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Flexible synthesis of cationic peptide-porphyrin derivatives for light-triggered drug delivery and photodynamic therapy


, : Flexible synthesis of cationic peptide-porphyrin derivatives for light-triggered drug delivery and photodynamic therapy. Organic & Biomolecular Chemistry 14(48): 11488-11501

NlmCategory="UNASSIGNED">Efficient syntheses of cell-penetrating peptide-porphyrin conjugates are described using a variety of bioconjugation chemistries. This provides a flexible means to convert essentially hydrophobic tetrapyrolle photosensitisers into amphiphilic derivatives which are well-suited for use in light-triggered drug delivery by photochemical internalisation (PCI) and targeted photodynamic therapy (PDT).

US$19.90

PMID: 27886311

DOI: 10.1039/c6ob02135b


Other references

Fukami, T.; Nakajima, M.; Higashi, E.; Yamanaka, H.; McLeod, H.L.; Yokoi, T., 2005: A novel CYP2A6*20 allele found in African-American population produces a truncated protein lacking enzymatic activity. Human CYP2A6 is a cytochrome P450 (CYP) isoform responsible for the metabolism of nicotine, coumarin, tegafur, and valproic acid, and metabolic activation of nitrosamines. Genetic polymorphisms of the CYP2A6 gene are a major causal factor of the l...

El-Seweidy, M.M.; Sadik, N.Abdel.Hamid.; Malek, M.M.; Amin, R.S., 2014: Chronic effects of clozapine administration on insulin resistance in rats: evidence for adverse metabolic effects. Chronic treatment with the atypical antipsychotics clozapine has been associated with an increased risk for deterioration of glucose homeostasis, leading to hyperglycemia and insulin resistance diabetes. The present study mainly aimed to investiga...

Shanes, A.M.; Brown, D.E.S., 1942: The effect of metabolic inhibitors on the resting potential of frog nerve. The action of inhibitors, chiefly Na iodoacetate, NaF, and phylorizin, and of metabolites like pyruvate and lactate, were studied. As compared with paired normal controls, nerves soaked in the poisons for 16 hrs. at low temp. were left with 50% of...

Loebsack, A.; Greene, K.; Wyatt, S.; Culberson, C.; Austin, C.; Beiler, R.; Roland, W.; Eiselt, P.; Rowley, J.; Burg, K.; Mooney, D.; Holder, W.; Halberstadt, C., 2001: In vivo characterization of a porous hydrogel material for use as a tissue bulking agent. Tissue engineered biomaterial constructs are needed for plastic and reconstructive applications. To successfully form a space-filling tissue, the construct should induce a minimal inflammatory response, create minimal or no fibrotic capsule, and e...

Gao, J., 1998: Metastasis of cancer: model establishment and relevant standard. Zhonghua Yi Xue Za Zhi 77(9): 647-648

Lee, R.Y.N.; Lobel, L.; Hengartner, M., 1997: Mutations in the a1 subunit of an L-type voltage-activated Ca2+ channel cause myotonia in Caenorhabditis elegans. The EMBO Journal 16: 66-76

Kayser, J.; Lavollay, J., 1978: Growth and longevity of Wistar rats on a diet with protein content rapidly decreased as a function of age. Growth and longevity of rats were the same on a diet of 21% casein from weaning to death or with the protein content reduced progressively to age 200 days and thereafter 7%. When the casein content was reduced rapidly to impair growth after 75 day...

Xia, C-hong.; Liu, H.; Wang, M.; Cheung, D.; Park, A.; Yang, Y.; Du, X.; Chang, B.; Beutler, B.; Gong, X., 2007: Characterization of mouse mutants with abnormal RPE cells. Advances in Experimental Medicine and Biology 572: 95-100

Gallo, P.M.; Gallucci, S., 2013: The dendritic cell response to classic, emerging, and homeostatic danger signals. Implications for autoimmunity. Dendritic cells (DCs) initiate and control immune responses, participate in the maintenance of immunological tolerance and are pivotal players in the pathogenesis of autoimmunity. In patients with autoimmune disease and in experimental animal mode...

Gunzel, A.; Mattos, R.; Tekin, N., 1982: Semen quality of rams of the German Mutton Merion breed during one year (from December 1979 to December 1980) with special respect to the acrosome morphology. Berliner und Munchener tierarztliche Wochenschrift 95(3): 49-55