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Enhancing the copper(II) complexes cytotoxicity to cancer cells through bound to human serum albumin


, : Enhancing the copper(II) complexes cytotoxicity to cancer cells through bound to human serum albumin. Journal of Inorganic Biochemistry 144: 47-55

We use Schiff-base salicylaldehyde benzoylhydrazone (HL) as the ligand for copper(II), resulting in the complexes [CuCl(L)]·H2O (C1), [CuNO3(L)]·H2O (C2) and [CuBr(L)]2 (C3). We characterize the Cu(II) compounds' interactions with human serum albumin (HSA) using fluorescence spectroscopy and molecular docking. These studies revealed that Cu(II) compounds propensity bound to IIA subdomain of HSA possible by hydrophobic interactions and hydrogen bond. Cu(II) compounds produce intracellular reactive oxygen species (ROS) in cancer cells. Complexes of HSA and copper(II) compounds enhance about 2-fold cytotoxicity in cancer cells but do not raise cytotoxicity levels in normal cells in vitro. Compared with C3 alone, HSA-C3 complex promotes HepG2 cell apoptosis and has a stronger capacity to promote cell cycle arrest at the G2/M phase of HepG2.

US$19.90

PMID: 25573806

DOI: 10.1016/j.jinorgbio.2014.12.012


Other references

Antopol, W.; Glick, D., 1938: Organs as a source of factors capable of eliciting the Shwartz-man phenomenon. Fractions prepared from pancreas, testis, liver, kidney, brain, placenta, muscle, breast and uterus possess provocative Shwartzman phenomenon factors (although results were irregular in some cases); similar fractions from spleen do not. Only the f...

Cordes, F.C.; Barkan, H., 1960: Hans BARKAN. Transactions of the American Ophthalmological Society 58: 7-8

Purdon, Carey., 2001: Results of the Lake Dore odonate count. Ontario Insects. September; 71: 20-21

Bain, O.P.tit, G.P.ulain, B., 1978: Validity of the two species, Onchocerca lienalis and Onchocerca gutturosa from cattle. Annales de parasitologie humaine et comparee 53(4): 421-430

Esclapez, M.; Tillakaratne, N.J.; Kaufman, D.L.; Tobin, A.J.; Houser, C.R., 1994: Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms. Two isoforms of glutamic acid decarboxylase (GAD67 and GAD65) and their mRNAs were localized in the rat brain by immunohistochemistry and nonradioactive in situ hybridization methods with digoxigenin-labeled cRNA probes. In most brain regions, bot...

Lal H.; Karkalas Y.; Smith N.; Singh M., 1971: Behavioral analysis of the effects of tri fluoro perazine and chloral hydrate in patients under treatment with psycho pharmacologic agents. Toxicology & Applied Pharmacology 19(2): 420

Dirks, B.M., 1954: The properties of some fungal liupases and their role in grain deterioration. Investigations at the University of Minnesota of the lipase activity of wheat germ and the moulds Aspergillus candidus and a Penicillium sp. indicated that the appearance of fat acidity in stored grain was apparently due chiefly to the activity of...

Viswanatha, B., 2009: Nonseptic lateral sinus thrombosis: the role of the otolaryngologist. Nonseptic lateral sinus thrombosis differs from septic lateral sinus thrombosis in that it is not associated with ear or sinus infection. Mastoid changes are frequently detected on computed tomography or magnetic resonance imaging in cases of nons...

Hevesy, G.V.; Hofer, E., 1934: Water exchange in fishes. In experiments with H22O it is shown that a rapid exchange occurs between the body of fish and the surrounding fluid. Equilibrium is established after a few hours. The question of the substitution of H22 in carbon compounds in the body is consider...

Dawn, W.Fri, H., 1975: A preliminary study of insect abundance on West Island, Aldabra Atoll, Indian Ocean. 1Heath and Rothamsted light traps and a Johnson-Taylor suction trap were used to sample flying insects on Aldabra Atoll.2The present study extended over two wet seasons. The pattern of relative monthly insect activity resembled the rainfall patter...