geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Downregulated Poly-C binding protein-1 is a novel predictor associated with poor prognosis in Acute Myeloid Leukemia


, : Downregulated Poly-C binding protein-1 is a novel predictor associated with poor prognosis in Acute Myeloid Leukemia. Diagnostic Pathology 10(): 147-147

Depletion of Poly-C binding protein-1(PCBP1) is implicated in various human malignancies. However, the underlying biological effect of PCBP1 in cancers, including acute myeloid leukemia (AML), still remains elusive. The purpose of this study was to examine the expression and clinical outcome of PCBP1in acute myeloid leukemia. Bone marrow fluids of 88 newly diagnosed AML patients were sampled, and the PCBP1 mRNA expression level was evaluated using quantitative RT-PCR. The association between PCBP1 expression and clinicopathological features or the survival status of the patients was assessed by Chi-square test and Kaplan-Meier method. Comparing newly diagnosed AML patients to normal healthy donors, PCBP1 expression was significantly decreased in AML patients (P < 0.001). Conversely, PCBP1 expression had accordingly recovered back to normal in patients with complete remission (P < 0.001). Clinical feature analyses showed that PCBP1 expression was negatively correlated with white blood cell count (P = 0.024). In addition, patients with low PCBP1 expression had poor disease-free survival (11.8% vs. 45.3%; P = 0.01) and overall survival (18.2% vs. 42.4%; P = 0.032), respectively. Taken together, our results showed for the first time that expression of PCBP1 was down-regulated in newly diagnosed AML patients and might be an independent prognostic marker in AML and should to be further investigated.

US$19.90

PMID: 26293996

DOI: 10.1186/s13000-015-0377-y


Other references

Oechslin M., 1979: Rays and ray producers. Mineralienfreund 17(3): 63-65

Ishikawa K.; Saito S., 1975: Effects of various drugs on learning behavior of animals part 4 comparison of gamma amino butyric acid and its derivatives with adrenergic and cholinergic drugs. Japanese Journal of Pharmacology 25(SUPPL): 95P-96P

Nozhkin A.D., 1972: Uranium distribution in the veins of the red jasper-like quartz occurring in skarns and hornfelses. Geologiya i Geofizika 7: 128-130

Sparacio, A.; Capraro, F.; Genna, G.; Prinzivalli, L.; Sparla, S.; Melia, V., 2004: Performance of some clonal selections of Merlot. Berry yield and quality, and must and wine quality were assessed during 1996-98 in 7 clones of grape cv. Merlot growing at Virzi, Monreale, Sicily, in a Guyot trained vineyard established in 1988. All clones showed high berry yields (1.677 to 1.87...

Azizov U.M.; Leont'eva L.I., 1989: Methods for obtaining 2 methyl 1 4 naphthoquinone. Khimiko-Farmatsevticheskii Zhurnal 23(12): 1488-1493

Schellekens, L.A., 1965: A method of suturing an episiotomy. Nederlandsch Tijdschrift Voor Verloskunde en Gynaecologie 65(4): 263-264

Kminiak M., 1971: Seasonal cycle in some amphibian species in the region of spisska magura observed in 1965 1968. Biologia (Bratislava) 26(8): 611-621

Jones, D.T.; Trowbridge, I.S.; Harris, A.L., 2006: Effects of transferrin receptor blockade on cancer cell proliferation and hypoxia-inducible factor function and their differential regulation by ascorbate. Cellular iron is needed for cell survival and hydroxylation of hypoxia-inducible factor-1 alpha (HIF-alpha) by prolyl hydroxylases (PHD). One mechanism of iron uptake is mediated by the cell surface transferrin receptor (TfR). Because iron is requ...

Bergfeld, E.R.sby, R.D.agastin, M.K.nder, J., 1995: 17 beta-estradiol(Compudose) decreases circulating progesterone in pubertal beef heifers. MP 2-A) 5-7

Rausch, M.; Kurt, R.A., 2003: The effects of secondary lymphoid chemokine exposure on T cell receptor signaling molecules and cytoskeletal elements. Journal of the Pennsylvania Academy of Science 76(Abstract and Index Issue): 130, March