geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Exercise training is an effective alternative to estrogen supplementation for improving glucose homeostasis in ovariectomized rats


, : Exercise training is an effective alternative to estrogen supplementation for improving glucose homeostasis in ovariectomized rats. Physiological Reports 3(11): -

The irreversible loss of estrogen (specifically 17-β-estradiol; E2) compromises whole-body glucose tolerance in women. Hormone replacement therapy (HRT) is frequently prescribed to treat estrogen deficiency, but has several deleterious side effects. Exercise has been proposed as an HRT substitute, however, their relative abilities to treat glucose intolerance are unknown. Thirty ovariectomized (OVX) and 20 SHAM (control) rats underwent glucose tolerance tests (GTT) 10 weeks post surgery. Area under the curve (AUC) for OVX rats was 60% greater than SHAM controls (P = 0.0005). Rats were then randomly assigned to the following treatment groups: SHAM sedentary (sed) or exercise (ex; 60 min, 5×/weeks), OVX sed, ex, or E2 (28 μg/kg bw/day) for 4 weeks. OVX ex rats experienced a ~45% improvement in AUC relative to OVX sed rats, whereas OVX E2 underwent a partial reduction (17%; P = 0.08). Maximal insulin-stimulated glucose uptake in soleus and EDL was not impaired in OVX rats, or augmented with exercise or E2. Akt phosphorylation did not differ in soleus, EDL, or liver of any group. However, OVX ex and OVX E2 experienced greater increases in p-Akt Ser473 in VAT and SQ tissues compared with SHAM and OVX sed groups. Mitochondrial markers CS, COXIV, and core1 were increased in soleus posttraining in OVX ex rats. The content of COXIV was reduced by 52% and 61% in SQ of OVX sed and E2 rats, compared to SHAM controls, but fully restored in OVX ex rats. In summary, exercise restores glucose tolerance in OVX rats more effectively than E2. This is not reflected by alterations in muscle maximal insulin response, but increased insulin signaling in adipose depots may underlie whole-body improvements.

US$19.90

PMID: 26603453

DOI: 10.14814/phy2.12617


Other references

Cronberg, N.; Rydin, H., 2005: Torvmossa - ett nygammalt svenskt namn for Sphagnum. A case is made for changing the unfortunate Swedish name for the genus Sphagnum from "vitmossor" (white mosses) to "torvmossor" (peat mosses).

Kerr, D.L.; McLaren, D.G.; Mathy, R.M.; Nitschke, J.B., 2012: Controllability modulates the anticipatory response in the human ventromedial prefrontal cortex. Research has consistently shown that control is critical to psychological functioning, with perceived lack of control considered to play a crucial role in the manifestation of symptoms in psychiatric disorders. In a model of behavioral control bas...

Ehrenberg, S.N.; Aqrawi, A.A.M.; Nadeau, P.H., 2008: An overview of reservoir quality in producing Cretaceous strata of the Middle East. A compilation of average porosity and permeability data for Cretaceous petroleum reservoirs of the Middle East reveals important differences between the two main tectonic provinces. The Arabian Platform is characterized by inverse correlation of a...

Beck, W.A.; Schocken, K.; Donnelly, S.M.ry Winifred, 1938: Cell enlargement in the hypocotyl of Helianthus annuus. The cell enlargement as it normally occurs in the epidermal and cortical cells in the hypocotyl was detd. The data are to be employed in future work. The areas of the cells within 2 regions (0-5 and 45-50 mm. below the plumule) were compared. For...

Lutz, S., 1992: Multi-unit providers psychiatric hospitals survey 1992. Psych providers being buffeted by payer pressures, stricter scrutiny. Modern Healthcare 22(20): 72, 74, 76-72, 74, 76

Hasin, D.S.; Grant, B.F., 1987: Assessment of specific drug disorders in a sample of substance abuse patients: a comparison of the DIS and the SADS-L procedures. Both the DIS and the SADS-L interviews offer researchers a procedure for assessing the presence of drug disorders categorized by drug class, as defined by psychiatric nomenclatures. In this study, the performance of the drug section of each interv...

Rock B.N., 1983: Mapping of deciduous forest cover using airborne thermatic mapper simulator data. American Journal of Botany 70(5 PART 2): 54

Vieira, C.; Piganeau, G.; Biémont, C., 2000: High copy numbers of multiple transposable element families in an Australian population of Drosophila simulans. Sudden mobilization of transposable elements in Drosophila is a well-reported phenomenon but one that usually affects no more than a few elements (one to four). We report here the existence of a D. simulans natural population (Canberra) from Austr...

Prokofieva-Belgovskaya, AA., 1940: Heterocyelicity of the system of cell nucleus. C R Acad Sci Moscow N S: 53: 741-744

Lin, C.F.ng; Lo, S.S.in; Lin, H.Y.h; Lee, Y., 1998: Stabilization of cadmium contaminated soils using synthesized zeolite. This research investigates the effect of synthesized zeolite on stabilizing Cd-contaminated soil, using 0.01 M CaCl2 leaching solution in batch and column experiments. The zeolite was synthesized from fly ash obtained from a Coal-Fired Power Plant...