+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Dysfunction of cortical dendritic integration in neuropathic pain reversed by serotoninergic neuromodulation

, : Dysfunction of cortical dendritic integration in neuropathic pain reversed by serotoninergic neuromodulation. Neuron 86(1): 233-246

Neuropathic pain is caused by long-term modifications of neuronal function in the peripheral nervous system, the spinal cord, and supraspinal areas. Although functional changes in the forebrain are thought to contribute to the development of persistent pain, their significance and precise subcellular nature remain unexplored. Using somatic and dendritic whole-cell patch-clamp recordings from neurons in the anterior cingulate cortex, we discovered that sciatic nerve injury caused an activity-dependent dysfunction of hyperpolarization-activated cyclic nucleotide-regulated (HCN) channels in the dendrites of layer 5 pyramidal neurons resulting in enhanced integration of excitatory postsynaptic inputs and increased neuronal firing. Specific activation of the serotonin receptor type 7 (5-HT7R) alleviated the lesion-induced pathology by increasing HCN channel function, restoring normal dendritic integration, and reducing mechanical pain hypersensitivity in nerve-injured animals in vivo. Thus, serotoninergic neuromodulation at the forebrain level can reverse the dendritic dysfunction induced by neuropathic pain and may represent a potential therapeutical target.


PMID: 25819610

DOI: 10.1016/j.neuron.2015.03.003

Other references

Burgis, D.S., 1951: Nut grass control with 2,4-D. The data presented show that the stand of nut grass in infested fields can be greatly reduced by three sprayings with 2, 4-D (sodium 2, 4-dichlorophenoxyacetic acid) at the rate of 5 1b. actual per acre. Repeated sprayings at yearly intervals shou...

Fowler, M.R.; Atanassova, A.I.; Scott, N.W.; Slater, A.; Elliott, M.C., 1999: Characterisation of the cell division cycle related gene Bvcrk1 Gene structure and expression in Beta vulgaris. Biochemical Society Transactions 27(3): A96

Ugarte, G.; Iturriaga, H.; Valenzuela, J.; Inzunza, I., 1964: The effect of tridihexethyl-clymephenoxalone on gastric secretion induced by the maximal histamine test. Volume of basal secretion was decreased by 63% while HCl concentration was reduced by 69% after administration of this agent. Post-histamine secretion was reduced in volumen by 35% and acidity by 44% when using similar doses of the inhibitor. Indi...

Linden, R.J.; Sreeharan, N., 1979: Does the renal humoral response to stimulation of atrial receptors include a natriuresis? [proceedings. Journal of Physiology 291: 43p-44p

Anonymous, 1998: Small animal internal medicine. Features new to the second edition are a 10-chapter section on infectious diseases, a chapter on systemic arterial hypertension, algorithms to assist decision-making, and colour coding of the many summary tables (to distinguish aetiology, differen...

Escobar G.J.; Bradley R.L.Jr, 1990: Effect of mechanical treatment on the free fatty acid content of raw milk. The relative effect of different milking procedures, physical handling, and pumping on lipolytic activity in milk was investigated. Six cows were selected by their stage of lactation from the University of Wisconsin dairy herd. Samples of raw milk...

Manrique P.E.; Revilla D.R., 1982: Characterization of a system of sheep production on irrigated land. Sheep farming systems employed on 3 family farms in a recently irrigated area of Zaragoza where sheep had not previously been kept were analysed. Flock sizes ranged from 227 to 318 and in the absence of other livestock the forage supply was based...

A.B.uni; A.R.C.ntessa, 1961: In-hibition of oxidative phosphorylation by an antipyretic drug. Biochemical Pharmacology 6(4): 0-277

Rauh, M.J.; Blackmore, V.; Andrechek, E.R.; Tortorice, C.G.; Daly, R.; Lai, V.K.; Pawson, T.; Cardiff, R.D.; Siegel, P.M.; Muller, W.J., 1999: Accelerated mammary tumor development in mutant polyomavirus middle T transgenic mice expressing elevated levels of either the Shc or Grb2 adapter protein. The Grb2 and Shc adapter proteins play critical roles in coupling activated growth factor receptors to several cellular signaling pathways. To assess the role of these molecules in mammary epithelial development and tumorigenesis, we have generate...

Shorey, J.; Mushahwar, I.K.; Shorey, J.; Overby, L.R., 1982: Reexamination of hepatitis B virus subtypes and e-antigen expression by radioimmunoassays. Radioimmunoassay methods were used to determine both the hepatitis B virus (HBV) subtype and hepatitis B e antigen (HBeAg) and antibody (anti-HBe) status of a group of hepatitis B surface antigen (HBsAg)-positive blood donors. The study involved s...