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Echogenic Glycol Chitosan Nanoparticles for Ultrasound-Triggered Cancer Theranostics

, : Echogenic Glycol Chitosan Nanoparticles for Ultrasound-Triggered Cancer Theranostics. Theranostics 5(12): 1402-1418

Theranostic nanoparticles hold great promise for simultaneous diagnosis of diseases, targeted drug delivery with minimal toxicity, and monitoring of therapeutic efficacy. However, one of the current challenges in developing theranostic nanoparticles is enhancing the tumor-specific targeting of both imaging probes and anticancer agents. Herein, we report the development of tumor-homing echogenic glycol chitosan-based nanoparticles (Echo-CNPs) that concurrently execute cancer-targeted ultrasound (US) imaging and US-triggered drug delivery. To construct this novel Echo-CNPs, an anticancer drug and bioinert perfluoropentane (PFP), a US gas precursor, were simultaneously encapsulated into glycol chitosan nanoparticles using the oil in water (O/W) emulsion method. The resulting Echo-CNPs had a nano-sized particle structure, composing of hydrophobic anticancer drug/PFP inner cores and a hydrophilic glycol chitosan polymer outer shell. The Echo-CNPs had a favorable hydrodynamic size of 432 nm, which is entirely different from the micro-sized core-empty conventional microbubbles (1-10 μm). Furthermore, Echo-CNPs showed the prolonged echogenicity via the sustained microbubble formation process of liquid-phase PFP at the body temperature and they also presented a US-triggered drug release profile through the external US irradiation. Interestingly, Echo-CNPs exhibited significantly increased tumor-homing ability with lower non-specific uptake by other tissues in tumor-bearing mice through the nanoparticle's enhanced permeation and retention (EPR) effect. Conclusively, theranostic Echo-CNPs are highly useful for simultaneous cancer-targeting US imaging and US-triggered delivery in cancer theranostics.


PMID: 26681985

DOI: 10.7150/thno.13099

Other references

Dorenbos, G.; Morohoshi, K., 2013: Pore morphologies and diffusion within hydrated polyelectrolyte membranes: homogeneous vs heterogeneous and random side chain attachment. Using dissipative particle dynamics pore morphologies within model ionomer membranes are simulated. The ionomers are composed of hydrophobic backbones and side chains that are end-linked with a hydrophilic acid containing site. The separation dist...

Messias Reason, I.Jose.; Schafranski, M.Derbi.; Jensenius, J.Christian.; Steffensen, R., 2006: The association between mannose-binding lectin gene polymorphism and rheumatic heart disease. Mannan-binding lectin (MBL) is an innate pattern recognition molecule known to play a key role in pathogen clearance. As MBL2 gene polymorphism is associated to an increased susceptibility to infection, we aimed to determine genetic variations in...

Ferrer, M.; Méndez-García, C.; Rojo, D.; Barbas, C.; Moya, Aés., 2016: Antibiotic use and microbiome function. NlmCategory="UNASSIGNED">Our microbiome should be understood as one of the most complex components of the human body. The use of β-lactam antibiotics is one of the microbiome covariates that influence its composition. The extent to w...

Harmening, D.M.; Lemery, L.D., 1997: Introduction to hemostasis An overview of hemostatic mechanism, platelet structure and function, and extrinsic and intrinsic systems. Harmening, D M Clinical hematology and fundamentals of hemostasis, Third edition : 481-508

Komvilaisak, P.; Grant, R.; Weitzman, S.; Brandao, L.; Blaser, S.; Chait, P.; Connolly, B.; Williams, S., 2007: Epidural hematoma following tissue plasminogen activator (tPA) therapy for pulmonary embolism in a pediatric patient with stage IV Burkitt's lymphoma: a case report. N,N-dimethylformamide (DMF) could be readily absorbed via skin and inhalation routes. It is difficult, however, to separate the internal dose contribution from skin vapor and inhalation exposure. This study attempts to quantitatively determine the...

Demetrescu, M.; Demetrescu, M., 1962: Facilitatory and inhibitory action of the chemical stimulation of the reticular formation upon the thalamo-cortical evoked potential. Revue des Sciences Medicales 7: 37-40

Mueller, C.; Held, W.; Imboden, M.A.; Carnaud, C., 1995: Accelerated beta-cell destruction in adoptively transferred autoimmune diabetes correlates with an increased expression of the genes coding for TNF-alpha and granzyme A in the intra-islet infiltrates. Autoimmune destruction of beta-cells in nonobese diabetic (NOD) mice is greatly accelerated by adoptive cotransfer of syngeneic CD4+ and CD8+ T-cells from diabetic animals into newborn NOD mice. We followed, by in situ hybridization, the appearanc...

Capurro, M.; Almeida, G.; Hozbor, F.; Monterubbianesi, M., 2006: Scrotal circumference and sperm production in Ost Frisian rams during opposite photoperiods. Revista Argentina de Produccion Animal 26(Supl. 1): rf 19

Rothschild, W., 1908: A new Papilio from Africa. Entom Mag London, 44 249

Van Den Anker, J.; Rajagopalan, P.; Rakhmanina, N.; Murty, V.; Sundaresan, P., 2002: Single dose pharmacokinetics of faropenem daloxate in adolescent subjects. Clinical Pharmacology & Therapeutics 71(2): P93, February