, F., 1964: The effects of water treatment on the rooting of vine cuttings. Substantial increases in rooting percentage were achieved by soaking the bases of vine cuttings for 60-96 hours in water at ordinary temperature before planting in February. In a similar but more complex experiment carried out a year later, the hi...

Spesivzeva, V.G.; Kasatkin, J.N.; Semicastnova, A.G.; Egorova, A.I.; Sejdemetov, A.S., 1975: The diagnostical value of pancreas scintigraphy in diabetes mellitus. Radiologia Diagnostica 16(1): 85-90