+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Forsythia suspensa fruit extracts and the constituent matairesinol confer anti-allergic effects in an allergic dermatitis mouse model

, : Forsythia suspensa fruit extracts and the constituent matairesinol confer anti-allergic effects in an allergic dermatitis mouse model. Journal of Ethnopharmacology 187(): 49-56

Forsythia suspensa is used in traditional medicine to treat inflammation. To clarify the anti-inflammatory and anti-allergic effects of F. suspensa fruits, we determined the therapeutic effects of crude extract, fractions, and a constituent from F. suspensa fruits on a murine atopic dermatitis (AD) model. We investigated the inhibitory effects of F. suspensa extract (FSE), extract fractions, and the constituent matairesinol on histamine release from MC/9 mast cells activated by compound 48/80 and the development of AD-like skin lesions and symptoms in NC/Nga mice exposed to Dermatophagoides farinae (mite) extract. High performance liquid chromatography (HPLC) analysis of FSE and its fractions were evaluated using matairesinol standard. FSE, FSE methylene chloride fraction (FSE-MC), and FSE water fraction (FSE-water) inhibited compound 48/80-induced histamine release from MC/9 mast cells. Topical application of FSE or FSE-MC to NC/Nga mice exposed to Dermatophagoides farinae suppressed the development of AD-like skin lesions. Quantitative HPLC analysis of FSE and FSE-MC identified the presence of matairesinol. Topical application of matairesinol to NC/Nga mice effectively reduced AD symptoms, inhibited inflammatory cell infiltration, and lowered immunoglobulin E levels in serum. Further study demonstrated that DfE-induced changes in IL-4 and IFN-γ mRNA expression in the ears of NC/Nga mice were reversed by matairesinol application. These results indicate that the F. suspensa and its constituent matairesinol might be a therapeutic candidate for treating allergic inflammatory disorders such as AD.


PMID: 27085937

DOI: 10.1016/j.jep.2016.04.015

Other references

Terris, M., 1969: Letters to the editor: alcoholism. American Journal of Public Health and the Nation's Health 59(11): 1980-1982

Kirk, K.; Ashworth, K.J.; Elford, B.C.; Pinches, R.A.; Ellory, J.C., 1991: Characteristics of 86Rb+ transport in human erythrocytes infected with Plasmodium falciparum. Human red cells infected in vitro with Plasmodium falciparum showed a significant increase in the rate of both ouabain-sensitive and ouabain-insensitive 86Rb+ influx. The increase in ouabain-insensitive 86Rb+ influx was due, in part, to increased...

Buchberger, R., 1970: Could combined therapy improve the late results in bronchial carcinoma?. Medizinische Klinik 65(48): 2107-2113

Xafis, V., 2016: Why respecting all human beings' privacy matters. Journal of Paediatrics and Child Health 52(3): 256-257

Stocchetti, N.; Maas, A.I.R.; Chieregato, A.; van der Plas, A.A., 2005: Hyperventilation in head injury: a review. The aim of this review was to consider the effects of induced hypocapnia both on systemic physiology and on the physiology of the intracranial system. Hyperventilation lowers intracranial pressure (ICP) by the induction of cerebral vasoconstrictio...

Palmer D.; Jones C., 1985: Production of monoclonal antibody of predefined specificity in the chinese hamster cricetulus griseus. Federation Proceedings 44(4): 1329

Banihashemi, M., 2016: Using Quasi-Horizontal Alignment in the absence of the actual alignment. Horizontal alignment is a major roadway characteristic used in safety and operational evaluations of many facility types. The Highway Safety Manual (HSM) uses this characteristic in crash prediction models for rural two-lane highways, freeway segm...

Royston, D., 1997: A case for aprotinin in patients having deep hypothermic circulatory arrest. Journal of Cardiac Surgery 12(2 Suppl): 214-20; Discussion 220-1

Matheis, K., 1974: Thoughts on the new health insurance. Zahnarzteblatt Baden-Wurttemberg 2(9): 197-197

Green, R., 1978: Math called key to Indian self-determination. Science 201(4354): 433-433