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Emerging Immunotargets in Bladder Cancer

, : Emerging Immunotargets in Bladder Cancer. Current Drug Targets 17(7): 757-770

Bladder cancer treatment, namely systemic therapy, was dominated in the last three decades due to the absence of newer therapeutic options other than chemotherapy regimens. Chemotherapy, by itself, both in first and second-line seems to have achieved the modest plateau of its possibilities at the cost of non-negligible toxicity. Targeted therapies, which changed the therapy of many different tumors, seem rather ineffective in bladder cancer. More recently, a new generation of Immunotherapy based regimens represent the most promising avenue for the future systemic treatment of bladder cancer. Checkpoint inhibition, namely PD1/PD-L1 pathway inhibition, showed impressive results in many other tumor types and are expected to become a major player in the treatment of bladder cancer. Other immunotherapy strategies such as fusion proteins represent distant, although promising, options. A brief overview of the current status of bladder cancer immunotherapy is presented.


PMID: 26844572

Other references

LaPointe, G.; Viau, S.; LeBlanc, D.; Robert, N.; Morin, A., 1994: Cloning, sequencing, and expression in Escherichia coli of the D-hydantoinase gene from Pseudomonas putida and distribution of homologous genes in other microorganisms. Pseudomonas putida DSM 84 produces N-carbamyl-D-amino acids from the corresponding D-5-monosubstituted hydantoins. The gene encoding this D-hydantoinase enzyme was cloned and expressed in Escherichia coli. The nucleotide sequence of the 1.8-kb ins...

Choi, H-Neul.; Kang, M-Jung.; Lee, S-Jin.; Kim, J-In., 2014: Ameliorative effect of myricetin on insulin resistance in mice fed a high-fat, high-sucrose diet. Obesity-associated insulin resistance is a strong risk factor for type 2 diabetes mellitus. The aim of this study was to investigate the effect of myricetin on adiposity, insulin resistance, and inflammatory markers in mice with diet-induced insul...

Kakinuma, Y.; Yasumura, K.; Igarashi, K., 1999: Potassium/proton antiport system is dispensable for growth of Enterococcus hirae at low pH. An energy-dependent K+/H+ antiport system is found in Enterococcus hirae ATCC 9790 cultured in a standard complex medium (Y. Kakinuma, and K. Igarashi, J. Biol. Chem. 263:14166-14170, 1988). We have now found that the activity of this antiport sys...

Loidl-Stahlhofen, A.; Hannemann, K.; Felde, R.; Spiteller, G., 1995: Epoxidation of plasmalogens: source for long-chain alpha-hydroxyaldehydes in subcellular fractions of bovine liver. 1. Masked long-chain alpha-hydroxyaldehydes were trapped in all subcellular fractions of bovine liver by application of pentafluorbenzyloxime derivatization [van Kuijk, Thomas, Stephens and Dratz (1986) Biochem. Biophys. Res. Commun. 139, 144-149]...

Mole, R.H., 1965: Dose response relationships, particularly in mammalian radiobiology. Annual Review of Nuclear Science 15: 207-240

Mills, I.H.; Newport, P.A.; Obika, L.F., 1983: The role of the kallikrein/kinin system in the excretion of water in dogs. Advances in Experimental Medicine and Biology 156: 907-918

Boissier J R.; Giudicelli J F.; Viars P.; Larno S., 1968: Interaction at the tracheo bronchial tree between beta adrenolytics and some volatile general anesthesics. Presse Medicale 76(26): 1288

Sarman, I., 2001: I'm circumcised, but not sexually mutilated!. Lakartidningen 98(13): 1570-1571

Marks, G.A.; Birabil, C.G., 1998: Enhancement of rapid eye movement sleep in the rat by cholinergic and adenosinergic agonists infused into the pontine reticular formation. The cholinergic agonist carbachol (1.1 mM) and the adenosinergic agonist cyclohexyladenosine (0.1 mM) were microinjected (60 nl) into the region of the caudal, oral pontine reticular formation of the rat. Local intracerebral infusion of each recep...

Goyret, Jín.; Farina, W.M., 2005: Non-random nectar unloading interactions between foragers and their receivers in the honeybee hive. Nectar acquisition in the honeybee Apis mellifera is a partitioned task in which foragers gather nectar and bring it to the hive, where nest mates unload via trophallaxis (i.e. mouth-to-mouth transfer) the collected food for further storage. Becau...