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Ethics of Cancer Gene Transfer Clinical Research


, : Ethics of Cancer Gene Transfer Clinical Research. Methods in Molecular Biology 1317: 263-285

Translation of cancer gene transfer confronts many familiar-and some distinctive-ethical challenges. In what follows, I survey three major ethical dimensions of cancer gene transfer development. Subheading 1 centers on the ethics of planning, designing, and reporting animal studies. Subheading 2 describes basic elements of human subjects protection as pertaining to cancer gene transfer. In Subheading 3, I describe how cancer gene transfer researchers have obligations to downstream consumers of the evidence they produce.

US$19.90

PMID: 26072412

DOI: 10.1007/978-1-4939-2727-2_15


Other references

Biswas, A.Kumar.; Mitchell, D.L.; Johnson, D.G., 2014: E2F1 responds to ultraviolet radiation by directly stimulating DNA repair and suppressing carcinogenesis. In response to DNA damage, the E2F1 transcription factor is phosphorylated at serine 31 (serine 29 in mouse) by the ATM or ATR kinases, which promotes E2F1 protein stabilization. Phosphorylation of E2F1 also leads to the recruitment of E2F1 to sit...

Sasaki, H.; Kawano, R.; Osaki, T.; Kamiya, K.; Takeuchi, S., 2012: Single-vesicle estimation of ATP-binding cassette transporters in microfluidic channels. We have developed a method to analyze the substrate transport of ATP-binding cassette (ABC) transporters, which are associated with drug resistance in tumor cells. Our microfluidic method is well suited to the single-vesicle estimation of substrat...

Shaw, F-Zen.; Lee, S-Ying.; Chiu, T.H., 2006: Modulation of somatosensory evoked potentials during wake-sleep states and spike-wave discharges in the rat. Study Objective: To clarify the cortical evoked responses in the primary somatosensory cortex of the rat under states of waking, slow-wave sleep (SWS), paradoxical sleep (PS), and spike-wave discharges (SWDs), which are associated with absence sei...

Wilding; Hirst; Connor, 2000: Development of a new engineering-based capsule for human drug absorption studies. Over recent years, there has been a significant growth in the number of new drugs entering development with challenging pharmaceutical (e.g. solubility) and biopharmaceutical (e.g. permeability) properties. As a consequence, there is an increasing...

Wang, Q-fu.; Li, W.; Yang, H.; Liu, Y-li.; Cao, H-hua.; Dornmayr-Pfaffenhuemer, M.; Stan-Lotter, H.; Guo, G-qin., 2007: Halococcus qingdaonensis sp. nov., a halophilic archaeon isolated from a crude sea-salt sample. A Gram-negative, extremely halophilic, coccoid archaeal strain, CM5(T), was isolated from a crude sea-salt sample collected near Oingdao, China. The organism grew optimally at 35-40 degrees C and pH 6.0 in the presence of 20 % (w/v) NaCl. Its col...

Anonymous, 2003: ACOG committee opinion number 287, October 2003: newborn screening. Newborn screening programs have enormous public health benefits and have been effective in identifying newborns who can benefit from early treatment. Because of advances in genetics and technology, newborn screening programs are capable of testing...

Meyer-Bahlburg, H.F.L.; Dolezal, C.; Zucker, K.J.; Kessler, S.J.; Schober, J.M.; New, M.I., 2007: The Recalled Childhood Gender Questionnaire-Revised: a psychometric analysis in a sample of women with congenital adrenal hyperplasia. We administered the 18-item Recalled Childhood Gender Questionnaire-Revised (RCGQ-R), female version, to 147 adult women with congenital adrenal hyperplasia (CAH) representing three different degrees of prenatal androgenization due to 21-hydroxyla...

Chandler, W.F.; Kindt, G.W., 1976: Monitoring and control of intracranial pressure in non-traumatic encephalopathies. Fifteen patients with non-traumatic encephalopathies underwent continuous monitoring of intracranial pressure. These included 11 children with Reye's syndrome, two with viral encephalitis, one with mushroom poisoning, and one with hypoxia fro...

Barbieri M.; Fornaseri M.; Penta A., 1968: Rubidium and potassium relationship in some volcanoes of central Italy. K/Rb ratios in extrusive and pyroclastic rocks, Rb enrichment in pyroclastics, role of magmatic crystallization-weathering and other secondary alteration processes, importance of host mineral structural type.

Rovelli F.; Tognoni G., 1984: Protocol of the italian study on strepto kinase in myo cardial infarction. Haemostasis 14(1): 7