+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Functional interplay between PPM1G and the transcription elongation machinery

, : Functional interplay between PPM1G and the transcription elongation machinery. Rna & Disease 3(1): -

NlmCategory="UNASSIGNED">Transcription elongation is a critical regulatory step in the gene expression cycle. One key regulator of the switch between transcription initiation and elongation is the P-TEFb kinase, which phosphorylates RNA polymerase II (Pol II) and several negative elongation factors to relieve the elongation block at paused promoters to facilitate productive elongation. Here, we highlight recent findings signifying the role of the PPM1G/PP2Cγ phosphatase in activating and maintaining the active transcription elongation state by regulating the availability of P-TEFb and blocking its assembly into the catalytic inactive 7SK small nuclear ribonucleoprotein (snRNP) complex.


PMID: 27088130

Other references

Nuccitelli R., 1984: The involvement of transcellular ion currents and electric fields in pattern formation. Malacinski, G M And S V Bryant (Ed ) Pattern Formation: A Primer in Developmental Biology Xxvii+626p Macmillan Publishing Co: New York, N Y , Usa; Collier Macmillan Publishers: London, England Illus 23-46

Gupta, R.B.; Rao, G.R., 1973: Effect of elimination of different causes of death on expectation of life-Bombay, 1960-61. Indian Journal of Medical Research 61(6): 950-961

Lang, N.; Yuan, H-Shu., 2015: Computed Tomography and Magnetic Resonance Manifestations of Spinal Pigmented Villonodular Synovitis. To study computed tomography (CT) and magnetic resonance imaging (MRI) findings of spinal pigmented villonodular synovitis (PVNS), with the aim of improving diagnostic accuracy. Findings from CT (n = 7) and MRI (n = 5) of 7 cases of spinal PVNS, d...

Gall, H.; Zachow, B., 1992: Pendulum gadget MIDAS P 88. Assessment of the bruising behaviour of potato tubers. Bruising induced by an electrically operated pendulum was investigated in laboratory studies in 1991. Differences between cultivars in their susceptibility to bruising were quantified using 4 parameters: pendulum index (recoil of the second stroke...

Healey, A.; Mitchell, R.; Upcroft, J.A.; Boreham, P.F.; Upcroft, P., 1990: Complete nucleotide sequence of the ribosomal RNA tandem repeat unit from Giardia intestinalis. The complete nucleotide sequence of the 5566 bp rRNA tandem repeat unit from the genome of G. intestinalis [G. lamblia] is presented. The sequence starts at a KpnI site in the 16S rRNA gene used for cloning and previous mapping studies. There are...

Rusconi, L.; Maccaferri, A., 1969: Indications, technic and long term results of apicoectomy. Archivio Stomatologico 10(2): 73-92

Oelze J., 1991: Diazotrophic mixed culture of azotobacter vinelandii and rhodobacter capsulatus. The question, whether Azotobacter vinelandii can provide fixed N for the growth of other organisms, was studied with mixed cultures of A. vinelandii an Rhodobacter capsulatus, grown with aeration in the light. N2-fixation by R. capsulatus was prev...

Anonymous, 1971: Future composition of a hospital. Discussion of the lecture of the Director of Medical Services (Ugeskr. Laeger 1971:133,2051-2058). Ugeskrift for Laeger 133(43): 2153-2164

Palacios, R.; Orensanz, J.M.; Armstrong, D.A., 1994: Seasonal and life-long variation of Sr/Ca ratio in shells of Mya arenaria from Grays Harbor An ancillary criterion in demographic studies. Mya arenaria was introduced to Grays Harbor (Washington) during the 1880s. Maximum size of members of the extant population is much smaller than that of clams dead in situ n preceding decades and nowadays found forming extensive ' death assem...

Yoshimura, Y.; Abe, T.; Atsuka, K., 1981: Field test of tractor wheel operation performance and ground-to-tyre coefficients. A rear-wheel-drive tractor was fitted with telemetry instruments to measure drive wheel thrust and slip, the instrumented tractor pulling a braking vehicle when operating. Four different FM signals generated by the instruments were sent out from t...