geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effect of the Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 2 AZD8529 on Incubation of Methamphetamine Craving After Prolonged Voluntary Abstinence in a Rat Model


, : Effect of the Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 2 AZD8529 on Incubation of Methamphetamine Craving After Prolonged Voluntary Abstinence in a Rat Model. Biological Psychiatry 78(7): 463-473

Cue-induced methamphetamine craving increases after prolonged forced (experimenter-imposed) abstinence from the drug (incubation of methamphetamine craving). Here, we determined whether this incubation phenomenon would occur under conditions that promote voluntary (self-imposed) abstinence. We also determined the effect of the novel metabotropic glutamate receptor 2 positive allosteric modulator, AZD8529, on incubation of methamphetamine craving after forced or voluntary abstinence. We trained rats to self-administer palatable food (6 sessions) and then to self-administer methamphetamine under two conditions: 12 sessions (9 hours/day) or 50 sessions (3 hours/day). We then assessed cue-induced methamphetamine seeking in extinction tests after 1 or 21 abstinence days. Between tests, the rats underwent either forced abstinence (no access to the food- or drug-paired levers) or voluntary abstinence (achieved via a discrete choice procedure between methamphetamine and palatable food; 20 trials per day) for 19 days. We also determined the effect of subcutaneous injections of AZD8529 (20 and 40 mg/kg) on cue-induced methamphetamine seeking 1 day or 21 days after forced or voluntary abstinence. Under both training and abstinence conditions, cue-induced methamphetamine seeking in the extinction tests was higher after 21 abstinence days than after 1 day (incubation of methamphetamine craving). AZD8529 decreased cue-induced methamphetamine seeking on day 21 but not day 1 of forced or voluntary abstinence. We introduce a novel animal model to study incubation of drug craving and cue-induced drug seeking after prolonged voluntary abstinence, mimicking the human condition of relapse after successful contingency management treatment. Our data suggest that positive allosteric modulators of metabotropic glutamate receptor 2 should be considered for relapse prevention.

US$19.90

PMID: 25861699

DOI: 10.1016/j.biopsych.2015.02.018


Other references

Bloem, T.J.; Razzoog, M.E., 1982: An index for assessment of oral health in the edentulous population. Special Care in Dentistry 2(3): 121-124

Plasschaert, F.; Vandekerckhove, B.; Verdonk, R., 1998: A known technique for meniscal repair in common practice. In this retrospective study, we calculated the healing rate of meniscal repairs performed with an outside-in technique. We describe complications encountered and evaluate some known criteria used in the decision to perform a meniscal repair instea...

Jenkins R.; Koh C.; Meek K.; Lipsky P., 1991: Determination of t cell receptor variable region gene usage with the polymerase chain reaction pcr. FASEB Journal 5(4): A613

Viryasov S.N., 1986: Evaluation of the amplitude of changes in the distance between membranes in contact under the effect of external voltage. A quantitative evaluation of the amplitude of changes in the distance between two membranes due to changes in transmembrane voltage has been theoretically performed. The results are in good agreement with the data of bilayer lipid membrane experim...

Smith D.G., 1975: Wenlock plant spores and tetrads from County Mayo, Ireland. Geological Magazine 112(4): 411-414

Kwiatkowski, Z.A.; Kunicki-Goldfinger, J.H., 1995: Obituary notice. Wladyslaw J.H. Kunicki-Goldfinger 1916-1995. Microbiologist and philosopher. Medycyna Doswiadczalna i Mikrobiologia 47(3-4): 113-115

Wiesner, I.; Wiesnerova, D., 2004: Statistical Correlations of Primer Thermodynamic Stability DG(degree) for Enhanced Flax ISSR-PCR Cultivar Authentication. Journal of Agricultural and Food Chemistry 52(9): 68-71

Ciriaco, F.M.; Henry, D.D.; Mercadante, V.R.G.; Schulmeister, T.; Ruiz-Moreno, M.; Lamb, G.C.; DiLorenzo, N., 2016: Effects of different levels of supplementation of a 50:50 mixture of molasses:crude glycerol on performance, Bermuda grass hay intake, and nutrient digestibility of beef cattle. Two experiments were performed to evaluate the effects of different levels of supplementation with a 50:50 (as-fed) mixture of molasses:crude glycerol on animal performance, total tract digestibility of nutrients, and ruminal in situ degradability...

Frommel, E., 1963: Pharmacodynamics of drugs used to control motion sickness. Experimental methods and new synthesis in the phenothiazine group: (Beta-dimethylaminoethyl)-aminoacetyl-10-phenothiazine or 462. Arzneimittel-Forschung 13: 573-581

Nunn, S., 2008: Enterprise content management from the ground up. Journal of Ahima 79(2): 46-47