geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls B-cell immunity through degradation of the death receptor CD95/Fas


, : Endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls B-cell immunity through degradation of the death receptor CD95/Fas. Proceedings of the National Academy of Sciences of the United States of America 113(37): 10394-9

Humoral immunity involves multiple checkpoints during B-cell development, maturation, and activation. The cell death receptor CD95/Fas-mediated apoptosis plays a critical role in eliminating the unwanted activation of B cells by self-reactive antigens and in maintaining B-cell homeostasis through activation-induced B-cell death (AICD). The molecular mechanisms controlling AICD remain largely undefined. Herein, we show that the E3 ubiquitin ligase Hrd1 protected B cells from activation-induced cell death by degrading the death receptor Fas. Hrd1-null B cells exhibited high Fas expression during activation and rapidly underwent Fas-mediated apoptosis, which could be largely inhibited by FasL neutralization. Fas mutation in Hrd1 KO mice abrogated the increase in B-cell AICD. We identified Hrd1 as the first E3 ubiquitin ligase of the death receptor Fas and Hrd1-mediated Fas destruction as a molecular mechanism in regulating B-cell immunity.

US$19.90

PMID: 27573825

DOI: 10.1073/pnas.1606742113


Other references

Liu, C.; Toma, I.Cristian.; Mastrogiacomo, M.; Krettek, C.; von Lewinski, G.; Jagodzinski, M., 2013: Meniscus reconstruction: today's achievements and premises for the future. Injuries of the meniscus remain a burden for the development of premature cartilage degeneration and osteoarthritis. This review surveys all treatment options and focuses on the recent development of tissue engineering. Tissue engineering of the m...

Martinez, S., 2002: Miocene and modern malacological Provinces from southwestern Atlantic Las provincias malacologicas miocenas y recientes del Atlantico sudoccidental. Southwestern Atlantic Recent and Miocene Malacological Provinces are recognized as properly delimited, according to Jaccard and Simpson association coefficients. The Recent Argentinean Province is considered a Provincetone between the Magellanic a...

Krah, R.; Kozyavkin, S., A.; Slesarev, A., I.; Gellert, M., 1996: A two-subunit type I DNA topoisomerase (reverse gyrase) from an extreme hyperthermophile. A recently described reverse gyrase from the hyperthermophilic methanogen Methanopyrus kandleri is the only known example of a heterodimeric type I topoisomerase. The enzyme is made up of a 42-kDa subunit which covalently interacts with DNA (RgyA)...

Sedighi, B.; Shafiei, K.; Azizpour, I., 2016: Topiramate-induced paresthesia is more frequently reported by migraine than epileptic patients. Topiramate is an approved and effective drug in migraine prophylaxis. Paresthesia is the most commonly reported side effect. The primary objective of this study was to compare the frequency of topiramate-induced paresthesia in migraine headache to...

Kondratenko, P.T.; Skliarevskii, L.I.; Khotin, A.A., 1963: Problems In Biological Science On The Study And Use Of Medicinal Plants. Aptechnoe Delo 12: 3-8

Hazon, J., 1979: Complications of transfusion. Soins; la Revue de Reference Infirmiere 24(12): 33-35

Li, Z.; Bryant, A.E.; Parimon, T.; Stevens, D.L., 2012: Cardiac dysfunction in StrepTSS: group A streptococcus disrupts the directional cardiomyocyte-to-macrophage crosstalk that maintains macrophage quiescence. Myocardial dysfunction in group A streptococcal (GAS) toxic shock syndrome (StrepTSS) is characterized by severe biventricular dilatation and a striking reduction in ventricular performance; however, the mechanisms have not been fully elucidated....

Roberts, C.K.; Barnard, R.James., 2004: Effects of exercise and diet on chronic disease. Currently, modern chronic diseases, including cardiovascular diseases, Type 2 diabetes, metabolic syndrome, and cancer, are the leading killers in Westernized society and are increasing rampantly in developing nations. In fact, obesity, diabetes,...

Karhunen, J.; Raivio, P.; Maasilta, P.; Sihvo, E.; Suojaranta-Ylinen, R.; Vento, A.; Salminen, U.S., 2010: Impact of early angiographic evaluation on the frequency of emergency reoperations after coronary bypass surgery. early graft failure following coronary bypass surgery results in elevated morbidity and mortality. This study focused on the impact of angiographic graft evaluation. of 5251 coronary artery bypass grafting (CABG) patients, 36 with postoperative pe...

Manoukas, AG., 1985: Diets improving pupal yield of the olive fruit fly at high larval densities. Three experimental diets were formulated for rearing the tephritid Dacus oleae, and their effects on larval survival, larval growth, pupal yield and adult emergence were studied. The diets were obtained by increasing the ingredients of a basic con...