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Ethanol self-administration in mice under a second-order schedule


, : Ethanol self-administration in mice under a second-order schedule. Alcohol 49(6): 561-570

Long Fixed-Interval (FI) schedules, particularly second-order schedules, can engender substantial responding before drug or ethanol delivery that is uninfluenced by the direct effects of the drug or ethanol. Thus, these schedules can be used to study the effects of medications upon drug- or ethanol-seeking, uninfluenced by the direct effects of the self-administered drug or ethanol. Long FI second-order schedules are frequently used in primates and occasionally in rats. Under second-order schedules, completion of one response requirement, e.g., a Fixed Ratio 10 (FR10:S), produces a brief stimulus presentation, e.g., a 1-s 80-dB 4-kHZ tone, and this FR10:S serves as the response unit under another schedule, e.g., an FI 1800-s. Thus, the first FR10 completed after 1800 s would result in delivery both of the tone and of reinforcement, e.g., 10 × 0.01 mL 16% (w/v) ethanol. To examine if such schedules could be effectively used in mice, which have advantages in neurobiological and genetic studies, we trained eight C57BL/6J mice to respond under the schedule just described. This schedule maintained substantial responding. The temporal pattern of behavior was typical of an FI schedule with responding accelerating across the interval. We also examined the effects of acute and chronic administration of fluvoxamine on this responding, and these were modest. Finally, we examined responding when alcohol and/or tone deliveries were withheld, and found that extinction occurred most rapidly when both were withheld. This work demonstrates that long FI schedules of ethanol delivery may be useful in studying ethanol seeking in mice.

US$19.90

PMID: 26254963

DOI: 10.1016/j.alcohol.2015.06.001


Other references

Denisenko, A.D.; Vinogradov, A.G.; Pivovarova, I.I.; Kuznetsov, A.S.; Klimov, A.N., 1993: The effect of blocking the reticuloendothelial system on the metabolism of low density lipoproteins in rabbits. Intravenous ethyl oleate-induced blockade of the reticulo-endothelial apparatus (REA) in rabbits was found to reduce the elimination rate of both native and 125I-modified (acetylated) low lipoproteins. Lower lipoprotein catabolism is likely to res...

Cumlivski, B.; Hanslik, K.; Polcat, F., 1996: Ecological aspects in practice of keeping three particular breeds of sheep. Applied Animal Behaviour Science 49(1): 100

Kwiecień, A.; Krzek, J.; Zylewski, M., 2008: Stability of chosen beta-adrenolytic drugs of different polarity in basic environment. The stability of atenolol, acebutolol, and propranolol was investigated in sodium hydroxide solutions at concentrations of 0.1, 0.3, 0.5, and 1 M at 3 temperatures ranging from 37 to 95 degrees C. The degradation processes that occurred in drugs...

Alber, M., 2008: Normal tissue dose-effect models in biological dose optimisation. Sophisticated radiotherapy techniques like intensity modulated radiotherapy with photons and protons rely on numerical dose optimisation. The evaluation of normal tissue dose distributions that deviate significantly from the common clinical routin...

Schuricht, R.S.honberg, G.F.edler, W., 1983: Effect of mechanical tillage and chemical weed control on apple trees and soil properties. Archiv fur Naturschutz und Landschaftsforschung1(4): 199-213

Falk, S.; Krol, M.; Maxwell, D.P.; Rezansoff, D.A.; Gray, G.R.; Huner, N.P.A., 1994: Changes in in vivo fluorescence quenching in rye and barley as a function of reduced PSII light harvesting antenna size. The relationship between the size of the light harvesting antenna to photosystem II (LHCII) and quenching of non-photochemical and dark level fluorescence was studied in wild-type rye (Secale cereale L. cv. Musketeer) and barley (Hordeum vulgare L...

Festuccia, C.; Gravina, G.Luca.; Muzi, P.; Millimaggi, D.; Dolo, V.; Vicentini, C.; Ficorella, C.; Ricevuto, E.; Bologna, M., 2008: Her2 crosstalks with TrkA in a subset of prostate cancer cells: rationale for a guided dual treatment. To date, no effective therapeutic treatment prevents prostate cancer (PCa) progression to more advanced and invasive disease forms. It has been demonstrated that the simultaneous high expression of p185(HER2) and TrkA might confer a proliferative...

Mims, J.L.; Treff, G.; Wood, R.C., 1986: Variability of strabismus surgery for acquired esotropia. We developed a mathematical model to predict the probable success rate of the first surgery to correct acquired esotropia with normal accommodative convergence-accommodation ratio in children. A computer-averaged dose-response curve of the effect...

Laskow, M.; Newman, L., 2009: Trustees view TCAB from a business perspective. Interview by Laurie Lewis. American Journal of Nursing 109(11 Suppl): 54-54

Butterman, Steve, 1997: The young and the rotless. The writer ruminates on the implications of a tomato that does not rot. Humor.