geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of moderate intensity static magnetic fields on human bone marrow-derived mesenchymal stem cells


, : Effects of moderate intensity static magnetic fields on human bone marrow-derived mesenchymal stem cells. Bioelectromagnetics 36(4): 267-276

This study aimed to explore effects of static magnetic fields (SMFs) of moderate intensity (3-50 mT) as biophysical stimulators of proliferation and osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells (MSCs). MSCs were exposed to SMFs of three intensities: 3, 15, and 50 mT. Proliferation was assessed by cell counting and bromodeoxyuridine incorporation, and differentiation by measuring alkaline phosphatase (ALP) activity, calcium content, mineralized nodule formation, and transcripts of osteogenic markers. Moderate intensity SMFs increased cell proliferation, ALP activity, calcium release, and mineralized nodule formation in a dose- and time-dependent manner, which peaked at 15 mT. In the same manner, they upregulated expression of osteogenic marker genes such as ALP, bone sialoprotein 2 (BSP2), collagen1a1 (COL1a1), osteocalcin (OCN), osteonectin (ON), osteopontin (OPN), osterix (OSX), and runt-related transcription factor 2 (RUNX2) with peak at 15 mT after 14 or 21 days of exposure. Results demonstrate that moderate intensity SMFs promote proliferation and osteoblastic differentiation of MSCs. This effect could help to improve MSC responses during osseointegration between a dental implant and surrounding bone.

US$19.90

PMID: 25808160

DOI: 10.1002/bem.21903


Other references

Marchbanks, R.M., 1967: Inhibitory effects of lysergic acid derivatives and reserpine on 5-HT binding to nerve ending particles. In order to assess the functional significance of a high-affinity binding of 5-HT [5-hydroxytryptamine] to nerve ending particles the effects of lysergic acid derivatives and other pharmacological antagonists of 5-HT on the binding were investigat...

Dyster, L.M.; Papisero, L.D.; Poiesz, B.J., 1994: Performance evaluation of microtiter-based DNA hybridization assay formats for the specific detection of HIV-1 gene sequences. Clinical Chemistry 40(4): 657

Bracht, Lívia.; Barbosa, C.Patrícia.; Caparroz-Assef, S.Martins.; Cuman, R.Kenji.Nakamura.; Ishii-Iwamoto, E.Luiza.; Bracht, A.; Bersani-Amado, C.Aparecida., 2013: Effects of simvastatin, atorvastatin, ezetimibe, and ezetimibe + simvastatin combination on the inflammatory process and on the liver metabolic changes of arthritic rats. In this study, simvastatin, atorvastatin, ezetimibe, and ezetimibe + simvastatin combination were administered to arthritic rats, first to determine their effects on the inflammatory response, employing a low-dose adjuvant-induced arthritis model...

Curt, G.A., 2001: Terrorism and cancer. Oncologist 6(5): 401-401

Cabré, A.; Lázaro, I.; Girona, J.; Manzanares, J.Maria.; Marimón, F.; Plana, Núria.; Heras, M.; Masana, Lís., 2008: Plasma fatty acid binding protein 4 is associated with atherogenic dyslipidemia in diabetes. The aim of this study was to evaluate the impact of adipocyte fatty acid binding protein 4 (FABP4) on the lipid profile in type 2 diabetic subjects. Plasma levels of FABP4 and adiponectin and an extensive lipid profile were analyzed in 169 type 2...

Sass Hans H., 1990: Construction of a new quay wall with accompanying measurement program. Bautechnik (Berlin, 1984) 67(12): 403-410

Buzhinskaya, GN., 2002: The life and work of P.V. Ushakov (1903-1992).. Trudy Zoologicheskogo Instituta, 292: 77-97

Field, M., 1979: Causal inferences in behavioral research. Ans. Advances in Nursing Science 2(1): 81-93

Graves, J.A.M., 1987: The evolution of mammalian sex chromosomes and dosage compensation: clues from marsupials and monotremes. A review. The X- and Y-chromosomes of eutherian mammals may have evolved from a homomorphic pair in a common ancestor, by a gradual size reduction of the Y, accompanied by a spreading of inactivation into newly unpaired regions of the X.

Anonymous, 1963: The Malayan Agricultural Journal. The Malayan Agricultural Journal is now published (as from Nov., 1963) by the Ministry of Agriculture and Co-operatives under the title Malaysian Agricultural Journal. In addition to its previous function it is planned to serve Sabah and Sarawak.