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EpIC: a rational pipeline for epitope immunogenicity characterization


, : EpIC: a rational pipeline for epitope immunogenicity characterization. Bioinformatics 31(14): 2388-2390

Efforts to develop peptide-based vaccines, in particular those requiring site-specific targeting of self-proteins, rely on the ability to optimize the immunogenicity of the peptide epitopes. Currently, screening of candidate vaccines is typically performed through low-throughput, high-cost animal trials. To improve on this we present the program EpIC, which enables high-throughput prediction of peptide immunogenicity based on the endogenous occurrence of B-cell epitopes within native protein sequences. This information informs rational selection of immunogenicity-optimized epitopes for peptide vaccines. EpIC is available as a web server at http://saphire.usask.ca/saphire/epic.

US$19.90

PMID: 25750418

DOI: 10.1093/bioinformatics/btv136


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