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Ethical and regulatory considerations in the design of traumatic brain injury clinical studies

, : Ethical and regulatory considerations in the design of traumatic brain injury clinical studies. Handbook of Clinical Neurology 128: 743-759

Research is essential for improving outcomes after traumatic brain injury (TBI). However, the ubiquity, variability, and nature of TBI create many ethical issues and accompanying regulations for research. To capture the complexity and importance of designing and conducting TBI research within the framework of key ethical principles, a few highly relevant topics are highlighted. The selected topics are: (1) research conducted in emergency settings; (2) maintaining equipoise in TBI clinical trials; (3) TBI research on vulnerable populations; and (4) ethical considerations for sharing data. The topics aim to demonstrate the dynamic and multifaceted challenges of TBI research, and also to stress the value of addressing these challenges with the key ethical principles of respect, beneficence, and justice. Much has been accomplished to ensure that TBI research meets the highest ethical standards and has fair and enforceable regulations, but important challenges remain and continued efforts are needed by all members of the TBI research community.


PMID: 25701918

DOI: 10.1016/B978-0-444-63521-1.00046-7

Other references

Thiaucourt, P., 1973: Lepidoptera Notodonitidae from Gudaeloupe. Bulletin 78 (5 6) 213-215

Dubost, N.J.; Shewfelt, R.L.; Eitenmiller, R.R., 2003: Consumer acceptability, sensory and instrumental analysis of peanut soy spreads. The textural properties of commercial peanut butter, commercial soyabean nut spread and 3 formulated peanut soyabean spreads with 8, 14, and 20% isolated soya protein were characterized using the Texture Analyser TA.TX2Reg. Significant differences...

Tseng B.Y.; Ahlem C.N., 1984: Mouse primase initiation sites in the origin region of sv 40. The sites of initiation of DNA synthesis by purified mouse DNA primase in the origin-of-replication region of SV40 were examined. Using as template the separated strands of a cloned fragment of SV40 .simeq. 300 base pairs (bp) long that includes t...

Pericart, J., 1986: Comments on the proposed designation of a type species for Berytus Fabricius, 1803 (Insecta, Heteroptera) Z.N.(S.) 2464 (1). Bulletin of Zoological Nomenclature, 432: 119

Arnon, S.; Tamary, H.; Dgany, O.; Litmanovitz, I.; Regev, R.; Bauer, S.; Dolfin, T.; Yacobovich, J.; Wolach, B.; Jaber, L., 2004: Hydrops fetalis associated with homozygosity for hemoglobin Taybe (alpha 38/39 THR deletion) in newborn triplets. Hemoglobin Taybe is an unstable alpha-chain hemoglobin variant caused by a deletion of a threonine residue at codon 38 or 39 of the alpha-1 globin chain. We describe preterm infant triplets born with hydrops fetalis and anemia who were found by DN...

Donisthorpe, H., 1925: Insects in the Nest of the Grey Squirrel. The insects recorded in nests of the grey squirrel include Ceratophyllus wickhami, Baker, recorded for the first time from Britain. In North America this flea is a well-known parasite of this host.

Shuhaiber, H.; Chugh, T.; Burns, G., 1989: In vitro adherence of bacteria to sutures in cardiac surgery. The adherence of bacteria to sutures used in cardiac surgery was studied by in vitro quantitative determination with [3H]-leucine-labeled Staphylococcus epidermidis, Staphylococcus aureus and Streptococcus sanguis. The adherence per unit area for...

Galasko, D., 2003: Insulin and Alzheimer's disease: an amyloid connection. Neurology 60(12): 1886-1887

Altrichter, K., 1975: Brutbestands aufnahme von Graureiher, Haubentaucher, Hockerschwan und Lachmowe 1975 in Schwaben. Bericht naturw Ver Schwaben, 791-2: 9

Park, T.; Davis, M.B.ggs, 1945: Further analysis of fecundity in the flour beetles, Tribolium confusum Duval and Tribolium castaneum Herbst. T. castaneum has a higher fecundity rate by about 6% than T. confusum. It is possible through selection to develop a stock of T. castaneum with a 15% greater fecundity rate than the parental generation, but not possible to do this for T. confusum....