geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Dissociation between systemic and pulmonary anti-inflammatory effects of dexamethasone in humans


, : Dissociation between systemic and pulmonary anti-inflammatory effects of dexamethasone in humans. British Journal of Clinical Pharmacology 81(5): 865-877

The local pulmonary inflammatory response has a different temporal and qualitative profile compared with the systemic inflammatory response. Although glucocorticoids substantially downregulate the systemic release of acute-phase mediators, it is not clear whether they have comparable inhibitory effects in the human lung compartment. Therefore, we compared the anti-inflammatory effects of a pure glucocorticoid agonist, dexamethasone, on bronchoalveolar lavage and blood cytokine concentrations in response to bronchially instilled endotoxin. In this randomized, double-blind and placebo-controlled trial, 24 volunteers received dexamethasone or placebo and had endotoxin instilled into a lung segment and saline instilled into a contralateral segment, followed by bronchoalveolar lavage. Bronchially instilled endotoxin induced a local and systemic inflammatory response. Dexamethasone strongly blunted the systemic interleukin (IL) 6 and C-reactive protein release. In sharp contrast, dexamethasone left the local release of acute-phase mediators in the lungs virtually unchanged: bronchoalveolar lavage levels of IL-6 were only 18% lower and levels of IL-8 were even higher with dexamethasone compared with placebo, although the differences between treatments were not statistically significant (P = 0.07 and P = 0.08, respectively). However, dexamethasone had inhibitory effects on pulmonary protein extravasation and neutrophil migration. The present study demonstrated a remarkable dissociation between the systemic anti-inflammatory effects of glucocorticoids and its protective effects on capillary leak on the one hand and surprisingly low anti-inflammatory effects in the lungs on the other.

US$19.90

PMID: 26647918

DOI: 10.1111/bcp.12857


Other references

Angell, E.; Biggs, H.; Gahleitner, F.; Dixon-Woods, M., 2010: What do research ethics committees say about applications to conduct research involving children?. To identify issues raised by research ethics committees (RECs) in letters about applications to conduct research involving children. Analysis of 80 provisional and unfavourable opinion decision letters written by RECs in response to applications t...

Xiaodong, Y.; Shujuan, W.; Yaru, X.; Jing, L.; Hongfen, L., 2010: Relational analysis among fibrinogenic Bβ-chain gene polymorphisms and its functional expression and obesity. Recently, there have been a few studies showing the association between obesity and fibrinogen (Fg) gene polymorphisms, but the reasons still do not clear completely. In this research, we studied the relationship among overweight, obesity and -854...

Zava, L.; Boschiero, I., 1950: Some experiences with a new preparation for endovenous anesthesia: farmotal. Acta Anaesthesiologica Belgica 1(6): 505-511

Charles, H.Rringt, N., 1968: Sexual differentiation in socialization and some male genital mutilations. American Anthropologist 70(5): 951-956

Gonzalez Carcacia, J.A.; Lopez Rojas, H., 2005: Morfologia comparativa de ejemplares de Astyanax bimaculatus (Characiformes, Characidae) de las cuencas del Rio Orinoco y del Caribe (Rios Unare, Manzanares y La Toma), Venezuela. Acta Biologica Venezuelica2005): 1-12

Horton, K.M., 2003: CT urogram. Critical Reviews in Computed Tomography 44(4): 177-181

Kostetskaya Y.V.; Petrov L.L.; Petrova Z.I.; Mordvinova V.I., 1969: Distribution and bands of beryllium and fluorine in rocks and minerals of the Dzhida Paleozoic granitoid complex. USSR, Dzhida river region.

Collu, R.; Letarte, J.; Leboeuf, F.; Ducharme, J.R., 1975: Endocrine effects of chronic administration of psychoactive drugs to prepuberal male rats. I: delta9-tetrahydrocannabinol. Life Sciences 16(4): 533-542

Anonymous, 2005: HIT adoption offers big savings, but logistics worries persist. Medicine & Health 59(34): 1, 3-1, 4

Spalletti Luis A., 1987: Granulometric study of sandstone in the Paso del Sapo and Lefipan formations (Cretaceous-Tertiary); Chubut. Boletin Sedimentologico - Catedra de Sedimentologia, Instituto de Geologia, Facultad de Ciencias Naturales, Universidad Nacional de Tucuman 3(1-2): 31-45