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Enhancing the copper(II) complexes cytotoxicity to cancer cells through bound to human serum albumin

, : Enhancing the copper(II) complexes cytotoxicity to cancer cells through bound to human serum albumin. Journal of Inorganic Biochemistry 144: 47-55

We use Schiff-base salicylaldehyde benzoylhydrazone (HL) as the ligand for copper(II), resulting in the complexes [CuCl(L)]·H2O (C1), [CuNO3(L)]·H2O (C2) and [CuBr(L)]2 (C3). We characterize the Cu(II) compounds' interactions with human serum albumin (HSA) using fluorescence spectroscopy and molecular docking. These studies revealed that Cu(II) compounds propensity bound to IIA subdomain of HSA possible by hydrophobic interactions and hydrogen bond. Cu(II) compounds produce intracellular reactive oxygen species (ROS) in cancer cells. Complexes of HSA and copper(II) compounds enhance about 2-fold cytotoxicity in cancer cells but do not raise cytotoxicity levels in normal cells in vitro. Compared with C3 alone, HSA-C3 complex promotes HepG2 cell apoptosis and has a stronger capacity to promote cell cycle arrest at the G2/M phase of HepG2.


PMID: 25573806

DOI: 10.1016/j.jinorgbio.2014.12.012

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Antopol, W.; Glick, D., 1938: Organs as a source of factors capable of eliciting the Shwartz-man phenomenon. Fractions prepared from pancreas, testis, liver, kidney, brain, placenta, muscle, breast and uterus possess provocative Shwartzman phenomenon factors (although results were irregular in some cases); similar fractions from spleen do not. Only the f...

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Purdon, Carey., 2001: Results of the Lake Dore odonate count. Ontario Insects. September; 71: 20-21

Bain, O.P.tit, G.P.ulain, B., 1978: Validity of the two species, Onchocerca lienalis and Onchocerca gutturosa from cattle. Annales de parasitologie humaine et comparee 53(4): 421-430

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Lal H.; Karkalas Y.; Smith N.; Singh M., 1971: Behavioral analysis of the effects of tri fluoro perazine and chloral hydrate in patients under treatment with psycho pharmacologic agents. Toxicology & Applied Pharmacology 19(2): 420

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Hevesy, G.V.; Hofer, E., 1934: Water exchange in fishes. In experiments with H22O it is shown that a rapid exchange occurs between the body of fish and the surrounding fluid. Equilibrium is established after a few hours. The question of the substitution of H22 in carbon compounds in the body is consider...

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