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Elevated levels of circulating immune complexes -C3d and-C1q as a criterion for acute extraintestinal manifestations of ulcerative colitis


, : Elevated levels of circulating immune complexes -C3d and-C1q as a criterion for acute extraintestinal manifestations of ulcerative colitis. Eksperimental'naia i Klinicheskaia Gastroenterologiia 7): 18-24

During ulcerative colitis in the exacerbation phase the high level of circulating immune complexes -C1q and -C3d (CIC-C1q and -C3d) was detected in 35.4% and 28.9% of patients respectively. This raise of CIC-C1q and -C3d level was accompanied by increase of clinical and endoscopic activity of ulcerative colitis (AC). In 45.4% of AC patients with extraintestinal onsets CIC-C3d was detected and only in 11.7% of patients CIC-C1q was found. These data confirm that activation of the humoral immunity accompanied by increase in formation of immune complexes is characteristic for AC patients with extraintestinal onsets. CIC emergence in serum of AC patients is considered as a prognostically unfavorable sign indicating that the disease may be accompanied by extraintestinal onsets.

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PMID: 25842401


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