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Epidemiological investigation of an outbreak of hepatitis A in rural China

, : Epidemiological investigation of an outbreak of hepatitis A in rural China. International Journal of Infectious Diseases 33(): 191-195

This investigation was a response to an outbreak of hepatitis A in rural China in 2013. The objectives were to identify the pattern of transmission and the risk factors. A probable case was defined as an individual in/nearby the village of the outbreak with jaundice and/or an elevation of serum alanine aminotransferase (at or above 80 IU/l) plus at least three of the following symptoms: fever (axillary temperature ≥37 °C), headache, nausea, vomiting, anorexia, or abdominal pain in the upper right quadrant, during the outbreak period (from June 1 to August 11, 2013). Using a case-control study design, we compared exposures to suspected food items, water, and close contact with a patient or case with asymptomatic infection between 22 cases and 32 controls. We identified 22 cases, including 15 symptomatic cases and seven with asymptomatic infections. All cases were aged <15 years. Household clustering was apparent (Chi-square=4.69, p<0.05). Contact with symptomatic cases or cases with an asymptomatic infection was a major risk factor (59.09% in cases and 25.00% in the controls: odds ratio (OR) 4.33, 95% confidence interval (CI) 1.17-16.68). A good hand-washing habit (at least once per day) was found in 45.45% of cases vs. 78.13% of controls (OR 0.23, 95% CI 0.06-0.88). The dose-response analysis showed that the daily frequency of hand-washing was inversely associated with infection (trend Chi-square=5.35, p=0.021). Person-to-person transmission was deduced from the epidemic curves and the transmission chain of symptomatic cases. The pattern of transmission in this outbreak was person-to-person, and the transmission route was indicated to be fecal-oral. In addition to close contact, insufficient hand-washing was a risk factor. Strengthening the management of the rural environmental sanitation services and enhancing awareness in the household are key to preventing outbreaks of hepatitis A in the future.


PMID: 25677727

DOI: 10.1016/j.ijid.2015.02.006

Other references

Platen, J., 1939: Acute Miliary Tuberculosis in a Roe Deer. A case of generalized TB. with secondary acute miliary lesions in the lungs is described in a roe deer. A g. pig injected with material from the lesions showed generalized TB. when killed 25 days later, and growth of the organism on Petragnani&apo...

Thabe, H., 1983: Classification of hip joint involvement in rheumatoid polyarthritis. The involvement of hip joint in rheumatoid arthritis is regarded. According to the onset, clinical picture, progress and macroscopic shape of the synovial membrane a classification of rheumatoid attack is tried.

Goldenberg, S.D.; French, G.L., 2011: Diagnostic testing for Clostridium difficile: a comprehensive survey of laboratories in England. Recent studies have shown poor performance of commonly used toxin enzyme immunoassays (EIAs) for laboratory testing for Clostridium difficile infection (CDI). In 2009-2010, the UK Health Protection Agency and the European Society of Clinical Micro...

Lopashov, G.V.; Selter, H.; Montenarh, M.; Knöchel, W.; Grunz, H.; Tiedemann, H.; Tiedemann, H., 1992: Neural inducing factors in neuroblastoma and retinoblastoma cell lines. Extraction with acid ethanol. Die Naturwissenschaften 79(8): 365-367

Han, T.Ryoon.; Kim, D-Youl.; Lim, S.Jin.; Lee, K.Jin., 2007: The control of parameters within the therapeutic range in neuromuscular electrical stimulation. The purpose of this article was to investigate the pattern of differences among three parameters according to the increased level of the muscle force obtained in response to neuromuscular electrical stimulation (NMES). Ten healthy subjects were en...

Mavzyutova I.P.; Gareishina A.S.; Matyshevskaya M.S.; Akhmetshina S.M.; Giniyatullin R.S., 1987: Biodestruction of exopolysaccharides by microorganisms from pumped in or stratal waters. Exopolysaccharides EPSM and EPSk1 synthesized by microorganisms of the genera Acetobacter, Cryptococcus are stable to the effect of the microbic community being in fresh water which is a favourable medium for its development. Exopolysaccharides EP...

Giese, A.C., 1949: A cytotoxin from Blepharisma. A brei of fragmented B. undulans contains some substance which is quite toxic to Paramecium spp. and a variety of other protozoans and to sea urchin larvae, but it is not toxic to Blepharisma itself. Paramecia suspended in a dense culture of Bleph...

Anonymous, 1995: Biosynthesis and Catabolism of Insect Hormones and Pheromones. Proceedings of a conference of the American Chemical Society. San Diego, California, 13-14 March 1994. Insect Biochemistry and Molecular Biology 25(6): 661-757

Lenk R.; Greppin H.; Chamont S., 1985: A study of the molecular dynamics in the leaves and the roots of spinach spinacia oleracea cultivar nobel by the pulse nmr. The molecular dynamics in the leaves and the roots of Spinach (Spinacia oleracea, var. Nobel) was studied by the pulsed Nuclear Magnetic Resonance (NMR). In order to characterize the state of the plant, a new parameter r, is introduced, which defi...

Bannikov Aleksandr Fedorovich, 1986: The first find of fossil painted wrasses (Teleostei) in the Sarmatian of Moldavia. Paleontologicheskiy Zhurnal 1986(1): 78-83