+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Dynamic tumor-tracking radiotherapy with real-time monitoring for liver tumors using a gimbal mounted linac

, : Dynamic tumor-tracking radiotherapy with real-time monitoring for liver tumors using a gimbal mounted linac. RadioTherapy and Oncology 117(3): 496-500

Dynamic tumor-tracking stereotactic body radiotherapy (DTT-SBRT) for liver tumors with real-time monitoring was carried out using a gimbal-mounted linear accelerator and the efficacy of the system was determined. In addition, four-dimensional (4D) dose distribution, tumor-tracking accuracy, and tumor-marker positional variations were evaluated. A fiducial marker was implanted near the tumor prior to treatment planning. The prescription dose at the isocenter was 48-60 Gy, delivered in four or eight fractions. The 4D dose distributions were calculated with a Monte Carlo method and compared to the static SBRT plan. The intrafractional errors between the predicted target positions and the actual target positions were calculated. Eleven lesions from ten patients were treated successfully. DTT-SBRT allowed an average 16% reduction in the mean liver dose compared to static SBRT, without altering the target dose. The average 95th percentiles of the intrafractional prediction errors were 1.1, 2.3, and 1.7 mm in the left-right, cranio-caudal, and anterior-posterior directions, respectively. After a median follow-up of 11 months, the local control rate was 90%. Our early experience demonstrated the dose reductions in normal tissues and high accuracy in tumor tracking, with good local control using DTT-SBRT with real-time monitoring in the treatment of liver tumors.


PMID: 26362722

DOI: 10.1016/j.radonc.2015.08.033

Other references

Yahata, H.; Shinozaki, K.; Tanji, H.; Uchida, K.; Oshiro, H.; Takahashi, M.; Dohi, K., 1997: Evaluation of extended lymph nodes dissection for gastric cancer patients according to the depth of cancer penetration. Gastroenterology 112(4 SUPPL ): A684

Steward,; Elmarakby, S.A.; Maslanka, R.; Kumar, S.; Sikka, H.C., 1994: Metabolic fate and disposition of 2-acetylaminofluorene in rainbow trout, Oncorhynchus mykiss. Rainbow trout, Shasta strain, in contrast to several mammalian species, are highly resistant to hepatocarcinogenesis by 2-acetylaminofluorene (AAF). In order to examine factors that may contribute to this resistance, we investigated the metabolic...

Carranza, S.; Littlewood, D.T.mothy J.; Clough, K.A.; Ruiz Trillo, I.; Baguna, J.; Riutort, M., 1998: A robust molecular phylogeny of the Tricladida with a discussion on morphological synapomorphies. The suborder Tricladida (Platyhelminthes: Turbellaria, Seriata) comprises most well-known species of free-living flatworms. Four infraorders are recognized: (i) the Maricola (marine planarians); (ii) the Cavernicola (a group of primarily cavernico...

Fauconnier, Jérôme., 2009: PPS killed me. Presse Medicale 38(11): 1560-1561

Witten, J.; Ruschak, A.; Poterba, T.; Jaramillo, A.; Miranker, A.D.; Jaswal, S.S., 2016: Mapping Protein Conformational Landscapes under Strongly Native Conditions with Hydrogen Exchange Mass Spectrometry. The thermodynamic stability and kinetic barriers separating protein conformations under native conditions are critical for proper protein function and for understanding dysfunction in diseases of protein conformation. Traditional methods to probe...

Luz'yanina G.A., 1984: Diabetes mellitus with severe vascular involvement in a 13 year old child. Voprosy Okhrany Materinstva i Detstva 29(8): 72-73

Phipps, P.M.; Elliott, A.P., 1985: Evaluation of nematicides for control of plant parasitic nematodes on two cultivars of corn, 1984. Maize cultivars SS775 and SS910 showed no significant yield response to the application of 8 nematicides in fields infested with Macroposthonia and Tylenchorhynchus spp. in Virginia, USA.

Lenahan, R.; Thomas, J.; Taylor, D.; Call, D.; Padberg, D., 1972: Consumer reaction to nutrition information on food product labels. Search 2 (15)

Hosseinzadeh, G.; Maghari, A.; Saboury, A.A.; Moosavi-Movahedi, A.A., 2016: Unfolding of insulin at the surface of ZnO quantum dots. ZnO quantum dots (QDs) have been used in many biomedical applications such as bioimaging, cancer treatments and etc. Crystallinity, particle size, optical absorption and photoluminescence spectra of ZnO QDs were analyzed by X-ray diffraction (XRD)...

Volosivets, A.I., 1964: The frequency with which phage-resistant mutants are formed in cell populations of virulent strains of Pasteurella pestis. Byul Eksp Biol Med 57(3): 71-75